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Arthritis - Can it be reversed????? HELP


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Posted on Dec 9, 2012 1:02:42 PM PST
I found this article interesting on stem cell research - Scientists at Novartis AG (NOVN) have discovered a compound that spurred cartilage growth from stem cells to fix damaged joints of mice, a finding that may point to a novel therapy for the arthritis that afflicts most elderly.
Researchers tested 22,000 drug-like molecules using a robotic screen, applying each one to bone marrow stem cells in tiny laboratory dishes. One compound, dubbed kartogenin, promoted the development of chondrocytes, cells that become cartilage, according to the report in the journal Science.
Researchers injected kartogenin into the damaged knee joints of mice, which prompted cartilage regeneration, improved symptoms and lowered levels of proteins and collagen fragments linked to damaged joints. The results suggest a unique, though early-stage, way to regulate cartilage and possibly repair some of the damage from osteoarthritis, the breakdown of cartilage that leads to joint failure, the researchers said.
"We found this molecule that can take stem cells that are already in the joint, and differentiate them into chondrocytes," cartilage cells that secrete the squishy elastic substance that protects the joints, said Kristen Johnson, a regenerative medicine researcher at the Genomics Institute of the Novartis Research Foundation in San Diego. "We're excited about the biology because it's a new way of targeting the stem cells, but you can't emphasize enough what an early stage of drug discovery this is."
Additional work is needed to understand exactly how kartogenin works and the basic biology it affects before more animal studies are done, said Johnson, who is also part of the Novartis Institutes for BioMedical Research. Novartis is based in Basel, Switzerland.

In reply to an earlier post on Dec 8, 2012 11:03:02 PM PST
zilverb says:
Excellent!

In reply to an earlier post on Dec 8, 2012 10:59:16 PM PST
zilverb says:
You have done as I have done! I am so happy for you! You did a marvelous job explaining this.

In reply to an earlier post on Dec 8, 2012 10:54:34 PM PST
zilverb says:
When you try it and it works or works better than mainstream drugs then it is not quackery.

In reply to an earlier post on Dec 8, 2012 10:52:06 PM PST
zilverb says:
Go alcaline.

In reply to an earlier post on Dec 8, 2012 10:51:09 PM PST
zilverb says:
Thanks for sharing! This is amazing!

In reply to an earlier post on Dec 8, 2012 9:42:49 PM PST
zilverb says:
Congratulations!

In reply to an earlier post on Dec 8, 2012 9:40:55 PM PST
zilverb says:
Great post!

In reply to an earlier post on Dec 8, 2012 9:40:15 PM PST
zilverb says:
Great post! You know the way!

In reply to an earlier post on Dec 8, 2012 9:35:02 PM PST
zilverb says:
Mary, I made much progress with this very thing. The raw honey did not add much. Bragg's books are wise.

In reply to an earlier post on Dec 8, 2012 9:33:14 PM PST
zilverb says:
In mainstream medicine, you are correct. Otherwise, you are not. You are restricted by what you can do; therefore, you do not try to look. The rest of us have no such restrictions put onto us; therefore, we do not limit our thinking and actions in this way.

Posted on Oct 5, 2012 4:19:56 AM PDT
What about the old raw apple cider vinegar drink with raw honey? Dr. Bragg's books state it clears out the arteries, capilliaries to the joints and this helps reverse arthritis.

In reply to an earlier post on Oct 4, 2012 4:30:48 PM PDT
E. Platas says:
That was great information. Thank you so much for explaining it all so well.

In reply to an earlier post on Oct 4, 2012 2:21:03 PM PDT
Last edited by the author on Oct 4, 2012 2:21:48 PM PDT
bill yancey says:
I hate to be the bearer of bad news but realistically, you need to know this: There is no cure for osteoarthritis of the spine (or other body parts), the most common cause of chronic low back pain. Your lumbar spine is a weight bearing structure, similar to your knees, your hips, and ankles. (Reminder, this discussion has very little to do with your neck or thoracic spine; they have different purposes.)

There are some blogs and websites that insist you can "rebuild" your back. That's not possible for people with osteoarthritis. People with sprains and strains that have not progressed to osteoarthritis can "rebuild" or strengthen their back. There are ways of decreasing pain and cutting down on re-injuries, too. However, the only person who could "rebuild" an osteoarthritic back would be a surgeon, and he is only resurfacing or remodeling. The structure is what it is.

Osteoarthritis is the chronic degeneration of the structures that make up the spinal column: mainly the discs, the cartilage, and the ligaments. The discs dehydrate and collapse; the cartilage cracks and breaks down; the ligaments become stiff and less flexible. Even without external factors caused by overwork, this process is related to aging. Until someone comes up with a fool proof method of reversing aging, osteoarthritis will not be reversible.

I'll use the knee as an example of a weight bearing joint. The same things I will mention here apply to the hips, lower back, and ankles.

There aren't many people claiming they can rebuild your knees, although doing so may be easier for the surgeons than rebuilding your back. A serious knee injury, say a torn ACL (anterior cruciate ligament), leads invariably to osteoarthritis of the knee. This is true whether the ACL is reconstructed or not. The osteoarthritis (degeneration of the cartilage, collapse of the joint space, loss of flexibility of the ligaments) is inevitable. The time it takes to degenerate can be affected by life style, however. Serious injury makes the joint too mobile, allowing structures to move too far stressing other structures, leading to premature aging.

