I have not been using this product twice-a-day like it recommends on the label, but once per day has been great to me. Previously, I used soap and I would get breakouts occasionally. Then I tried Neutrogena for Men ($7 for 4 oz!), which made me break out badly and I stopped using it after a week and went back to soap. Then I went on Amazon and read reviews about pHisoderm, which I either never saw or never paid attention to at stores. I decided to give it a try since 4 bottles cost almost as much as that one Neutrogena bottle and what a great purchase. It has not only prevented breakouts, but it is also clearing out the little white heads that were on my forehead (I have oily skin) and blemishes. It's not a harsh product either and feels rather mild. I can see why they have been around for 40 years.