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Man and Microbes: Disease and Plagues in History and Modern Times (Paperback)

by Arno Karlen (Author) "This book is about new plagues, survival, and the dance of mutual adaptation we carry on with our microbial fellow travelers..." (more)
Key Phrases: crowd diseases, disease pool, virgin populations, United States, Old World, North America (more...)
4.5 out of 5 stars See all reviews (16 customer reviews)

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Editorial Reviews

Amazon.com Review
Whereas many popular books on microbes focus on contemporary pathogens and emerging epidemics, Arno Karlen's Man and Microbes provides a historical look at the coevolution of humans and microorganisms. Karlen speculates that infections are integral to the process of life itself, that the mitochondria in every animal cell, for instance, are likely descendants of infectious agents. He then traces the development of man from primitive hunter-gatherer to urban dweller to world traveler, pointedly analyzing how socio-ecological changes have contributed to the changing incidence of disease. With amazing detail, Karlen describes the origins of historical plagues (smallpox, cholera, influenza, polio, and others) as well as the emergence of scourges such as hemorrhagic fever (Ebola and its cousins), Lyme disease, Legionnaires' disease, and even the deep mysteries of retroviruses such as HIV.

From Publishers Weekly
Karlen (Napoleon's Glands) has produced a disturbing, succinct, compelling report on the current global crisis of new and resurgent diseases. Covering cholera, leprosy, cancer, AIDS, viral encephalitis, lethal Ebola fever, streptococcal "flesh-eating" infections and a host of other killers, he shows how the present wave of diseases arose with drastic environmental change, wars, acceleration of travel, the breakdown of public health measures, and microbial adaptation. In the book's first half, he entertainingly charts humanity's relationship with microbes, from the earliest hominids' probable encounters with bubonic plague to hunter-gatherers' comparative good health, the explosion of sickness in Bronze Age cities and the spread of infections with trade, conquest and empire. Karlen concludes that today's epidemics are part of an ancient pattern-whenever people make radical changes in their lifestyle and environment, disease flourishes. He suggests that improved surveillance could help defuse the crisis we face now.
Copyright 1995 Reed Business Information, Inc. --This text refers to an out of print or unavailable edition of this title.

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25 of 27 people found the following review helpful:
4.0 out of 5 stars "In the city, famine and pestilence shall devour him", February 25, 2002
So the author of revelation saw the lethal side of cities (quoted on page 48), or as Mr Arno Karlen better describes-"as farmers and villagers began crowding into cities, this immunologically virgin mass offered a feast to germs lurking in domesticated animals, wastes, filth, and scavengers" (page 48).

This book provides a reasonable overview of germs and social history. Mr Karlen traces the development of agriculture and cities to the development of 'crowd diseases', jumping ship from previous group species such as horses, pigs, ducks, rats, etc, or mutating from previously benign forms, or appearing and diappearing from nowhere, leaving little trace. As far as other species influence goes-that old friend the dog is suggested to have contributed no less than 65 diseases to homo sapien (page 39), with 45 from cattle, and 35 fom horses.

The reader will find discussion on the likely origins and developments of eg measles (possibly from distemper in dogs, although Diamond in the book "Guns Germs and Steel" suggests cattle), smallpox (dogs or cattle), influenza (pigs and ducks), common cold (horses?), scarlet fever, typhus, bubonic plague (fleas), syphilis, gonorrhea, cholera (lives in water), AIDS (probably chimps), malaria (mosquito), tuberculosis, leprosy, legionaires disease, and a host of others. Various historical calamities are described such as:

- Athens which lost 1 in 3 people in 430 BC, (unknown- possibly measles, typhoid, scarlet fever, smallpox), and which ended the so-called 'golden age' of Greece.
-AD 164-180+ Roman empire-4-7 million deaths, (probably smallpox),
-540 AD+ bubonic plague-halving Europes population over the next 150 years,
-200 BC to 200 AD smallpox and measles ravaged China and Japan (many other times also),
-several waves-657-1551 AD-"sweating sickness" (appears to have gone extinct),
-AD 125- 1 million deaths in north Africa alone (?measles)
-AD 79 Rome-Anthrax, or possibly malaria
-later 20 century-present-AIDS, -millions and climbing,
-1348-1352 AD bubonic plague, with several waves- 25 million plus in Europe, more in the east,
-1800s- several waves-cholera and yellow fever in Europe,
-1492-1800s+-Americas estimated 90 million deaths of indigenous populations,
-1918, influenza-around 40 million.
-many others.

