or
Sign in to turn on 1-Click ordering.
 
 
Express Checkout with PayPhrase
What's this? | Create PayPhrase
Sorry!
More Buying Choices
45 used & new from $69.00

Have one to sell? Sell yours here
 
   
Classics in Total Synthesis: Targets, Strategies, Methods
 
 
Tell the Publisher!
I’d like to read this book on Kindle

Don’t have a Kindle? Get your Kindle here.
 
  

Classics in Total Synthesis: Targets, Strategies, Methods (Paperback)

~ (Author), E. J. Sorensen (Author) "The Strychnos species, indigenous to the rain forests of the Southeast Asian archipelagos and the Coromandel Coast of India, harbor the notorious poison strychnine (1)..." (more)
Key Phrases: acetoxythioacetal function, hydroxy epoxide cyclization, conventional functional group manipulations, New York, Tetrahedron Lett, Academic Press (more...)
5.0 out of 5 stars  See all reviews (8 customer reviews)

List Price: $110.00
Price: $93.50 & this item ships for FREE with Super Saver Shipping. Details
You Save: $16.50 (15%)
o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o
Usually ships within 7 to 11 days.
Ships from and sold by Amazon.com. Gift-wrap available.

25 new from $71.00 20 used from $69.00

Formats

Amazon Price New from Used from
  Hardcover -- $182.03 $80.00
  Paperback $93.50 $71.00 $69.00

Frequently Bought Together

Classics in Total Synthesis: Targets, Strategies, Methods + Classics in Total Synthesis II: More Targets, Strategies, Methods (Vol. 2) + Strategic Applications of Named Reactions in Organic Synthesis
Price For All Three: $240.48

Some of these items ship sooner than the others. Show details

  • This item: Classics in Total Synthesis: Targets, Strategies, Methods by K. C. Nicolaou

    Usually ships within 7 to 11 days.
    Ships from and sold by Amazon.com.
    This item ships for FREE with Super Saver Shipping. Details

  • Classics in Total Synthesis II: More Targets, Strategies, Methods (Vol. 2) by K. C. Nicolaou

    Usually ships within 7 to 11 days.
    Ships from and sold by Amazon.com.
    This item ships for FREE with Super Saver Shipping. Details

  • Strategic Applications of Named Reactions in Organic Synthesis by Laszlo Kurti

    In Stock.
    Ships from and sold by Amazon.com.
    This item ships for FREE with Super Saver Shipping. Details


Customers Who Bought This Item Also Bought

Strategic Applications of Named Reactions in Organic Synthesis

Strategic Applications of Named Reactions in Organic Synthesis

by Laszlo Kurti
5.0 out of 5 stars (15)  $77.78
The Art of Writing Reasonable Organic Reaction Mechanisms

The Art of Writing Reasonable Organic Reaction Mechanisms

by Robert B. Grossman
4.9 out of 5 stars (25)  $47.03
Advanced Organic Chemistry: Part B: Reaction and Synthesis (Advanced Organic Chemistry / Part B: Reactions and Synthesis)

Advanced Organic Chemistry: Part B: Reaction and Synthesis (Advanced Organic Chemistry / Part B: Reactions and Synthesis)

by Francis A. Carey
4.3 out of 5 stars (21)  $36.01
Modern Physical Organic Chemistry

Modern Physical Organic Chemistry

by Eric V. Anslyn; Dennis A. Dougherty
4.7 out of 5 stars (14)  $114.00
The Logic of Chemical Synthesis

The Logic of Chemical Synthesis

by E. J. Corey
4.7 out of 5 stars (7)  $70.97
Explore similar items

Editorial Reviews

Product Description

This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.

To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.

Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.

Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.


From the Publisher

This book is first to cover in detail the syntheses, reactions, and physical properties of nitrocarbons. Examples from the group of other, as yet unknown nitrocarbons are also discussed. It further includes a very complete survey of all published literature on the subject.

