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Editorial Reviews
Product Description
Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approach are.
About the Author
Joachim Frank is an Investigator at the Howard Hughes Medical Institute. He is also Professor of Biomedical Sciences and Adjunct Professor of Biology at the State University of New York at Albany, Adjunct Professor of Biochemistry and Molecular Biophysics at Columbia University, Research Professor of Cell Biology at New York State University Medical School, and head of the Laboratory of Computational Biology and Macromolecular Imaging at Health Research, Inc., the Wadsworth Center.
Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approach are.
About the Author
Joachim Frank is an Investigator at the Howard Hughes Medical Institute. He is also Professor of Biomedical Sciences and Adjunct Professor of Biology at the State University of New York at Albany, Adjunct Professor of Biochemistry and Molecular Biophysics at Columbia University, Research Professor of Cell Biology at New York State University Medical School, and head of the Laboratory of Computational Biology and Macromolecular Imaging at Health Research, Inc., the Wadsworth Center.
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Inside This Book
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Key Phrases - Statistically Improbable Phrases (SIPs):
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multivariate data analysis and classification, different defocus settings, spatial frequency radius, segmentation eigenvector, australis hemocyanin, interimage variance, angular refinement, differential phase residual, axial astigmatism, amplitude falloff, defocus series, projection matching, angular reconstitution, defocus range, variance map, ascendant classification, tilt geometry, data collection geometry, wave aberration function, experimental projection, stained molecules, hemocyanin molecule, molecule projections, defocus spread, methylamine tungstate Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biophysical Society, Blackwell Science Ltd, Cell Press, Walter Hoppe, Macromolecular Assemblies Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
multivariate data analysis and classification, different defocus settings, spatial frequency radius, segmentation eigenvector, australis hemocyanin, interimage variance, angular refinement, differential phase residual, axial astigmatism, amplitude falloff, defocus series, projection matching, angular reconstitution, defocus range, variance map, ascendant classification, tilt geometry, data collection geometry, wave aberration function, experimental projection, stained molecules, hemocyanin molecule, molecule projections, defocus spread, methylamine tungstate Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biophysical Society, Blackwell Science Ltd, Cell Press, Walter Hoppe, Macromolecular Assemblies Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
6
books
cite this book:
See all 6 books citing this book
- RNA - Ligand Interactions, Part A (Methods in Enzymology, Volume 317) by John N. Abelson on page 289
- Progress in Nucleic Acid Research and Molecular Biology, Volume 59 by Kivie Moldave on page 207
- Electro Microscopy Methods and Protocols (Methods in Molecular Biology) by M. A. Nasser Hajibagheri on page 48
- Molecular Modeling and Simulation by Tamar Schlick in Back Matter
- Chromatin and Chromatin Remodeling Enzymes, Part B, Volume 376 (Methods in Enzymology) by Carl Wu on page 50
See all 6 books citing this book
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