EDIT: Ended up buying this myself, so here's the answer: yes, given you use a joystick/controller software to map to mouse/keyboard movements. I'm using JoyToKey, but apparently Control MK also works. Here's the instructions and mapping for JoyToKey: http://www.hellgateguru.com/forum/showthr
EDIT#2: Actually the software xPadder is more versatile and easier to set up. give it a go instead.