Product Details

  • Paperback: 821 pages
  • Publisher: Wiley-VCH (December 16, 1996)
  • Language: English
  • ISBN-10: 3527292314
  • ISBN-13: 978-3527292318
  • Product Dimensions: 9.7 x 7.5 x 1.3 inches
  • Shipping Weight: 3.5 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (8 customer reviews)
  • Amazon.com Sales Rank: #408,333 in Books (See Bestsellers in Books)

More About the Author

K. C. Nicolaou
Discover books, learn about writers, read author blogs, and more.

Visit Amazon's K. C. Nicolaou Page

Inside This Book (learn more)
First Sentence:
The Strychnos species, indigenous to the rain forests of the Southeast Asian archipelagos and the Coromandel Coast of India, harbor the notorious poison strychnine (1). Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
acetoxythioacetal function, hydroxy epoxide cyclization, conventional functional group manipulations, polyol glycoside subunit, endiandric acids, retrosynthetic cleavage, intramolecular etherification reaction, palytoxin carboxylic acid, outlined retro, conjugated triene moiety, hindered concave face, necessary deoxygenation, remote stereochemical relationships, contiguous asymmetric carbon atoms, inherent diastereofacial preference, retrosynthetic precursor, significant structural simplification, intermolecular aldol condensation, oxepane rings, preferred stereochemical course, relative stereochemical relationships, cycloaddition event, methoxycarbonyl function, projected precursor, veratryl ring
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Tetrahedron Lett, Academic Press, Pergamon Press, John Wiley, Aldrichimica Acta, The Logic of Chemical Synthesis, Prostaglandin Fea, Perkin Trans, Van Tamelen, San Diego, Meo Meo, New Jersey, Princeton University Press, American Chemical Society, Justus Liebigs Ann, Marcel Dekker, Protective Groups, Takasago Corporation, Tandem Organic Reactions, Acta Crystallogr, Interscience Publishers, Plenum Press, Royal Society of Chemistry, Tokyo Kagaku Dozin
New!
Books on Related Topics | Concordance | Text Stats
Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Search Inside This Book:




What Do Customers Ultimately Buy After Viewing This Item?


Tags Customers Associate with This Product

 (What's this?)
Click on a tag to find related items, discussions, and people.
 

Your tags: Add your first tag
 

Sell a Digital Version of This Book in the Kindle Store

If you are a publisher or author and hold the digital rights to a book, you can sell a digital version of it in our Kindle Store. Learn more

 

Customer Reviews

8 Reviews
5 star:
 (8)
4 star:    (0)
3 star:    (0)
2 star:    (0)
1 star:    (0)
 
 
 
 
 
Average Customer Review
5.0 out of 5 stars (8 customer reviews)
 
 
 
 
Share your thoughts with other customers:
Most Helpful Customer Reviews

 
7 of 7 people found the following review helpful:
5.0 out of 5 stars Classics in Total Synthesis Revisited, February 9, 2002
The more I read and study out from the book, the more I appreciate the beauty of it. Nicolaou and Sorensen's Classics in Total Synthesis is the most widely consulted title on organic synthesis. As many have commented, this book is a must for every synthetic organic chemist, organic student and researcher.

Released in 1995, despite the advances in synthetic methodology, Nicolaou has presented some of the most remarkable and ingenious total syntheses from laboratories of the world's most prominent organic chemists. Molecules adopted include strychnine, prostaglandin, progesterone, vitamin B12, erythronolide B, monensin, endiandric acids, biotin, hirsutene, capnellene, methyl homosecodaphniphyllate, calicheamicin and more.

Nicaolaou has done an incredible favor to make the strategies more understandable and accesible. For each molecule, the total synthesis begins with a thorough retrosynthetic analysis. Sometimes more than one retrosynthetic routes are introduced in order to show the possibilities of finding the most efficient synthesis.

Nicoloau then meticulously describle each step in synthesis with referral to important named reactions such as the Noyori assymmetric reduction, Luche reaction, Johnson Claisen rearrangement, Julia olefination, etc. With such didatic skill and clarity, Nicoloau has taught the gist of synthesizing complex molecules from commercially available building blocks. A great way to use the book and learn organic synthesis would be to write down every single step on a separate piece of paper and understand what each step does in the overall total synthesis. The synthesis steps and important reactions are presented in schemes with blue background sections, with emphasis on asymmetric synthesis, catalysts, stereochemistry and mechanism. Major reaction intermediates are presented at the margin.

Chemical synthesis relies heavily on chemical literature research. Nicoloau also provides numerous references in each total synthesis for further studies and consultation. Nicoloau has made organic synthesis fun and approachable. Every synthetic chemist should own a copy of Nicolaou.

