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which is best Resveratrol product (not too expensive)?


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Initial post: May 9, 2012 1:27:35 PM PDT
I just ordered 500 MG Resveratrol Extreme Juice Capsules, which appears to have good reviews (although some say that it may not have much TRANS resveratrol, which is the most effective). Should I cancel this order and order another resveratrol product? please give me details as to what's the best

Is resveratrol truly effective for anti aging, more energy, etc? I'm so confused by all the opinions on the internet!

Posted on May 10, 2012 2:57:08 AM PDT
You are taking a potentially toxic dose of resveratrol at 500 mg. The body perceives resveratrol as a toxin and therefore its ingestion activates the body's inborn antioxidant defenses, producing enzymatic antioxidants catalase, glutathione, superoxide dismutase, heme oxygenase as well as adenosine and nitric oxide. This is known as hormesis -- a little bit of a toxin produces a beneficial response, or what Paracelsis said many centuries ago, the dose makes the poison. At low dose resveratrol is an antioxidant (binds to copper) and at high dose resveratrol promotes oxidation (releases copper). In studies performed in animals, the human equivalent of 175 mg reduced the size of an experimentally induced heart attack, but ten times that amount (1750 mg) actually increased the size of a heart attack. Most of the companies making resveratrol pills do not science savvy. More is not better. Refer to www.resveratrolnews.com for more information. --Bill Sardi

In reply to an earlier post on May 10, 2012 6:47:59 AM PDT
I appreciate your comment, and it truly is incredibly FRUSTRATING that it's so damn hard to get good info on revesteral. THe comments on amazon make this brand seem very good, but your comment scares me, so I'm pretty much confused on where to go next.
What particular brands are the best and not 90 dollars a month (it sounds like TRANS revesteral is most important, so which brands have enough of this to matter?)? when I google resverteral reviews, each website gives COMPLETELY different reviews of different brands as the "best." Which review and brand can I trust? thanks

In reply to an earlier post on May 10, 2012 6:58:38 AM PDT
Resveratrol Reviews is a fraud. It is presented as a front for a particular brand or brands that the website owner receives a kickback from in the form of a click fee or affiliate fee. This is not disclosed. These review sites have not conducted any studies and often mischaracterize products.

Posted on May 10, 2012 10:07:37 AM PDT
J. White says:
I take NeoCell Resveratrol on subscribe and save. Not only a great price but made from French Muscadine grapes, which is what was used in the original research. Check your lables! Manufacturers put grapes as decoration on their labels, then use cheap Japanese knotweed! If you want to see research, google Life Extension Magazine then search there for resveratrol.

http://www.amazon.com/gp/product/B003O1K6N8/ref%3dox_sc_act_title_1?ie=UTF8&m=ATVPDKIKX0DER

In reply to an earlier post on May 10, 2012 10:28:34 AM PDT
While muscadine grape is a good natural source of resveratrol, it is provided in micrograms versus milligrams in extracts from botanical sources such as Giant Knotweed. Micrograms of resveratrol do not provide sufficient biological action. Wine, which is an alcohol extract of grape skin, yields milligrams of resveratrol is attributed to a reduction in mortality from heart disease, whereas grape juice is not. Resveratrol is simply window dressing on many dietary supplement labels. The product you mention does not list the actual amount of resveratrol provided.

Posted on May 10, 2012 10:31:23 AM PDT
OldAmazonian says:
Maybe it would be more enjoyable and beneficial to simply enjoy a glass of red wine with supper every day.

Posted on May 10, 2012 10:35:56 AM PDT
Look, I comment here to help consumers. I am the managing partner of a company that makes a commercially available resveratrol pill that has undergone extensive testing and has published studies. But my experience is that while consumers love the science, they buy with their pocketbook. There are so many on limited incomes. This results in consumers buying ineffective products. I would just try to find a name brand and take theirs, no more than 50-100 mg. Hopefully the product is labeled correctly and you will get your money's worth. --Bill Sardi

In reply to an earlier post on May 10, 2012 10:38:02 AM PDT
OldAmazonian says:
What is your opinion of Swanson's own brand of resveratrol?

