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Clinical Laboratory Hematology

4.1 out of 5 stars 30 customer reviews
ISBN-13: 978-0130199966
ISBN-10: 0130199966
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Editorial Reviews

From the Back Cover

Designed to meet the needs of both clinical laboratory technicians and clinical laboratory scientists, this comprehensive - yet easy to read - guide to hematology and hemostasis features cutting-edge technologies, high-quality photographs and micrographs, case studies, and convenient dual-level (basic and advanced) presentation of information. In each chapter, two levels of objectives and questions are presented, allowing content to fit specific course focus. Case studies and checkpoints in each chapter help apply and assess comprehension. Visual cross-referencing symbols throughout make finding information exceptionally easy.

  • Authoritative content from 24 contributors.
  • Running case studies throughout each chapter.
  • Checkpoints - questions, integrated throughout the chapter, with rationales provided.
  • High-resolution, full-color blood and bone marrow photographs throughout.
  • FREE CD-ROM contains a powerful database of images and self-assessment activities.
  • FREE integrated website - www.prenhall.com/mckenzie - compliments the text with study-guide style quiz questions and immediate tabulation of quiz results.
  • Detailed discussions of ethical issues and management issues.
  • The new technologies of molecular diagnostics, flow cytometry and cytogenetics presented here in a very easily understood manner.

Excerpt. © Reprinted by permission. All rights reserved.

Clinical Laboratory Hematology is a comprehensive, yet easy-to-read text of hematology and hemostasis written for students at all levels in clinical laboratory science programs, including clinical laboratory technicians, CLT (medical laboratory technicians, NET), and clinical laboratory scientists, CIS (medical technologists, MT). Other health professional students and practitioners may also benefit from this book, including pathology residents, physician assistants, and nurse practitioners. This text replaces Textbook of Hematology published by Lea & Febiger in 1988 and by Williams & Wilkins in 1996. However this text should be considered as a brand new publication because of its wide variety of changes and enhancements. Included among these changes are the following: we have assembled an extensive team of authoritative contributing authors to write chapters on specialized subjects within their respective fields of expertise; we have developed a striking design that will be conducive to today's visually oriented student; we have developed an exciting set of learning features that will help readers grasp the content more easily; we have developed a book-specific online study guide (wwwprenhall.com/mckenzie); and finally, we have packaged the text with a free student version of the Chronolab CD-ROM photomicrograph atlas.


Understanding hematologic/hemostatic diseases is dependent on a thorough knowledge and understanding of normal processes. Thus, the book begins with a section on normal hematopoiesis and progresses through anemias, nonmalignant and malignant leukocyte disorders. Hemostasis adheres to a similar format with normal hemostasis functions discussed first, followed by abnormalities in hemostasis.

The text is divided into sections and maybe studied by section or chapter sequence. This gives the instructor flexibility td fit the book to their specific course design. The first two sections cover an introduction to hematology and normal hematopoiesis. This includes a discussion of the cell morphology, cell cycle, and its regulation. The section includes a discussion on oncogenes emphasizing the concept that neoplasms are the result of mutations in normal genes that control cell proliferation and development. This concept is further discussed in the introduction to hematopoietic neoplasms. The third section, includes procedures that are routine and performed in most laboratories. These are included at the beginning of the book so the students will have basic laboratory test information as they proceed through the subsequent chapters on hematopoietic disorders which focus on laboratory diagnostic protocols.

The next sections cover the hematopoietic disorders and special laboratory procedures. The fourth section includes the anemias and begins with an introduction to anemia chapter. The fifth section is nonmalignant disorders of the leukocytes. The sixth section includes a discussion of special laboratory procedures that are useful in diagnosis and classification of hematopoietic neoplasms: flow cytometry, cytogenetics, and molecular diagnostics. This section may be studied before or after the seventh section on neoplastic hematopoietic disorders, depending on the reader's knowledge level of the neoplasms. If this is the reader's first exposure to the neoplasms, it may be better to cover section 7 before section 6. Alternatively, sections 6 and 7 can be integrated and studied together.

Section 8 is a study of body fluids. Body fluid analysis is often a function of the hematology laboratory, since analysis includes cell counts and review of cell morphology. As much of the analysis includes identification of cells and differentiation of malignant cells from reactive or normal cells, this section has many microphotographs.

Section 9 is a study of hemostasis. It begins with a study of normal hemostasis processes and proceeds to abnormalities that are associated with bleeding and thrombosis. Due to the high frequency of thrombotic disorders and the rapid discovery of mechanisms responsible for thrombosis, the laboratory's role in diagnosis of thrombotic disorders is expanding. Thus, an entire chapter is devoted to hypercoagulability (thrombophilia). This section also includes laboratory testing procedures for evaluation of hemostasis.

The last section includes special hematology procedures and quality assurance and safety in the laboratory. Automation in hematology and hemostasis will be supplemented on the Web page with extensive use of graphics to illustrate abnormal results and teach evaluation and interpretation of data.

The book incorporates ethical issues and management issues of test utilization and value, as well as critical testing pathways. This is the soft side of science but alerts the students to issues they will be facing in their work and communities. In many cases the laboratorian is the one who has the breadth of information needed to help make critical decisions involving the laboratory and its effective, efficient, ethical use.


This book has been designed for both CLT/MLT and CLS/MT students. Using only one textbook is beneficial and economical in laboratory science programs offering both levels. Use of the book is also helpful to programs that design articulated curricula. The CLS/MT program can be confident of the CLT's/MLT's knowledge level in hematology without doing an extensive CLT/MLT course analysis.

CLT/MLT instructors will need to communicate to their students what is expected of them. They may want their students to find the information in the text that allows them to satisfy the checklist, or they may assign particular sections to read. If not assigned specific sections, the CLT/MLT student may read more than expected which is certainly not a bad thing! The students and instructors should use the checklists to determine the material to be read.

