There are some great answers! I agree that the Bible is a given. "Uncle Tom's Cabin" was a great answer.
The first book that popped in my mind was:
It may not have changed the entire world, but it certainly altered American history.
I suspect the books that really changed the world won't be amongst the classics, or even in our modern world. When books alter people - then people alter the world. Those dime westerns full of misinformation and anti-Indian sentiment most likely changed perceptions and realities for many. The books about the romance of Africa sent explorers into the inland and changed the lives of the native population forever.
The Travels of Marco Polo - Complete [Illustrated]
Worked up the imagination of so many.
Mark Twain's books certainly changed the world but not in ways that seem earth shattering.
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