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This digital document is an article from Human Biology, published by Wayne State University Press on August 1, 1994. The length of the article is 2991 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: A mismatch distribution is a tabulation of the number of pairwise differences among all DNA sequences in a sample. In a population that has been stationary for a long time these distributions from nonrecombinant DNA sequences become ragged and erratic, whereas a population that has been growing generates mismatch distributions that are smooth and have a peak. The position of the peak reflects the time of the population growth. The signature of an ancient population expansion is apparent even in the low-resolution mtDNA typings described by Merriwether et al. (1991). The smoothness of the mismatch distribution, an indicator of population expansion, is hardly affected by population structure, whereas mean sequence divergence increases in a pooled sample from highly isolated subpopulations.
Citation Details
Title: Signature of ancient population growth in a low-resolution mitochondrial DNA mismatch distribution.
Author: H.C. Harpending
Publication: Human Biology (Refereed)
Date: August 1, 1994
Publisher: Wayne State University Press
Volume: v66 Issue: n4 Page: p591(10)
Distributed by Thomson Gale
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