Okay, so there's something that's bugging me about a lot of studies related to "Vitamin D" and these forums seem to attract some really smart folks. (Hopefully this post will still get responses even though it doesn't involve religion or intelligent design.) So I'm posting here to see if anyone can help. So I can appreciate that some people have low levels of calcidiol (25,D3) and it's low levels of this stuff which is used as a marker of deficiency. Low levels of calcidiol correlate with all sorts of problems. One of those problems is arterial calcification and heart disease. And that's what's odd. Because arterial calcification seems more likely to be caused by over-conversion of 25 D3 to 1,25D3 and activation of the hormone D receptor (resulting in the destruction of the 1,25D3.)
Over-activation of the hormone D receptor, and not underproduction of 25-D3, seems a far more likely explanation for arterial calcification since activation of that receptor is involved in calcium absorption from the gut and also because activation of that receptor is involved in putting calcium into the blood from the bones.
This over-conversion of 25D3 to 1,25D3 could be caused by chronic inflammation.
This seems to be a much better explanation for why low 25D3 is linked to heart disease. But I have difficulty believing that I can see something so simple and the medical community has just missed it. So can someone prove me wrong using peer reviewed studies?
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