In reply to an earlier post on May 10, 2012 10:47:31 AM PDT
Last edited by the author on May 10, 2012 10:54:55 AM PDT
OldAmazonian says:
Good site here, named after a great humanitarian scientist who won Nobel Prizes in two unrelated fields:

http://lpi.oregonstate.edu/nswltrmain.html

http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/

Posted on May 10, 2012 11:12:24 AM PDT
Last edited by the author on May 10, 2012 11:26:48 AM PDT
Ryan Huyck says:
Wow, William Sardi is completely wrong. As a published molecular biologist, I can tell you his information about resveratrol being "perceived as a toxin" is absolutely false (resveratrol is metabolized by the cytochrome p450 complexes like the majority of all compounds one ingests, or even produces naturally). Futhermore, resveratrol is safe above 2 grams per day, and in fact no known upper limit exists. There are no known adverse side effects with resveratrol (other than aromatase inhibition, which can like all aromatase inhibitors in rare circumstances cause joint pain in individuals who do not receive enough sunlight). In fact, 2 grams per day of resveratrol is about the minimum for the average person to take to get the maximum benefits as seen in scientific studies (such as muscle strength, control, and coordination increase). This is of generic trans-resveratrol without any vehicle to help its absorption such as oils. Lower doses of resveratrol (down even into the low mg's) still give you many of its other benefits, such as Sirt1 activation through AMPK, anti-cancer, anti-oxidant, anti-viral, anti-bacterial, and anti-neurodegeneration activities.

500 mg of resveratrol is more than safe! Resveratrol is not a toxin in any way, shape, or form!

Additionally, I would also like to point out that William Sardi's cited study about resveratrol and heart attacks (ischemia, to be exact), was done on isolated rat hearts, not orally given to an actual animal. The heart attacks were then induced directly by the researchers. That is not a natural situation, nor should anyone be injecting doses of resveratrol directly into the heart as with that study. Also, the antioxidant production boost by resveratrol is mediated through Sirt1/AMPK, and is of high benefit (part of its anti-aging effect). On his last claim, resveratrol has a -very weak- affinity for copper (it is not even proven that resveratrol binds copper in vivo), below that of aspirin which is a copper chelator. In fact most people are copper deficient and need higher intakes of it than we get (up to 9 mg per day), but resveratrol can never "release copper" as copper is not part of the resveratrol structure (and contrary to what William stated, higher amounts of a chelator binds more of a metal, it never "releases" it).

Finally, note that only about 1% of any resveratrol you take orally will actually be absorbed by the body. Taking resveratrol with oils will help this absorption. Trans-Resveratrol is also the only biologically active version, so whatever supplement you get make sure it is reporting the amount of trans-resveratrol.

Revgenetics makes some good resveratrol supplements, but they are really expensive (40 bucks for a month supply on average). Most other resveratrol supplements are all the same, but look for the highest purity of trans-resveratrol in the highest amounts, as other random extracts in some low purity supplements may not be good for you.

In reply to an earlier post on May 10, 2012 11:20:47 AM PDT
No, you are wrong by your own definition. Why does the liver produce cytochrome p450 enzymes? Because it is detoxing.
And the liver binds resveratrol to suflate and glucuronate to detox it and shuttle it eventuall to the kidneys.
Stop trying to use your "molecular biologist" title to claim what is utterly false.
Low dose toxins work by a process called hormesis -- look it up. Read here: http://www.ncbi.nlm.nih.gov/pubmed/21115567
More confusion, no wonder no one wants to take these pills.
So much for molecular biologists. If you take the dose he recommends it will generate free radicals.
Studies also show about 75% of resveratrol is orally absorbed ( http://www.ncbi.nlm.nih.gov/pubmed/21261636 )

Bill Sardi

In reply to an earlier post on May 10, 2012 11:42:16 AM PDT
Ryan Huyck says:
The liver produces p450 to solubilize substances. There are many compounds your body makes itself that are catabolyzed by p450s so they can be eliminated from the body. P450s are permiscuous, they don't target something because it's "a toxin". They target anything they can react with in the first place. The sulfate and glucuronate modifications the p450s give resveratrol increase its solubility in the blood (also inactive it) so it will be eliminated; it's a simple part of the metabolism and has -nothing- to do with toxins. Almost all medicines for instance are modified by p450s, and you'd be hard pressed to find a compound that isn't targeted by some protein in the p450 family.

