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David William Rasnick
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The Chromosomal Imbalance Theory of Cancer 1st Edition

by David Rasnick (Author)
5.0 5.0 out of 5 stars 4 ratings
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The book deals with the chromosomal imbalance (aneuploidy) theory of cancer. The book explains how gene mutations are not powerful enough to cause cancer, describes how cancer is initiated and why progression takes years to decades, and accounts for the global or macroscopic characteristics that readily identify cancer. In addition, it clarifies why cancer cells often become drug resistant even to drugs they were never exposed, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of cancer therapy and prevention. In short, it posits that the autocatalyzed progression of aneuploidy is carcinogenesis.
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  1. ISBN-10
    1578087376
  2. ISBN-13
    978-1578087372
  3. Edition
    1st
  4. Publication date
    January 6, 2012
  5. Language
    English
  6. Dimensions
    0.81 x 6.14 x 9.21 inches
  7. Print length
    360 pages
  8. See all details
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Editorial Reviews

About the Author

Rasnick, David

Product details

  • Publisher ‏ : ‎ CRC Press; 1st edition (January 6, 2012)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 360 pages
  • ISBN-10 ‏ : ‎ 1578087376
  • ISBN-13 ‏ : ‎ 978-1578087372
  • Item Weight ‏ : ‎ 1.32 pounds
  • Dimensions ‏ : ‎ 0.81 x 6.14 x 9.21 inches
  • Customer Reviews:
    5.0 5.0 out of 5 stars 4 ratings

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David William Rasnick

David William Rasnick

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Top reviews from the United States

  • CGBS
    5.0 out of 5 stars interesting and well-developed theory
    Reviewed in the United States on March 3, 2020
    Verified Purchase
    I enjoyed this book and incorporated this theory into my research. The mainstream is sometimes or perhaps often incorrect for various political reasons. Therefore, progress requires searching for logical and well-supported theories outside the mainstream. Other theories of cancer that I found to be well supported by clinical and basic research evidence are the enzymatic theory of cancer (John Beard/William Kelley) and catabolic/anabolic imbalance theory (Emanuel Revici).
    Regarding the book in question, I would like to see limitations of the theory discussed in more detail; also the singular emphasis on hyperthermia does not seem to be justified. Perhaps a combination of modalities, including hyperthermia, might have a higher success rate. The book "Fight Cancer" (charles spender) proposes over 20 interventions, which can be combined.
    One person found this helpful
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  • Cliente Amazon
    5.0 out of 5 stars perfect
    Reviewed in the United States on November 17, 2019
    Verified Purchase
    perfect book, quick arrival
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  • Tom Bethell
    5.0 out of 5 stars Aneuploidy and Cancer
    Reviewed in the United States on August 3, 2012
    David Rasnick's book, The Chromosomal Imbalance Theory of Cancer, is one of the most important books ever written on the genetics of cancer. But it is hurt by prolix and technical language. Rasnick also seems to think that mathematical equations will help our understanding.

    The book's importance is this. Rasnick shows that, for several decades and continuing today, the search for the mechanism that turns normal cells into cancer cells has mistakenly concentrated on GENE MUTATIONS. But no given gene mutation has ever been shown to cause the cellular transformation that is cancer. Nobel Prizes have been awarded to eminent researchers, including former NIH Director Harold Varmus and and UCSF Chancellor J. Michael Bishop, who identified a supposed viral oncogene in human cells. David Baltimore was similarly rewarded.

    But today as many as 250 mutated oncogenes and tumor suppressor genes are associated with cancer. Some say there are thousands of these cancer genes. But when the DNA of cancer cells is sequenced, very few of these mutated genes are found in more than one cancer cell. More and more cancer cells get sequenced, and more mutated genes are found to be "associated with" the cell. The problem is that association is raised to the level of causation. Bystanders are viewed as culprits.

    In short, the gene mutation theory of cancer is falling apart. It is what is called a "deteriorating paradigm." The Cancer Genome Atlas is swallowing up dollars without sense. In Nixon's War on Cancer, cancer is winning.

    Meanwhile, almost all tumor cells have the wrong complement of chromosomes. Instead of being "diploid," with one set of chromosomes coming from each parent, they have an aberrant number of chromosomes. They are not diploid but "aneuploid." Their ploidy is "not good" (which is what "aneu-" means.) Some cancer cells have as many as 80 chromosomes, instead of the appropriate 46.

    The well known Johns Hopkins cancer researcher Bert Vogelstein has said that at least 90 percent of all cancers consist of aneuploid cells. This percentage is far higher than that of any alleged cancer gene ever found. The vaunted breast cancer genes, BRCA-1 and BRCA-2, are NOT found to be mutated in over 90 percent of breast cancers.

    In fact, Rasnick reports, no diploid cancers have yet been identified in the literature.

    All of this information, and a great deal more, is to be found in Rasnick's book. He points out, for example, that "aneuploidy is currently not even mentioned in the cancer chapters of the leading textbooks of biology." He references those by Alberts et al (1994), Cairns (1978), Lewin (1997), Lodish et al. (2004) and Pierce (2005).

    Some of the best known carcinogens are NOT mutagenic. Nonetheless, Bruce Ames and others have claimed that "carcinogens are mutagens." Asbestos fibers, to give just one counterexample, are not.

    Siddhartha Mukherjee skirts aneuploidy in his widely praised (and well written) book The Emperor of All Maladies (2010). He comes close to noticing it when he points out that Theodor Boveri identified the chromosome problem as early as 1914. But Mukherjee is sidetracked by Peyton Rous and his Rous Sarcoma Virus, for which he won the Nobel in 1966. But the Rous virus turned out to be irrelevant to the cancer scourge, which still has us in its grip today.

    A simpler account than Rasnick's is needed. His index is poor and fully 70 pages are taken up with references to the academic literature. But for those who want to study the amazingly overlooked topic of aneuploidy and cancer, all the necessary information is in Rasnick's book. It deserves to be widely read and studied.

    Oh, and if you know of a reference in the academic literature to diploid cancer (not just "near-diploid"), please send it to David Rasnick, or append it here.

    Tom Bethell
    12 people found this helpful
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  • J. Baptiste
    5.0 out of 5 stars 5 stars
    Reviewed in the United States on April 28, 2018
    As another reviewer points out, it could have benefitted by being simpler, but overall it is highly readable. Oh, and revolutionary.
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