- Hardcover: 438 pages
- Publisher: Wiley; 1 edition (June 26, 2012)
- Language: English
- ISBN-10: 0470584920
- ISBN-13: 978-0470584927
- Product Dimensions: 6.2 x 1.2 x 9.3 inches
- Shipping Weight: 1.8 pounds (View shipping rates and policies)
- Average Customer Review: 90 customer reviews
- Amazon Best Sellers Rank: #77,313 in Books (See Top 100 in Books)
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Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer 1st Edition
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“This book offers a refreshing perspective for anyone wanting to get a comprehensive background on the newer emerging interest in targeting cancer metabolism for therapy.” (Doody’s, 11 January 2013)
“For the first time, an entire issue is being devoted to a review article based on a recent medical book. This is a departure from our usual format, but I think you will agree that this topic warrants the detailed treatment we have given it . . .This book should be required reading for all scientifically literate people who are involved in the cancer problem.” (Advances in Cancer Treatment, 1 October 2012)
From the Back Cover
A groundbreaking new approach to understanding, preventing, and treating cancer
Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.
Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores:
- Origin of metastasis
- New treatment strategies that target tumor cell energy metabolism, including the ketogenic diet
- More effective prevention strategies in light of the metabolic origin of cancer
- Case studies and perspectives from the point of view of physicians, patients, and caregivers
Throughout the book, tables, figures, and graphs summarize key information and clarify complex concepts. In addition, the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.
Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease, the book sets readers on a new, more promising path to understanding the origins of cancer and developing new, more effective strategies to treat and prevent it.
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Top customer reviews
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Stephen B. Strum, MD, FACP
Medical Oncologist, Member of ASCO (American Society of Clinical Oncology) since 1975
According to Otto Warburg's theory of cancer, mitochondrial dysfunction is the origin of cancer. Dr. Seyfried has amassed extensive evidence to support Warburg's theory and advances the idea that cancer arises from defects in energy metabolism (mitochondrial dysfunction), and that this metabolic dysfunction triggers genomic instability, activates oncogenes and inactivating tumor suppressor genes. The author does an incredible job at convincing the reader that healthy mitochondria are the ultimate tumor suppressor.
It's clear that the strategy to treat cancer as a genetic disease is not working following metastasis of solid primary tumors, but this fuels the pharmaceutical industry. Enormous amounts of money are spent on large cancer genome projects, but this has not advanced our understanding or treatment of cancer as expected. The cancer genome project has actually created more confusion amongst cancer researchers, and this is very clear if one reads the literature. On the other hand, when cancer is viewed as a metabolic disease the strategies to treat and prevent cancer become incredibly simplistic and economical. For example, animals studies, case reports and anecdotal evidence demonstrate that metabolic therapies that lower blood glucose and elevate ketones will quickly reduce tumor growth, extend lifespan and in some cases cause complete remission. This strategy is effective because cancer cells are fueled by glucose and lack the ability to derive energy from ketones due to mitochondrial defects. Metabolic therapies exploit the mitochondrial defects associated with cancer by targeting glucose metabolism, reducing insulin and elevating ketones. These therapies are simple and include "therapeutic fasting", calorie restricted ketogenic diets and relatively cheap and safe drugs that target glycolysis, insulin and other cancer-specific metabolic pathways. The information in this book is valuable to patients and supported by extensive references. This book is technical (in parts), but the author has the ability to describe complicated processes with elegant simplicity.
I read this book immediately after reading "The Secret History of the War on Cancer" and "The Emperor of All Maladies". These are excellent books, but I found Dr. Seyfried's book to be more informative and empowering because it gives the reader clear evidence for the cause of cancer and highly effective strategies to prevent and treat the disease.
I would recommend this book to all cancer researchers, oncologists and layman interested in understanding the origin, management and treatment of cancer as a metabolic disease. This book will also be an extremely valuable resource for patients diagnosed with cancer.
Dominic D'Agostino, PhD, University of South Florida