Also, William, did you read your own link? From that last paper you posted "Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%".

The bioavailability of orally taken resveratrol is known to be around 1%, that's it. Most of it is converted into other compounds -before it even makes it into your blood stream-, by the epithilial cells lining your intestines. (see http://www.ncbi.nlm.nih.gov/pubmed/12628442 (mice), http://www.ncbi.nlm.nih.gov/pubmed/22079044 (dogs), and finally http://www.ncbi.nlm.nih.gov/pubmed/15830336 (humans). Notice how oral resveratrol uptake and bioavailability is treated roughly the same across all these organisms)

Now, this can be increased by taking resveratrol with a fatty acid or other hydrophobic solution (like tween 80). Also, buccal absorption of resveratrol (letting it melt in your mouth and not swallowing it) can increase the bioavailability to ~30% or so. (see http://www.ncbi.nlm.nih.gov/pubmed/21668403 and http://www.ncbi.nlm.nih.gov/pubmed/21714124

Posted on May 10, 2012 11:44:55 AM PDT
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Posted on May 10, 2012 11:48:39 AM PDT
Resveratrol is perceived as a toxin, hence its glucuronidation and sulfation in the liver.
It is detoxed. Again, look up hormesis.
Quercetin added to resveratrol will inhibit the cytochrome p450 enzymes which then allows more resveratrol to be delivered.

In reply to an earlier post on May 10, 2012 11:52:55 AM PDT
Ryan Huyck says:
This is what you resort to William? No actual arguments or evidence to try to have a real, factual debate? You are posting links that don't even support your assertions. So, how am I, the one using actual science, a whacko?

I think you need some education in another matter too. Did you realize that p450s are part of the production of estrogen in your body (and other steroids)? Aromatase is actually P450aromatase and makes estrogen. So, is estrogen a toxin because it's a target of p450s? No. What about vitamin D, it is also a target of p450s for its breakdown and elimination by the body. Is vitamin D a toxin? No.

To be in the p450 family, you simply have to catalyze reactions using iron bound in heme. To learn more, I'll even refer you to wikipedia, as it has a good enough (though very basic) summary for beginners http://en.wikipedia.org/wiki/Cytochrome_P450 .

In reply to an earlier post on May 10, 2012 11:57:33 AM PDT
Last edited by the author on May 10, 2012 11:58:36 AM PDT
Ryan Huyck says:
For once you are actually saying something right! Quercetin does indeed inhibit two specific p450s (CYP3A4 being the biggest one) that target resveratrol. And indeed, quercetin can help increase the bioavailability of resveratrol, and synergize with some of its effects as seen in mice.

But then, you also continue to say what's absolutely false: resveratrol is not perceived as a toxin. It simply reacts very well with p450s and CYP3A4 especially. All the p450s care about is solubilizing substances (or really just reacting with whatever they can, such as in sterol biosynthesis), and resveratrol is highly hydrophobic. This has nothing to do with toxins or toxicity (which is defined as damaging the body and harming its functions). If anything, you could make an argument that quercetin is being a toxin by inhibiting the CYP3A4. However, CYP3A4 catalyzes the production of actual toxins that can cause cancer, and its inhibition is actually usually beneficial to the body. (CYP3A4 also catalyzes statins to be eliminated from the body, so pairing resveratrol or quercetin with statins is not a good idea without forethought, as it'll increase statin potency)

Posted on May 10, 2012 12:13:45 PM PDT
OldAmazonian says:
You guys should all enjoy a bottle of wine and stop the chest-thumping.

