The Parvoviruses (The Viruses) 1st Edition

by Kenneth I. Berns (Editor)

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ISBN-13: 978-0306414121

ISBN-10: 0306414120

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The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame- nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un- derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus genus, for instance, contains the defective adeno-as- sociated viruses (AA V), which require a coinfection with either an ad- enovirus or a herpesvirus for productive multiplication. Studies of AA V, therefore, necessarily impinge on our understanding of the control of macromolecular synthesis by the helper virus. Similarly AA V has been reported to inhibit the oncogenicity of both adeno-and herpesviruses and has been used as a probe of mechanism in these instances as well. Finally, AA V establishes latent infections in vivo and is the only mammalian DNA virus where a comparable model system has been established in cell culture. This system has allowed study of the mechanism of latent infection at the molecular level.

The Parvoviruses (The Viruses)

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Product Details

Series: The Viruses
Hardcover: 424 pages
Publisher: Springer; 1 edition (January 31, 1984)
Language: English
ISBN-10: 0306414120
ISBN-13: 978-0306414121
Product Dimensions: 9.6 x 6.6 x 0.8 inches
Shipping Weight: 1.7 pounds
Average Customer Review: Be the first to review this item
Amazon Best Sellers Rank: #6,333,662 in Books (See Top 100 in Books)
- #1923 in Books > Textbooks > Medicine & Health Sciences > Medicine > Basic Sciences > Microbiology
- #2302 in Books > Textbooks > Medicine & Health Sciences > Medicine > Clinical > Infectious Diseases
- #3417 in Books > Medical Books > Medicine > Internal Medicine > Pathology > Diseases > Viral