Qty:1
Bayer Advantage II, Large... has been added to your Cart

Other Sellers on Amazon
Add to Cart
$39.99
+ Free Shipping
Sold by: Luty's Pet Shoppe
Add to Cart
$40.88
+ Free Shipping
Sold by: PETSporium
Add to Cart
$43.99
& FREE Shipping on eligible orders. Details
Sold by: Famous Shamus Pet Supplies

Bayer Advantage II Topical Flea Treatment Dogs

4.2 out of 5 stars 1,958 customer reviews
| 58 answered questions

List Price: $54.54
Price: $38.69 & FREE Shipping on orders over $49. Details
You Save: $15.85 (29%)
In Stock.
Ships from and sold by Amazon.com. Gift-wrap available.
21 to 55-Pound
4-Month
  • Kills adult fleas, eggs and larvae
  • Remains effective even after swimming or shampooing
  • One treatment prevents further flea infestation for at least four weeks
  • Packaging may vary
14 new from $38.69

Salvo Flea and Tick Collar
$38.69 & FREE Shipping on orders over $49. Details In Stock. Ships from and sold by Amazon.com. Gift-wrap available.

Frequently Bought Together

  • Bayer Advantage II, Large Dogs, 21 to 55-Pound, 4-Month
  • +
  • Bayer Advantage II for Large Cats Over 9 lbs, 6 Pack
Total price: $91.68
Buy the selected items together


Product Description

Size: 21 to 55-Pound | Style: 4-Month

Biting fleas are more than just a nuisance for your dog. Left unchecked, they can cause serious disorders such as flea allergy dermatitis, secondary skin infections, tapeworms, and even anemia. This topical flea treatment lets you stop fleas before they become a problem. Used just once a month, it begins working in minutes, killing 98 to 100 percent of the fleas on dogs within 12 hours and 99 percent of flea larvae and eggs within 20 minutes. The dead fleas can't lay eggs, and the dead larvae and eggs can't hatch, breaking the flea's life cycle and halting the infestation in its tracks. Any new fleas your dog then encounters are killed within two hours, preventing re-infestation for as long as four weeks. In fact, Advantage II is so effective at breaking the flea's life cycle there's no need to treat your dog's environment. Applied before the start of flea season, it helps keep your dog from becoming infested in the first place. Used year-round, it prevents fleas from over-wintering in your home to feast on your dog next season. Gentle enough for puppies as young as seven weeks, Advantage II is water-resistant and continues to work while your dog swims or is bathed. The package includes four pre-measured doses for dogs 21-55 pounds in easy-to-use applicator tubes. For safety, keep out of the reach of children, and read all warnings and instructions carefully.

Product Details

Size: 21 to 55-Pound | Style: 4-Month
  • Product Dimensions: 6.5 x 1 x 4.2 inches ; 1.6 ounces
  • Shipping Weight: 1.6 ounces (View shipping rates and policies)
  • ASIN: B004QRFJA4
  • Item model number: 4461758
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (1,958 customer reviews)
  • Amazon Best Sellers Rank: #3,277 in Pet Supplies (See Top 100 in Pet Supplies)
  • Manufacturer’s warranty can be requested from customer service. Click here to make a request to customer service.

Customer Questions & Answers

Customer Reviews

Top Customer Reviews

Style Name: 6-MonthSize: 55-Pound Verified Purchase
I live in the American South, and my vets agree that Advantage works better than Frontline or any generic products. To get the most value for your money, I recommend buying the dosage for extra-large dogs and splitting it among smaller dogs. Save a small jar such as for pimentos or olives. Ask your pharmacist for a plastic dosing syringe (the kind for giving kids liquid medicine); they will likely give you one. I've attached a sample picture of the type of syringe you need. You need one without a needle that holds the amount of ML you will be using, based on the below guidelines.

Take off your dog's collar to ensure it doesn't slide down onto where you will be putting the Advantage. Open a package of Advantage and pour it into the jar. Pull into the syringe the right amount for your dog's weight:

0.4ml = 0-10#
0.8ml = 11-20#
1.2ml = 21-30#
1.6ml = 31-40#
2.0ml = 41-50#
2.4ml = 51-60#
2.8ml = 61-70#
3.2ml = 71-80#

You will put part of the Advantage on the dog's neck, and part of it in a few places down his back. Use your fingers to part the dog's hair on the back of his neck. (See package instructions on where to place the treatment.) Slowly depress the plunger onto the skin, NOT on top of the hair. Otherwise, it will drip off of the hair. Do several more spots down the dog's spine.