Posted on May 10, 2012 12:19:02 PM PDT
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Posted on May 10, 2012 12:20:18 PM PDT
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Posted on May 10, 2012 12:23:44 PM PDT
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In reply to an earlier post on May 10, 2012 12:25:05 PM PDT
Ryan Huyck says:
I have yet to see a study where live animals were able to be mega dosed enough to show any sort of toxicity. It just doesn't get absorbed in the trans-resveratrol form well enough. But I could have missed such a study.

Anything, whatsoever, is a toxin in high enough amounts. Water, vitamins, food. The things that allow us to live can kill us at super levels.

Still, your claim that 500 mg of resveratrol is a toxic dose is completely incorrect. 2 grams of resveratrol a day is not toxic, and that's the lower limits of the life span study in mice (equivalent to humans) that showed such remarkable beneficial effects by resveratrol. Many effects you can get at 500 mg, except for the muscle enhancing ones from the looks of it. The truth is, it is very hard to get -enough- resveratrol, and there have been many debates in the scientific literature over whether or not living organisms and people can take in enough resveratrol to give the benefits seen in the in vitro experiments (some researchers have gone far enough to claim resveratrol is of such low bioavailability that it's ineffective in vivo). That is utterly contrary to your claims as well.

Resveratrol is not "perceived as a toxin". The body doesn't "see" toxins. It simply carries out chemical reactions. Vitamin A is also targetted by p450's for degredation. Does your body perceive vitamin A as a toxin?

One has to look at these matters from the proper angle to be able to understand them in a constructive way. False lines of thought like "perceiving as a toxin" are detrimental to understanding what biology actually is and how the body actually functions (and also what a toxin actually is).

In reply to an earlier post on May 10, 2012 12:27:42 PM PDT
Last edited by the author on May 10, 2012 12:28:05 PM PDT
Ryan Huyck says:
Resveratrol very weakly "inhibits" CYP3A4 (hence why I mentioned not taking resveratrol with a statin, since statins are CYP3A4 targets (are statins therefore "perceived as a toxin" while saving your life, then?)). This inhibition is simply because while the p450 is catalyzing resveratrol's metabolite transformation, it can't be acting on something else, and since this reaction is slow, it slows down the metabolitic speed of CYP3A4 for other targets who have to get in line, such as statins.

Quercetin is much stronger an inhibitor. Pomegranate and grape fruit juice are far, far more potent inhibitors of p450s and CYP3A4. Is pomegranate and grape fruit a toxin? No. And both those juices have their health benefits.

In reply to an earlier post on May 10, 2012 12:36:52 PM PDT
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In reply to an earlier post on May 10, 2012 12:43:58 PM PDT
Last edited by the author on May 10, 2012 12:47:31 PM PDT
Ryan Huyck says:
That "poor guy" even stated he was "scared" by your false claims. And that's where this discussion has to come in. It's only continuing because you keep making bogus claims with no facts; easily shown false by actual scientific knowledge. 500 mg of resveratrol is NOT toxic. The more resveratrol (up to 2 grams a day) the better, as far as any research has shown so far.

For reference this is the study that showed resveratrol mimicing calorie restriction in mice http://www.ncbi.nlm.nih.gov/pubmed/18599363 . While it doesn't increase life span, it does increase health span. The mice are far healthier all the way to their dying day than the control mice, as the effects of the aging process were greatly reduced. Furthermore, the mice on the high resveratrol diet, which got the most benefits, were given about 204 mg of resveratrol per kg of body weight per day. To calculate the human equivalent dose for myself, with a weight of 63.3 kg, that comes out to 1.84 grams per day (multiply the amount the mice had by the kg of your body, then divide by 7 for the empirical equivalent calculation based on the difference in body volume and metabolic speed).

So, again, 500 mg of resveratrol is not toxic.

What supplement should that "poor guy" take? Whichever gives the most trans-resveratrol, in the highest purity, for the lowest cost in his budget range. There really isn't much difference in suppliers, but NOW foods makes an ok 50% blend. And revgenetics has the best resveratrol I have found, but also the most expensive.
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Discussion in:  Health forum
Participants:  58
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Initial post:  May 9, 2012
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