Comment Comment | Permalink | Was this review helpful to you? Yes No (Report this)



 
4 of 4 people found the following review helpful:
5.0 out of 5 stars A must for synthetic organic chemists, December 12, 2000
By A Customer
This is an impressive collection of 36 syntheses. Each chapter describes a different synthesis. Included are a retrosynthetic analysis(very helpful for those learning the art of total synthesis), the total synthesis(explaining key steps along the way and why the reaction gave the products it did) and then some conclusions. The appendix in chapter 22, on Catalytic Asymetric Reactions is very useful. If you bought "The Logic of Chemical Synthesis' and were dissapointed, don't let that scare you from this book. It is well worth the price.
Comment Comment | Permalink | Was this review helpful to you? Yes No (Report this)



 
6 of 7 people found the following review helpful:
5.0 out of 5 stars This Could Be The Only Synthesis Book You Need..., August 19, 2001
A graduate student strongly recommended me to get this book and start reading. At first intimidated by the complex synthesis steps and unfamiliar reagents, the Nicolaou synthesis book is a must read for organic students and chemists. Unlike "The Logic of Chemical Synthesis" (no doubt is also well-written), Nicolaou's "Classics in Total Synthesis" is a pictorial account of some of the representative syntheses of natural products. The detailed, well-written text discusses total synthesis work of chemists such as Heathcock, Corey, Evans, and Nicolaou himself. Each synthesis is preceded with the historical background and significance. A detailed synthetic scheme is included with detailed discussion of each intemediate and inidvidual step. Reader will surely learn a great deal by working through each synthetic step with a pencil and paper. While most advanced organic texts discuss the typical traditional methods in synthetic chemistry, Nicolaou discusses practical approach to synthesizing complex stereospecific compounds. Corey's "The Logic of Chemical Syntheses" might have the similar scope in organic synthesis, yet Nicolaou will be more reader-friendly especially for beginning students in organic synthesis. Nicolaou presents not only the tactics of the subject, it also brings out the beauty of the art of total synthesis. A good read!
Comment Comment | Permalink | Was this review helpful to you? Yes No (Report this)


Share your thoughts with other customers: Create your own review
 
 
 
Most Recent Customer Reviews

5.0 out of 5 stars this is IT!
Im not big on writing reviews, and hardly ever do. I just wanted to add to the previous reviewers comments and say that this is hands down the best organic text available today. Read more
Published 15 months ago by Michael P. Cook

5.0 out of 5 stars Absolute must for organic synthetic chemists!
If you want to do (total) synthesis yourself it is an absolute must to read this book. Not the book itself, but the synthesis described are brilliant. Read more
Published on November 26, 1999

5.0 out of 5 stars Well-worth the price
It is an amazing work detailing many of the greatest accomplishments attained in organic chemistry. As a student, I recommend it highly.
Published on August 5, 1999 by buckric@charlie.cns.iit.edu

5.0 out of 5 stars Essential reading for all organic chemists.
Nicolaou has written the book that Corey's _Logic of Chemical Synthesis_ should have been. The total synthesis of over thirty natural products is described in great detail,... Read more
Published on July 28, 1996

5.0 out of 5 stars Essential reading for all organic chemists.
Nicolaou has written the book that Corey's _Logic of Chemical Synthesis_ should have been. The total synthesis of over thirty natural products is described in great detail,... Read more
Published on July 28, 1996

Only search this product's reviews



Customer Discussions

This product's forum
Discussion Replies Latest Post
No discussions yet

Ask questions, Share opinions, Gain insight
Start a new discussion
Topic:
First post:
Prompts for sign-in
 


Active discussions in related forums
Search Customer Discussions
Search all Amazon discussions
   



So You'd Like to...


Create a guide

Product Information from the Amapedia Community

Beta (What's this?)


Look for Similar Items by Category


Look for Similar Items by Subject

 

Feedback

If you need help or have a question for Customer Service, contact us.
 Would you like to update product info or give feedback on images?
Is there any other feedback you would like to provide?

Your comments can help make our site better for everyone.


Your Recent History

 (What's this?)

After viewing product detail pages or search results, look here to find an easy way to navigate back to pages you are interested in.