- Hardcover: 438 pages
- Publisher: Wiley; 1 edition (June 26, 2012)
- Language: English
- ISBN-10: 0470584920
- ISBN-13: 978-0470584927
- Product Dimensions: 6.2 x 1.2 x 9.3 inches
- Shipping Weight: 1.8 pounds (View shipping rates and policies)
- Average Customer Review: 4.3 out of 5 stars See all reviews (82 customer reviews)
- Amazon Best Sellers Rank: #187,536 in Books (See Top 100 in Books)
Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required.
To get the free app, enter your mobile phone number.
Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer 1st Edition
Use the Amazon App to scan ISBNs and compare prices.
Featured resources for clinical rotations
Explore these titles for clinical rotations. Learn more
Frequently bought together
Customers who bought this item also bought
“This book offers a refreshing perspective for anyone wanting to get a comprehensive background on the newer emerging interest in targeting cancer metabolism for therapy.” (Doody’s, 11 January 2013)
“For the first time, an entire issue is being devoted to a review article based on a recent medical book. This is a departure from our usual format, but I think you will agree that this topic warrants the detailed treatment we have given it . . .This book should be required reading for all scientifically literate people who are involved in the cancer problem.” (Advances in Cancer Treatment, 1 October 2012)
From the Back Cover
A groundbreaking new approach to understanding, preventing, and treating cancer
Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.
Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores:
- Origin of metastasis
- New treatment strategies that target tumor cell energy metabolism, including the ketogenic diet
- More effective prevention strategies in light of the metabolic origin of cancer
- Case studies and perspectives from the point of view of physicians, patients, and caregivers
Throughout the book, tables, figures, and graphs summarize key information and clarify complex concepts. In addition, the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.
Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease, the book sets readers on a new, more promising path to understanding the origins of cancer and developing new, more effective strategies to treat and prevent it.
Browse award-winning titles. See more
If you are a seller for this product, would you like to suggest updates through seller support?
Top Customer Reviews
Stephen B. Strum, MD, FACP
Medical Oncologist, Member of ASCO (American Society of Clinical Oncology) since 1975
According to Otto Warburg's theory of cancer, mitochondrial dysfunction is the origin of cancer. Dr. Seyfried has amassed extensive evidence to support Warburg's theory and advances the idea that cancer arises from defects in energy metabolism (mitochondrial dysfunction), and that this metabolic dysfunction triggers genomic instability, activates oncogenes and inactivating tumor suppressor genes. The author does an incredible job at convincing the reader that healthy mitochondria are the ultimate tumor suppressor.
It's clear that the strategy to treat cancer as a genetic disease is not working following metastasis of solid primary tumors, but this fuels the pharmaceutical industry. Enormous amounts of money are spent on large cancer genome projects, but this has not advanced our understanding or treatment of cancer as expected. The cancer genome project has actually created more confusion amongst cancer researchers, and this is very clear if one reads the literature. On the other hand, when cancer is viewed as a metabolic disease the strategies to treat and prevent cancer become incredibly simplistic and economical. For example, animals studies, case reports and anecdotal evidence demonstrate that metabolic therapies that lower blood glucose and elevate ketones will quickly reduce tumor growth, extend lifespan and in some cases cause complete remission. This strategy is effective because cancer cells are fueled by glucose and lack the ability to derive energy from ketones due to mitochondrial defects. Metabolic therapies exploit the mitochondrial defects associated with cancer by targeting glucose metabolism, reducing insulin and elevating ketones. These therapies are simple and include "therapeutic fasting", calorie restricted ketogenic diets and relatively cheap and safe drugs that target glycolysis, insulin and other cancer-specific metabolic pathways. The information in this book is valuable to patients and supported by extensive references. This book is technical (in parts), but the author has the ability to describe complicated processes with elegant simplicity.
I read this book immediately after reading "The Secret History of the War on Cancer" and "The Emperor of All Maladies". These are excellent books, but I found Dr. Seyfried's book to be more informative and empowering because it gives the reader clear evidence for the cause of cancer and highly effective strategies to prevent and treat the disease.
I would recommend this book to all cancer researchers, oncologists and layman interested in understanding the origin, management and treatment of cancer as a metabolic disease. This book will also be an extremely valuable resource for patients diagnosed with cancer.
Dominic D'Agostino, PhD, University of South Florida
Seyfried enters this field not only with some new ideas about causes, but some most excellent new ideas about therapeutics. And most surprising, he does it all in the context of a writing style that is both readable and even enjoyable. His recurring interjections with "Hello! Oncologists, are you listening?" seem, at the same time, out of place in an academic text and a welcome and needed shout at the conventional oncology world that has been oblivious to the evidence Seyfried amasses.
Seyfried's thesis might be summarized as, "It's the mitochondria, Stupid!" While the conventional oncology world has focused on a small percentage of characteristics that are unique to each type of cancer, Seyfried is calling attention to the set of changes that are common to all cancers, regardless of type. And central to those commonalities are specific alterations in mitochondrial function and the metabolic and genetic changes that flow from them.
Most importantly, Seyfried shows the obvious therapeutic interventions that are indicated by his thesis. The unfortunate point is that the therapies he is advocating are not likely to be embraced in the oncology world generally. For example, a very specific calorie-restricted diet for cancer patients is critical, and flies in the face of the common horrendous nutritional advice given to cancer patients, which is to eat lots of calories - in any form - just to maintain weight. Seyfried's nutritional approach to cancer control requires a great deal of patient *and physician* education about nutrition.
This is just one aspect of treatment addressed in the book. Overall, I found it to be well-written, well-substantiated, and clinically relevant. In the oncology world, that is an exceedingly rare Trifecta. I recommend this text for every health care practitioner involved in the treatment of cancer, and for cancer patients looking for a science-based understanding of their disease. Patients will end up with a list of critical questions to ask their oncologist, questions that will likely make those oncologists very uncomfortable.