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Cannabis: From Pariah to Prescription 1st Edition

4.0 out of 5 stars 1 customer review
ISBN-13: 978-0789023995
ISBN-10: 0789023997
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Editorial Reviews

Review

EDUCATIONAL AND PROVOCATIVE. . . . EXTREMELY TIMELY. . . . A compendium of clinical studies conducted by GW Pharmaceuticals -- Ken Mackie, MD, Professor or Anesthesiology, Adjunct Professor of Physiology & Biophysics, University of Washington School of Medicine, Seattle

IMPORTANT AND COMPREHENSIVE conclusions contained in this work are CRUCIAL TO ADVANCEMENT IN OUR KNOWLEDGE OF CANNABIS AS PRESCRIPTION MEDICINE -- Senator Pierre Claude Nolin, Conservative Party, Canada --This text refers to the Hardcover edition.

About the Author

Russo is a neurologist at Western Montana Clinic, Department of Neurosciences.
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Product Details

  • Paperback: 196 pages
  • Publisher: Routledge; 1 edition (March 11, 2004)
  • Language: English
  • ISBN-10: 0789023997
  • ISBN-13: 978-0789023995
  • Product Dimensions: 6 x 0.5 x 8.4 inches
  • Shipping Weight: 10.6 ounces (View shipping rates and policies)
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #890,880 in Books (See Top 100 in Books)

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Format: Hardcover
This book is a reprint of Journal of Cannabis Therapeutics, Volume 3, Numbers 3 and 4 2003.

It is mostly aimed at making widely available the results of the careful clinical trials of cannabinoid sprays(ie, solutions for spraying in the nose or mouth, not smoke or tablets) in humans done by GW Pharmaceuticals in the UK as a necessary preliminary to putting their groundbreaking products on the market. Russos three excellent articles at the beginning and end provide a contrast to the three very dry but necessary and precise clinical articles.

It is certain that there must be many disease states associated with the endogenous cannabinoids. Russo and GW are the first to to controlled clinical experiments on solutions of cannabidiol and THC together. As I pointed out in my own book on marijuana chemistry 30 years ago, this is critical as CBD is always present in natural marijuana and it modulates the effects of THC. Other researchers have never used them separate or together in a spray form. This is critical as both smoke and pill forms are nearly impossible to control and titrate and this has been a major barrier to medical use. In this way , GW Pharmaceuticals hopes to make a major impact on the medical use of cannabinoids and have entered them into the drug licensing process in many countries as treatments for multiple sclerosis and other problems.

An enormous amount of research is in process on synthetic, marijuana derived and endogenous cannabinoids. This is primarily due to the discovery of the endogenous anandamides and their receptors. There are thousands of compounds that can stimulate and inhibit the activity of CB1 and CB2 receptors and the list of potential therapeutic actions is nearly coextensive with human physiology, behavior and disease.
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