I don't think so. I'm right handed but I use it with my left hand; it's sort of designed to replace the WASD part of the keyboard. With the added benefit of being 100% programmable while giving your thumb a bit more to do than press spacebar/left alt.
It's absolute bliss for MOBA games; I don't think I could enjoy playing them without it. The added camera control alone make it worthwhile in LoL/DoTA2.