Older calamities are often less well documented in eg Africa, India, China, etc. 20th century examples are many, often small, and often a 'new' disease-eg page 6 lists a partial list of around 20 'new' diseases in latter 20 century outbreaks, including ebola and legionaires.

Readers will be interested to read of the social changes which were influenced by many of these outbreaks, such as the tragic conquest of the Europeans into the Americas, and the decline of the Roman Empire-partly due to successive ravages of various plagues. As the empire expanded it brought back numerous germs, something which was forgotten by the time partly immune explorers brought them again to other lands in the second millenium AD.

Modern examples and resurgences are also discussed such as Lyme disease, mad cow disease, AIDS, tuberculosis, malaria, legionaires, etc. Most diseases tend to decline over time as a population becomes immune, (eg Syphilis, since about 1492) but a few seem to go the other way-eg polio and tuberculosis-ie they increase in severity. Modern examples which make medical specialists nervous in the modern age are also described, such as hantaviruses, ebola, TB, hepatitus, AIDS -especially of mutation, and malaria, but there are a host of others.

The thing I find fascinating, and sad about this book, is the complexity of the immune system, and how these diseases originate and proliferate. Many have jumped from other species, some have always been with us- but ocassionally mutate into a virulent form. Some have always been around in water or elsewhere, and mutute/evolve occassionally -like Legionaires disease. It is an ever-present war, and one which has greatly influenced history.

The book provides a stark analysis of human history and the ruthlessness of life with germs, but despite the general negativity of this book, one must also appreciate how far we have come, and in how many ways we succeed against these diseases, and continue to succeed. New diseases are inevitable, but Ridley suggests in the book "Disease" that the future may well be in DNA vaccines. One can only hope.

One disapppointment is the lack of deeper medical explanation on eg how diseases function, and why some are more effective than others, and various aspects of the immune system etc. There is a distinct lack of deeper medical analysis, for those like myself who want a deeper medical investigation.

Recommended for those who are interested in how sickness has affected history, but not so much *why* we get sick, in any great detail.

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13 of 13 people found the following review helpful:
5.0 out of 5 stars A disease progress report at the end of the 20th Century, May 3, 2000
By Anthony R. Dickinson (WashU Med School, USA) - See all my reviews
(REAL NAME)   
Published in the UK as `Plague's Progress: A Social History of Man and Disease', Karlen provides the reader here with an excellent introduction to the topic of the natural, as well as social history of the most common human life-threatening diseases. Covered here are all the usual (as well as some more unusual) suspects, from mediaeval plagues to AIDS and CJD; from soldiers not warring due to disease outbreak, to war outbreak being signalled by disease. Although there are some one-liners for conspiracy theorists with regards man-made disease vectors, the principal thesis of this book is that new pandemic and epidemic outbreaks of disease result from changes in human and other microbe host behaviours and the situated environment(s) in which these changes take place. For example, changes in land usage, habitat (as much in the `home' as in the field), species interactions, development & redevelopment, etc.., necessarily give rise to novel ecological niches available for exploitation by any number of host/pathogenic organisms and disease vector transmission pathways. Karlen is correct to further emphasise the point that such opportunist developments and novel disease situations arise from constructive events (aircraft transportation of secondary hosts, air-conditioner habitats and overuse of antibiotics) as much as from destructive events (deforestation and animal extintions give rise to traditional host-parasite species shifts). A useful summary table is provided of the time-line of recent life-threatening contagious diseases, but I found myself annotating the margin with a few more details concerning each (e.g., secondary host - rodent, cattle, insect; virus/bacteria/protozoan organism etc) - all of which was nonetheless available in the text of the book. Although a delicate subject for those suffering from any of the conditions described here (both directly and by atives/carers nearby), Karlen presents both an informative and entertaining dialogue for the newcomer to the topic of disease - clearly accessible and in non-technical language for the lay reader looking for a clearer understanding of a life-threatening phenomena that is likely to always be with us in some form. If I were to have any grumbles, they would relate solely to a few of my own particular interests in a couple of theories given short thrift here. Such might include exposures to man-made/altered disease vectors (cf: Moreno; whether they be designed for plant, insect or human control via innoculation) and the theories put forward by writers such as Lyn Margulis (symbiotic evolution) and the more esoteric writings of Hoyle & Wickramasinge or Francis Crick. So much better informed concerning the role of natural, political and historical events influencing pandemic and epidemic disease evolution, following our reading of this Kaplan book one might be in a better position to explain our forgetting of the 1918 flu pandemic, the last widespread disease within living memory, taking a total number of lives far greater than the toll of the last century's World Wars combined. How, and whether, such information will be used to manage the future of our social behaviour, demography, medical practice, and our continuing scientific research culture, we must await the coming years to find out.