Immediately give treats to keep them from shaking their heads around. I learned the hard way that, if your dog vigorously shakes, this product can take the paint off cabinets and the varnish off stainless steel!! I do the treatment outside and leave the dogs outside for an hour or so.

Buying the largest size of Advantage and dosing several dogs with it can save a lot of money in the long run.
Read more ›
1 Comment 185 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Style Name: 4-MonthSize: 55-Pound Verified Purchase
The drug in Advantage II for Dogs and Advantage II for Cats is exactly the same drugs (Imidacloprid and Pyriproxyfen) at the exact same concentrations.
If you buy this "Large Dog" package, you get four 4ml tubes. If you then empty those into a vial or vials, you can use a syringe (without needle) to apply the right dosage to your dogs AND cats. In fact, if your cats are under 10 pounds, you can get 10 cat doses out of each of these vials. That's a real bargain!

I am a former Vet Tech and can assure you I have been doing this for years (with Advantage first, and now Advantage II) with ZERO problems.

Use the following chart and you will be fine.
Cats up to 9 pounds - 0.4ml
Cats 10+ pounds - 0.8ml
Dogs 3-10 pounds - 0.4ml
Dogs 11-20 pounds - 1.0ml
Dogs 21-55 pounds - 2.5ml
Dogs 55+ pounds - 4.0ml
180 Comments 1,177 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Style Name: 4-MonthSize: 21 to 55-Pound Verified Purchase
I've been happily using these types of flea medications for 10 years. BUT, I'd given up over the last two years on Advantage and Frontline. They both seemed to have NO EFFECT. Maybe the fleas in my area had become immune? I tried the others from the local big box store, they didn't work either.

I thought I'd try this "advantage II", maybe Bayer had changed the forumulation?

To my surprise - it worked great! I have two 60 lb dogs (shepherd and golden retriever) who were miserable this summer, as was I, because neither my Shepherd nor I enjoyed weekly baths to try to control the fleas.

This stuff is magic.

No more fleas on my pets or in my carpets.
Comment 152 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Style Name: 6-MonthSize: 55-Pound Verified Purchase
ALL PET OWNERS NEED TO BE MADE AWARE OF A SERIOUS SHIPPING ORDER ERROR which has occurred twice ------- ADVANTAGE II is being replaced/substituted with ADVANTIX II which is quite TOXIC TO CATS AND COULD PROVE LIFE THREATENING!!!!!! This is for ORDERS PLACED **** FULFILLED VIA AMAZON.*******

<<This is not a review of the product (I had to give a rating for this to post).>>
This is an ANNOUNCEMENT TO HOPEFULLY PREVENT POSSIBLE TRAGEDY. We ordered ADVANTAGE II for both of our 60+ pound dogs as well as our cats shortly BEFORE CHRISTMAS due to the excessively warm weather which has caused the flea population to explode. We measure out the proper dosage using a no needle syringe to apply this product, something we have been doing for several years. The package arrived with ADVANTIX II instead. After verifying that we had not mistakenly ordered the wrong product we started the return process thinking this was a one of/once in awhile mistake. THE REPLACEMENT PRODUCT ARRIVED, much to our shock and dismay WE RECEIVED ADVANTIX II. .... AGAIN! Having this serious error occur twice made us realize that this could be happening to other unsuspecting pet owners. PLEASE LOOK AT AND VERIFY YOUR FLEA MEDICATION BEFORE APPLYING ------ ADVANTAGE II GOOD FOR BOTH DOGS AND CATS (use proper dosage amounts) ------- ADVANTIX II IS FOR DOGS ONLY! !

UPDATE 1/04/2016 ----- We went ahead and purchased the Advantage II from a local pet store and will be returning the incorrectly mailed Avantix II. We felt there was no sense exchanging it for a 3rd try at getting this order right.
4 Comments 27 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Style Name: 4-MonthSize: 11 to 20-Pound
I have used Frontline for years and it always took and week to kick in and only lasted for about 2 weeks and my dog started scratching like crazy again. So I switched to this and it worked in just one day and lasts for a full month!!! My dog has never been happier!!
Comment 31 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse

Most Recent Customer Reviews

Set up an Amazon Giveaway

Bayer Advantage II, Large Dogs, 21 to 55-Pound, 4-Month
Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers. Learn more about Amazon Giveaway
This item: Bayer Advantage II, Large Dogs, 21 to 55-Pound, 4-Month