Nope. There's some stuff they did I'm indifferent to, such as changing Robb's romance from a Westerling to a nobody. That doesn't effect the story all that much. In AGOT the scene between Ned and Jaime is not near as enjoyable as what HBO did, with the two of them going at it. The only thing I didn't particularly agree with was where Daenarys was in the House of the Undying and had her vision. They should have included the scene with Rhaegar, Elia, and Aegon VI. It's pivotal to what happens in the series. I'm sure HBO is going to incorporate the idea somehow, assuming the show isn't canceled. GRRM has told them how the story ends pretty much, so they most likely know how they would like to have everything pan out.