- Hardcover: 438 pages
- Publisher: Wiley; 1 edition (June 26, 2012)
- Language: English
- ISBN-10: 0470584920
- ISBN-13: 978-0470584927
- Product Dimensions: 6.2 x 1.2 x 9.3 inches
- Shipping Weight: 1.8 pounds (View shipping rates and policies)
- Average Customer Review: 92 customer reviews
- Amazon Best Sellers Rank: #66,249 in Books (See Top 100 in Books)
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Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer 1st Edition
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“This book offers a refreshing perspective for anyonewanting to get a comprehensive background on the newer emerginginterest in targeting cancer metabolism for therapy.” (Doody’s, 11 January 2013)
“For the first time, an entire issue is being devoted to areview article based on a recent medical book. This is a departurefrom our usual format, but I think you will agree that this topicwarrants the detailed treatment we have given it . . .This bookshould be required reading for all scientifically literate peoplewho are involved in the cancer problem.” (Advancesin Cancer Treatment, 1 October 2012)
From the Back Cover
A groundbreaking new approach to understanding, preventing,and treating cancer
Supported by evidence from more than 1,000 scientific andclinical studies, this groundbreaking book demonstrates that canceris a metabolic disease and, more importantly, that it can be moreeffectively managed and prevented when it is recognized as such.Moreover, the book provides detailed evidence that the traditionalview of cancer as a genetic disease has been largely responsiblefor the failure to develop effective therapies and preventivestrategies.
Cancer as a Metabolic Disease reevaluates the origins ofcancer based on the latest research findings as well as severaldecades of studies exploring the defects in tumor cell energymetabolism. Author Thomas Seyfried is a biochemical geneticist whohas been investigating the lipid biochemistry of cancer for thirtyyears. In this book, he carefully establishes why approachingcancer as a metabolic disease leads to better understanding andmanagement of all aspects of the disease, including inflammation,vascularization, cell death, drug resistance, and genomicinstability. In addition, the book explores:
- Origin of metastasis
- New treatment strategies that target tumor cell energymetabolism, including the ketogenic diet
- More effective prevention strategies in light of the metabolicorigin of cancer
- Case studies and perspectives from the point of view ofphysicians, patients, and caregivers
Throughout the book, tables, figures, and graphs summarize keyinformation and clarify complex concepts. In addition, the renownedcancer biochemist Peter Pedersen from Johns Hopkins Medical Schoolalso provides a historical perspective on the importance of theinformation presented in his foreward to the book.
Cancer as a Metabolic Disease is essential reading forall cancer researchers and clinicians as well as public healthprofessionals. By treating cancer as a metabolic disease, the booksets readers on a new, more promising path to understanding theorigins of cancer and developing new, more effective strategies totreat and prevent it.
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Stephen B. Strum, MD, FACP
Medical Oncologist, Member of ASCO (American Society of Clinical Oncology) since 1975
According to Otto Warburg's theory of cancer, mitochondrial dysfunction is the origin of cancer. Dr. Seyfried has amassed extensive evidence to support Warburg's theory and advances the idea that cancer arises from defects in energy metabolism (mitochondrial dysfunction), and that this metabolic dysfunction triggers genomic instability, activates oncogenes and inactivating tumor suppressor genes. The author does an incredible job at convincing the reader that healthy mitochondria are the ultimate tumor suppressor.
It's clear that the strategy to treat cancer as a genetic disease is not working following metastasis of solid primary tumors, but this fuels the pharmaceutical industry. Enormous amounts of money are spent on large cancer genome projects, but this has not advanced our understanding or treatment of cancer as expected. The cancer genome project has actually created more confusion amongst cancer researchers, and this is very clear if one reads the literature. On the other hand, when cancer is viewed as a metabolic disease the strategies to treat and prevent cancer become incredibly simplistic and economical. For example, animals studies, case reports and anecdotal evidence demonstrate that metabolic therapies that lower blood glucose and elevate ketones will quickly reduce tumor growth, extend lifespan and in some cases cause complete remission. This strategy is effective because cancer cells are fueled by glucose and lack the ability to derive energy from ketones due to mitochondrial defects. Metabolic therapies exploit the mitochondrial defects associated with cancer by targeting glucose metabolism, reducing insulin and elevating ketones. These therapies are simple and include "therapeutic fasting", calorie restricted ketogenic diets and relatively cheap and safe drugs that target glycolysis, insulin and other cancer-specific metabolic pathways. The information in this book is valuable to patients and supported by extensive references. This book is technical (in parts), but the author has the ability to describe complicated processes with elegant simplicity.
I read this book immediately after reading "The Secret History of the War on Cancer" and "The Emperor of All Maladies". These are excellent books, but I found Dr. Seyfried's book to be more informative and empowering because it gives the reader clear evidence for the cause of cancer and highly effective strategies to prevent and treat the disease.
I would recommend this book to all cancer researchers, oncologists and layman interested in understanding the origin, management and treatment of cancer as a metabolic disease. This book will also be an extremely valuable resource for patients diagnosed with cancer.
Dominic D'Agostino, PhD, University of South Florida
There is no question that I distrust the MD who is trained to regurgitate and is prevented from pushing the frontiers of knowledge. We all need more PhDs to increase our understandings and to offer competing points of view to stimulate further investigation. Such a competing point of view exists in all science other than that offered by the medical industry which has consistently promoted conformance, not pursuit of knowledge. Just read Gary Taubes book, Good Calories, Bad Calories to appreciate this point of view.
Seyfried does not pretend to know it all nor know the answers. what he does is provide the experimental results he and others have generated and asks you to think for yourself (which the MDs and their practices discourage).
My understanding of his thesis is that science, as of now, has no idea how cancer forms. What we do know is that many cancers are dependent upon glucose as a fuel and hence treatment which deprives cancer cells of glucose might tend to stress cancer cells and make them less destructive. Seyfried also differentiates cancer in tumor form from cancer in the form of metastasis. In both cases he contends that the mitachondria within the cells are damaged (a contentious point that he directly addresses) but in the metastatic form the behavior is so similar to macrophage behavior that we might consider treating the metastatic cancer as if it were macrophages. By starving the macrophage from its fuel (which is not glucose but glutamine) requires an approach other than diet(which potentially can impact tumors). He offers an approach to the MD world that depends on a well established drug that is relatively harmless compared to the approaches that the MD world currently promotes.
This book was written for doctors to encourage them to open their minds. You, as a lay person, can read this book if you are willing to keep a reference handy (I use keep the internet within an arm's length). Actually you can read it without a reference, but its value to you will increase at least 2 orders of magnitude if you are willing to learn medical terminology. If you or your loved ones have cancer, that burden is miniscule.
This book is one of several must haves. Taubes, Freeman,Volek, Phinney, D'Augustino all are willing to think and add to our understanding of how the body works (vs proclaiming how the body works without the hard science behind the proclamations.
Without question, Thomas Seyfried joins the above list as a scientist who is truly bent on increasing our understanding of how the body works, vs promoting cancer models that have not reduced cancer deaths.
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