References:

Crick: Life Itself.

Hoyle & Wickramasinge: Diseases from Space; Evolution from Space.

Margulis & Fester: Symbiosis as a source of Evolutionary Innovation.

Margulis & Sagan: Microcosmos.

Moreno: Undue Risk.

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11 of 11 people found the following review helpful:
4.0 out of 5 stars Great Examination of Disease and History, October 3, 2000
By Tracy Davis (California, United States) - See all my reviews
(REAL NAME)   
In Arno Karlen's "Man and Microbes", history is approached through the relationship of disease to mankind, starting with the first humans to the present. This is a fascinating examination of the microscopic world's impact on the macroscopic world. The origins of some diseases, such as cholera, the 'black plague' and AIDS is covered, as well as epidemics affecting only small parts of the world. Throughout the book, it is emphasized that we could be on the brink of new pandemics -- the most obvious example is AIDS -- that will not only dramatically reduce population, but change our world view and lifestyle. Modern pandemics and our responses to them are compared and contrasted to past pandemics, with the resulting opinion that although we live in a technologically savvy world, our reactions of fear and panic have not changed all that much. My only minor criticism by the last quarter of the book is too much repetition; I found my mind wandering and was a little confused by the end. However, I think that this is an excellent book for those interested in interdisciplinary (biology and history) studies.
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Most Recent Customer Reviews

5.0 out of 5 stars Man and Microbes review
I enjoyed reading this book. It was well written. The author made it so interesting and educational that even if there are no colored pictures in it on every page, I still read... Read more
Published 14 months ago by MGH of Kodiak

4.0 out of 5 stars Recommended Read
Karlen's "Man and Microbes" is a good read, especially for the novice biology reader. I think everyone interested in the subjects of microbiology, medical history, and... Read more
Published on May 12, 2007 by T. Gale

5.0 out of 5 stars fascinating, educational, and alarming
"Man and Microbes" is a good title for this book. Over time, man's relationship with microbes has changed as human populations have grown, moved, changed from hunter-gatherer to... Read more
Published on June 15, 2006 by Sammy Madison

4.0 out of 5 stars Great Intro, But Lacking in the Details -
First and foremost, this book is an oustanding, fantastic introduction to the world of infectious diseases. Because of two factors, however, much informatoin is lost. Read more
Published on January 27, 2005 by L. Berk

5.0 out of 5 stars The Medical History of Mankind
This book is about the new diseases that plague mankind, an epidemic of epidemics. There was a faith in social, scientific, and technological progress dating from the 19th century... Read more
Published on November 30, 2004 by Acute Observer

5.0 out of 5 stars A Fascinating and Frightening History of Disease
Arno Karlen's "Man and Microbes" is an informative and well-written account of the history of disease that is accessible to specialists and non-specialists alike. Read more
Published on June 14, 2004 by Lady Murasaki

4.0 out of 5 stars A good read on an important topic, but lacking in detail
The author presents a convincing series of anecdotes to support his hypothesis that many infectious diseases result from environmental and cultural changes. Read more
Published on July 26, 2003 by James

5.0 out of 5 stars Very good overview of the history of infectious diseases
After "Plagues and peoples", a classical book by William McNeill that first appeared in 1975, I read this book, which was first published in 1995. Read more
Published on July 1, 2003 by Linda Oskam

5.0 out of 5 stars A Microbe Primer!
This book briefly sketches plagues and infectious diseases, from ancient times and of earliest recorded writings, to the present day (1995). Read more
Published on February 14, 2001 by Kevin Spoering

4.0 out of 5 stars Thought Provoking: A Germ's Point of View
Arno Karlen's attempt to chronicle the successes and failures of man's quest to survive in a world in which he is constantly battling with disease, results in an engaging and... Read more
Published on November 30, 2000 by Jose & Mary Betancourt

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