At age 19, I had my right knee severely damaged playing spring football in college. I tore the MCL (medial collateral ligament), the medial meniscus (cartilage), and the ACL. In 1967, they didn't surgically repair ACLs like they do today. They did remove the damaged cartilage, however. MCLs heal on their own; they have good blood supply. ACLs do not heal, having poor blood supply. The orthopedic surgeon told me that I didn't need an ACL. As long as I kept my quadriceps muscles strong, he said, my knee would function normally. I believed him and I spent a lot of time exercising my legs. I had some problems, but overall, my knee has served me well. It has been essentially pain free for 45 years. I played soccer until I was 45. At 65, I continue to run 5-8 miles twice a week. However, if you x-ray my knee, it looks like it should hurt a lot. I have bone spurs, a flattened joint, and nearly bone on bone collapse of the joint space -- a typical severe osteoarthritis x-ray.

Exercise of joints with osteoarthritis is important. This is true for backs, hips, knees, and ankles. Motion is the lotion, as one neurosurgeon I met told me. Under-exercise and over-exercise can lead to more degeneration and pain. When an ACL is repaired, the athlete can continue to exercise. His knee joint will still develop osteoarthritis, but more slowly than if he stopped exercising. When you suffer a back injury, motion is an important part of recovering, and keeping the muscles strong in your abdomen and back help protect you from further injury. Gradual onset of osteoarthritis is almost inevitable with a severe injury, but moderate exercise delays the progression. So, even if osteoarthritis can't be cured, it can be delayed and the pain minimized. Being active is important.

In addition to being active, decreasing the load your lower spine has to bear also slows the progression of osteoarthritis. So if you are overweight, losing weight helps your back. Avoid lifting very heavy objects.

Osteoarthritis is a chronic, progressive medical condition with no cure. That does not mean having this disease is a death sentence. Many people live very well with it. It's not reversible, but you can slow its progression if you remain active. To minimize discomfort lose weight and don't overdo it.

Bill Yancey, MD
Whatyourdoctor dot blogspot dot com

In reply to an earlier post on Jun 1, 2012 9:33:26 AM PDT
Thank-you for all the advice. It helps.

In reply to an earlier post on May 16, 2012 9:51:12 PM PDT
pounder says:
Edgar Caycee was a huge advocate of keeping the body in an alkaline state in order to prevent and reverse diseases and other problems with health.

Posted on May 16, 2012 5:37:53 PM PDT
The book is avaliable here at amazon:

The New Arthritis Cure: Eliminate Arthritis and Fibromyalgia Pain Permanently

Posted on May 16, 2012 12:51:09 AM PDT
Hello, Pick up a copy of Bruce Fife's book, "The New Arthritis Cure", It deals with why we get the disease, and how to cure it with diet, etc. I cannot tell you what a Godsend this book has been for my husband. Blessings to you...

In reply to an earlier post on May 15, 2012 6:33:08 PM PDT
ab says:
It's URIC acid, and that is only one type of arthritis. There are many types including osteo, inflammatory (such as rheumatoid or psoriatic), infectious (Lyme), etc.

In reply to an earlier post on May 15, 2012 2:05:35 PM PDT
E. Platas says:
Cut down on sugar and processed grains such as white flour, white rice, corn, etc. Yeah, I know, all the good stuff. Seriously, look up anti-inflammatory diets for more info, but the basic idea is to avoid as much refined and processed foods as possible. Let me say that I have a huge sweet tooth and I love baked goods in particular. However, I have learned the hard way that when I overdo it with the sweets and processed foods within a day or two my joints swell and the pain and fatigue come back. Also be sure to take a high dose of pharmaceutical grade Omega 3 (NOT 6) fish oil supplement. I've been using Nordic Naturals Ultimate Omega, 1,000 mg Fish Oil, 180 Soft Gels for about two years now and really like the brand. Omega 3 oils, found in wild (not farmed) fish, walnuts and flax-seed are potent anti-inflammatories. On the other hand, Omega 6s, found in abundance in corn, soy and most commercially prepared foods are highly inflammatory--exactly what those of us with arthritis don't need. You may want to check out The Fat Resistance Diet: Unlock the Secret of the Hormone Leptin to: Eliminate Cravings, Supercharge Your Metabolism, Fight Inflammation, Lose Weight & Reprogram Your Body to Stay Thin- right here on Amazon. You can read enough of the introduction to get an idea about the kinds of foods that are recommended. (The title focuses on weight loss because foods that cause inflammation apparently are also the foods making us fat.) Good luck.

In reply to an earlier post on May 15, 2012 12:33:06 PM PDT
OldAmazonian says:
http://www.ncahf.org/articles/c-d/dmso.html

In reply to an earlier post on May 15, 2012 8:54:47 AM PDT
B. Jones says:
See the book: Lose Weight and Eat All You Want -- written by a Hannah Yoseph, MD. The diet is written also for sufferers with autoimmune diseases like arthritis.

Posted on May 12, 2012 4:51:18 AM PDT
J. White says:
Neocell Collagen Type 2 Immucell Complete Joint Support Capsules, 2400 Mg, 120 Count

Posted on May 12, 2012 4:41:07 AM PDT
J. White says:
There have been two recent articles in Life Extension magazine on preventing arthritis and reversing symptoms using collagen II. Try Immucell, available here on amazon. This is one of the articles

http://www.lef.org/magazine/mag2012/feb2012_Protect-Joints-Autoimmune-Attack_01.htm?source=search&key=collagen%20II

Posted on May 11, 2012 10:56:24 AM PDT
Last edited by the author on May 11, 2012 10:59:04 AM PDT
Thanks. Is there a more natural type, I get migraines from silfites if thats what's in it? I have a neck injury from a dishonest chiropractor. Some days so stiff.
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Discussion in:  Health forum
Participants:  24
Total posts:  40
Initial post:  May 6, 2012
Latest post:  Dec 9, 2012

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