I believe we're converging with Andromeda at a rate of about 130,000 mph. That's a crawl in galactic terms.
When it happens, it's unlikely that humans would feel any effect, even if life on earth survives that long.
It's also possible that our sun and its satellites could be ejected from the our galaxy, the Milky Way, by dark energy from a distant supernova. We probably wouldn't notice that either, except for a brighter star and shifts in the star map over a few hundred thousand years.
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