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Editorial Reviews
Review
"The editor has managed to recruit a team of well-recognized experts as authors for this book, thereby ensuring a high standard of reliable and objective reporting. The book is not only of interest to specialists in pharmaceutical research and development, but will certainly also be a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their application to biomolecules" (Angewandte Chemie Int. Ed.)
"The editor has managed to recruit a team of well-recognized experts as authors for this book, thereby ensuring a high standard of reliable and objective reporting. The book is not only of interest to specialists in pharmaceutical research and development, but will certainly also be a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their application to biomolecules" (Angewandte Chemie Int. Ed.)
"The book presents a good overview of state-of-the-art NMR techniques in drug discovery. [...] It is suggested reading for people involved in pharmaceutical research as well as academic researchers with an interest in drug discovery." (ChemBioChem)
"...certainly a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their applications..." (Angewandte Chemie International Edition, Vol. 42, 2003)
Product Description
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt W?h. Edited by a former coworker of W?h, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.
BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D—an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.
With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.
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Inside This Book Citations: This book cites 11 books | 8 books that cite this book Explore: Citations | Books on Related Topics | Concordance | Text Stats Key Phrases - SIPs: torsion angle dynamics algorithm, recoupling sequences, predicted dipolar couplings, perdeuterated proteins, ambiguous distance constraints (more) Key Phrases - CAPs: New York, Methods Enzymol, Chem Soc, Magn Reson, Proc Natl (more) Browse Sample Pages: Front Cover | Copyright | Table of Contents | Excerpt | Index | Back Cover | Surprise Me! |
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Inside This Book
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First Sentence:
The introduction of stable isotopes into proteins has significantly reduced the time requirements for structure elucidation of biomolecules. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
torsion angle dynamics algorithm, recoupling sequences, predicted dipolar couplings, perdeuterated proteins, ambiguous distance constraints, chemical shift list, algal hydrolyzate, paramagnetic relaxation enhancement, primary screening hits, repulsive core radii, orienting media, alignment tensor, favorable relaxation properties, using dipolar couplings, dipolar coupling data, backbone cyclization, protein ligation, dipolar coupling value, isotope filtering, split intein, bipolar couplings, residual dipolar couplings, torsion angle constraints, chemical shift mapping, ligand resonances Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Methods Enzymol, Chem Soc, Magn Reson, Proc Natl, Academic Press, Chem Phys, Mol Biol, Curr Opin, Drug Discov, Phys Lett, Acad Sci, Nucleic Acids Res, Ain Chem, Clarendon Press, Comput Sci, Chem Lett, Linking Library, Nat Struct, Oxford University Press, Phys Chem, Protein Sci, Struct Biol, Annu Rev, Case Study of Neuropeptide New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Copyright | Table of Contents | Excerpt | Index | Back Cover | Surprise Me!
The introduction of stable isotopes into proteins has significantly reduced the time requirements for structure elucidation of biomolecules. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
torsion angle dynamics algorithm, recoupling sequences, predicted dipolar couplings, perdeuterated proteins, ambiguous distance constraints, chemical shift list, algal hydrolyzate, paramagnetic relaxation enhancement, primary screening hits, repulsive core radii, orienting media, alignment tensor, favorable relaxation properties, using dipolar couplings, dipolar coupling data, backbone cyclization, protein ligation, dipolar coupling value, isotope filtering, split intein, bipolar couplings, residual dipolar couplings, torsion angle constraints, chemical shift mapping, ligand resonances Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Methods Enzymol, Chem Soc, Magn Reson, Proc Natl, Academic Press, Chem Phys, Mol Biol, Curr Opin, Drug Discov, Phys Lett, Acad Sci, Nucleic Acids Res, Ain Chem, Clarendon Press, Comput Sci, Chem Lett, Linking Library, Nat Struct, Oxford University Press, Phys Chem, Protein Sci, Struct Biol, Annu Rev, Case Study of Neuropeptide New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Copyright | Table of Contents | Excerpt | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 11
books:
See all 11 books this book cites
8
books
cite this book:
See all 8 books citing this book
- Nuclear Magnetic Resonance (Specialist Periodical Reports) by R. K. Harris on page 78, page 224, and page 340
- Principles of Nuclear Magnetism (International Series of Monographs on Physics) by A. Abragam on page 177, and page 306
- Amino Acid and Peptide Synthesis (Oxford Chemistry Primers, 7) by John Jones on page 280
- Numerical Recipes: The Art of Scientific Computing by William H. Press on page 306
- Cell-Free Translation Systems by A.S. Spirin on page 38
See all 11 books this book cites
- Protein NMR Techniques (Methods in Molecular Biology) (Methods in Molecular Biology) by A. Kristina Downing on page 159
- NMR Spectroscopy of Glycoconjugates by Jesús Jiménez-Barbero in Front Matter
- G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity (Methods and Principles in Medicinal Chemistry) by Roland Seifert in Front Matter
- G Protein-Coupled Receptors in Drug Discovery by Kenneth H. Lundstrom on page 155
- DNA and RNA Binders, From Small Molecules to Drugs (2-Volume Set) by Martine Demeunynck in Front Matter
See all 8 books citing this book