Best answer is here: ftp://downloads.netgear.com/files/WNR1000_SM_WW_23Jan09.pdf
The short answer to your question is this. It doesn't matter what kind of computer you are using to set it up, nor does it matter which operating system you are using. You will use a web browser to do the setup, as described in the setup manual above. The only thing I would caution out about is that you use a standard browser. Explorer or Firefox or Chrome are all good.
It should be simple. The utility helps you set it up for users that don't know how to navigate the router directly. I would not recommend to enable the guest account /login. That part can be confusing and difficult for guest users.