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The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine Hardcover – September 7, 2010
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Do you have gene variants associated with Alzheimer’s or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions—and many more—by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure. Indeed, many experts are advocating that all newborns have a complete genome analysis done so that preventive measures and preemptive medicine can begin early in life.
How has this astonishing achievement been accomplished? And what will it mean for our lives? To research the story of this unfolding revolution, critically acclaimed science writer Kevin Davies has spent the past few years traveling to the leading centers and interviewing the entrepreneurs and pioneers in the race to achieve the $1,000 genome. He vividly brings to life the extraordinary drama of this grand scientific achievement, revealing the masterful ingenuity that has transformed the process of decoding DNA and delivering the information it possesses to the public at large.
Davies also profiles the future of genomic medicine and thoughtfully explores the many pressing issues raised by the tidal wave of personal genetic information. Will your privacy be protected? Will you be pressured, by insurance companies or by your employer, to get your genome sequenced? What psychological toll might there be to discovering you are at risk for certain diseases like Alzheimer’s? And will the government or the medical establishment come between you and your genome?
One thing that is not in question is that we are moving swiftly into the personalized medicine era, and The $1,000 Genome is an essential guide to this brave new future.
- Print length352 pages
- LanguageEnglish
- PublisherFree Press
- Publication dateSeptember 7, 2010
- Dimensions6 x 1.1 x 9 inches
- ISBN-101416569596
- ISBN-13978-1416569596
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Editorial Reviews
Review
--The Spittoon (spittoon.23andme.com)
Kevin Davies' The $1,000 Genome deserves to be widely read... It presents a careful and I think entertaining view of the past and possible future of personal genomics. --Keith Robison -- "Omics! Omics" (omicsomics.blogspot.com)
In this informative and accessible work of scientific journalism, Englishman Kevin Davies predicts that personalized genome sequencing will soon become so affordable that it will revolutionize medicine. --Winnipeg Free Press
From the Author
The second was my first conversation with the co-founder of 23andMe, a pioneering consumer genomics company offering tantalizing personal genomic information at an affordable price (less than $1,000) to the public at large. Since then, tens of thousands of people have sent saliva samples to various consumer genomics firms. In a handful of cases, some recounted in the book, the results are nothing short of life-changing, and possibly life-saving.
Since 2007, the cost of genome sequencing has plummeted at an astonishing rate. Today, anyone can get their genome sequenced for less than $20,000, and that price will inevitably drop to $1,000 in the coming years as new technologies arrive. Imagine getting a full genome scan as easily and routinely as an MRI -- and without the claustrophobia! Even better, imagine a Star Trek Tricorder device reading your complete genetic code in a matter of minutes! That's a very real possibility in the next few years.
The bigger question, however, is whether that is going to make a difference to the health of yourself and your family? Having access to your full genome isn't magically going to reveal whether you're going to develop diabetes, cancer or heart disease, but it is going to become a fundamental part of your medical record. Among the challenges ahead of us discussed in the book: Will our genome data be kept private? Will we be subject to insurance or employment discrimination if we have our DNA sequenced? What can my genome really tell me about my disease risk? Who is going to explain that analysis to me -- not to mention my family doctor?
My intention in The $1,000 Genome isn't necessarily to answer all those questions, but to raise awareness of the rapidly approaching era of genome sequencing and increasingly personalized medicine. The technology will be with us very soon: the medical, legal and health care professions need to start preparing now. As should you!
See: youtube.com/watch?v=XXe74r7eYQw&feature=player_embedd
About the Author
Product details
- Publisher : Free Press; 1st edition (September 7, 2010)
- Language : English
- Hardcover : 352 pages
- ISBN-10 : 1416569596
- ISBN-13 : 978-1416569596
- Item Weight : 1.15 pounds
- Dimensions : 6 x 1.1 x 9 inches
- Best Sellers Rank: #1,203,743 in Books (See Top 100 in Books)
- #972 in Genetics (Books)
- #5,069 in Biology (Books)
- #126,518 in Health, Fitness & Dieting (Books)
- Customer Reviews:
About the author

Kevin Davies is a British science journalist and editor. He is currently the executive editor of The CRISPR Journal, based in New York. Kevin studied at Oxford University and moved to the U.S. in 1987 after earning his PhD in genetics. He is the founding editor of the journal Nature Genetics and Bio-IT World magazine, former editor-in-chief of Cell Press, and the first publisher of C&EN, the weekly magazine of the American Chemical Society.
"EDITING HUMANITY" is Kevin's fourth book, and first for Pegasus Books. He published "The $1,000 Genome" in 2010 and "Cracking the Genome," about the race for the Human Genome Project, in 2000. His first book, "Breakthrough," co-authored with the late Michael White, was about the race to identify the "breast cancer gene". That resulted in Kevin serving as technical consultant for the 2013 movie Decoding Annie Parker, starring Helen Hunt, Samantha Morton and Aaron Paul. He's also a co-author with Jim Watson and Andrew Berry of "DNA: The story of the Genetic Revolution" (Knopf, 2017).
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Top reviews from the United States
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Don't read this looking to find more about sequencing technology or uses. The book has about the technical content of a USA today article.
Here's the full description of the rise of Curagen: "He invented a patented method for studying gene expression by looking up activity patterns in a database, which he dubbed "GeneCalling". Two sentences later the company "had raised some $600 million" and it's "estimated that his major investors each made $100 million". They made money by raising money? Or does the paragraph intend to say that Curagen was *sold* for $600M? Somebody paid $600M for a method of looking up patterns in a database? Really?
This is the book for you if you want descriptions of colorful characters and what they say about each other, reporting on parties and publicity events, anecdotes about genetic defects in the relatives of people involved in the companies, ethical issues in consumer sequencing, and other such human interest flotsam.
Not for you if you'd like to learn what the technology is and what can be done with it.
It is not for people who already understand the science.
I work in the sector but in the finance department and it gave me a much better idea of what our science folks are up to. I am delighted with it as that is what I was looking for.
This book heightened my interest in biomedicine and gave me several new topics to which I will return.
I commend it to those with intellectual curiousity and little knowledge of this field.
Also the ancestral reports are incorrect, they need to look at all the chromosomes not just XX and XY. A lot of historical data is missing.
I am a graduate student currently working in the area of genomics and a bit too young to appreciate the nuanced perspective surrounding sequencing technologies. The $1000 Genome was a great primer and a quick update on the people and institutions that ushered in this exciting new age in medicine. This book does a good job in bringing historical context to important genetic discoveries, by people including Mary Claire King and BRCA1 in 1990 and Jeffery Friedmann with the Leptin gene in 1994, without going overboard. The discussion on the biotech companies and "recreational genomics" were particularly interesting --> how google.com help launch 23andme and 454 Life Science sequenced Jim Watson in 2007. Overall, I think this book would resonate with people who are generally interested in the potential of DNA technologies to inform medicine that do not want to dredge through 20 years of commentary. It is not overly technical and it is written from a journalistic perspective that has bits of humor and interesting factoids spread throughout.
As other reviewer's have mentioned, the vast majority of what makes this book exciting is based on companies that are still in business and technologies that are still innovative . . if you are interested in reading this book, you would be wise to read it sooner rather than later!
Top reviews from other countries
I've said what I want to so this sentence is to make you happy with 20 words!




