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The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens (Issues in Toxicology)
"This book will, therefore, make excellent and stimula ting reading for all toxicologists (from the student to the most senior toxicologist} in academia, industry and government as well as scienlists responsible for health risk assessment. It urges readers to accept scientifically based thresholds not only for non-genotoxic (epigenetic) carcinogens but also - and more importantly - for genotoxic carcinogens. It is highly recommended!" (Hans Marquardt, Hamburg, Germany Toxicology) --This text refers to an alternate Hardcover edition.
Although the cellular defence mechanisms are increasingly understood, the critical and rate limiting parameters and their dose-response to the insulting agent need to be evaluated. In this book the different cellular defence mechanisms and their regulation are described. Understanding the protective mechanisms by which the cell responds to a genotoxic impact to protect integrity of the genomes will permit the evaluation of whether the assumption of a threshold for genotoxic carcinogens at low dose exposure is justified. Besides its scientific value, this dispute is of regulatory importance since it may result in a scientifically defendable threshold concept for genotoxic carcinogens, will allow identification of a NOEL and by that to propose health based exposure limits - even for genotoxic carcinogens. --This text refers to an alternate Hardcover edition.
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