The case study questions and checkpoints are not delineated by level. CLT/MLT students should try to answer as many of these as possible. CLT/MLT instructors should select appropriate chapters for their students. Some chapters, such as molecular techniques, cytogenetics, and flow cytometry may not be included in a CLT/MLT curriculum. Each program will need to assess what fits its particular curriculum.

CLS/MT students should be able to meet both Level I and Level II checklists in most cases, but of course there may be differences among expectations of programs. Therefore, instructors are encouraged to review the checklists to ensure their appropriateness for the course. Although all chapters are appropriate for the CLS/MT student, if the program has two levels of hematology courses, Level I and Level II, instructors may choose to use the book as for a CLT/MLT program in the first course and the remainder of the book in the second course.

In all cases the instructor should begin the course with sections 1 through 3. The remaining sections can be rearranged and used as the instructor desires. The "Background Basics" feature will help the instructor determine which concepts the student should have mastered before beginning a unit of study. This concept should help instructors customize their courses.


This text has a number of unique pedagogical features that will help the student assimilate, organize, and understand the information. Each chapter begins with a group of components intended to set the stage for the content to follow.

  • Background Basics alert students to material that should be learned or reviewed before starting the chapter. In most cases it refers readers to previous chapters to help them find the material if they want to review it.
  • Objectives are comprised of two levels of checklists: Level I for basic or essential information and Level II for more advanced information. These checklists were reviewed by clinical (medical) laboratory technician (CLT/MLT) educators who made recommendations that aimed the Level I checklists to their students. Clinical laboratory science/medical technologist (CLS/MT) educators may expect their students to meet both Level I and Level II checklists requirements.
  • Overview gives the reader an idea of the chapter content and organization.

Each chapter offers students a variety of opportunities to assess their knowledge and ability to apply it.

  • Case Study is a running case feature that first appears at the beginning of each chapter and focuses the student's attention on the subject matter that the chapter will cover. Throughout the chapter at appropriate places, additional information on the case may be given such as laboratory test results, and then questions are asked. The questions relate to the material presented in preceding sections. There is a case summary and answers to the questions in the appendix.
  • Checkpoints! are integrated throughout the chapter. These are questions that require the student to pause along the way to recall or apply information covered in preceding sections. The answers are in the appendix.
  • Summary concludes the text portion of each chapter in order to help the student bring all the material together.
  • Review Questions appear at the end of each chapter. There are two sets of questions, Level I and Level II, that are referenced to the Level I and Level II objectives checklists. Answers are in the appendix.

The page design features a number of enhancements intended to aid the learning process.

  • Bold symbols are used within the chapter text to help the student quickly cross-reference from the tables and figures to the text.
  • A oo symbol is also used when referring the student to another chapter.
  • Figures and tables are used liberally to help the student organize and conceptualize information. This is especially important to visual learners.
  • Algorithms (critical pathways, reflex testing pa...

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Product Details

  • Hardcover: 976 pages
  • Publisher: Prentice Hall (April 3, 2006)
  • Language: English
  • ISBN-10: 0130199966
  • ISBN-13: 978-0130199966
  • Product Dimensions: 8.8 x 1.6 x 10.9 inches
  • Shipping Weight: 4.8 pounds
  • Average Customer Review: 4.1 out of 5 stars  See all reviews (30 customer reviews)
  • Amazon Best Sellers Rank: #712,960 in Books (See Top 100 in Books)

Customer Reviews

Top Customer Reviews

Format: Hardcover
I was required to use this book for an Intro to Hematology class, and I must say this book is not reader-friendly at all. If you're a student that is new to the subject, this book will drive you nuts because of things not explaining clearly.

This book has lots of info when it make sense, but like I said this book is not reader-friendly. Many times while reading, I have to google or use older books for reference as to what the book was trying to say. Another annoying thing is when the book is telling you to use their website for reference. However, in order to use it -- you have to pay for it. (Ex: Figure A on web)

The book also uses lots of abbreviations -- so unless you can memorize all of the abbreviations at once -- you will turn the pages back to see what does it stand for again. This wouldn't be an issue if they use it regularly in the chapter, but you rarely see it, then about 10-15 pages later, the abbreviation shows up again. All this does is slow things down while reading.

These were just some of the problems I had with it while I was using this book. I would not recommend this book to anyone -- unless require -- because this book is too technical for students new to the subject.
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I loved this book. The photos helped immensely because I am taking a non-lab version of clinical hematology. The topics are easily searchable. You will use this book for other classes, so hold onto it! I've already used it for virology, hematology, and now I'm using it for microbiology. Even though the focus is on hematology, there are tie in topics for other subjects. This textbook is going on my shelf for graduate school.
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Format: Hardcover
So far I have only used it for hemostasis, but it offers great supplemental material to the lectures. However, I must say some of the diagrams get a little crazy when it comes to the factors, inhibitors, etc. and they could be cleaned up and made much much simpler! Overall a must for all MT, CLS, MLT students.
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My instructor for hematology was one of the authors of the text. This book is so comprehensive, it might feel overwhelming, but it is broken down for two types of learning levels, which helps a lot. Obviously, I felt like it really prepared me for exams since it was the author testing me, but I think it would be true for any student. If you know whats in this book, you know everything you need to. I'll be keeping this one for reference long after the course is over.
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I really hated to read this book for my hematology class just because it's the required one. I know there will be tons of info. in the book considering the book is written by phDs, but find it very hard to focus and understand due to the way they lay the information out. Basically they just spread out the info. in a repetitive, lengthy and sometimes ambiguous fashion. If the book is well edited, or they use more concise language, it will be much thinner and useful to grab the whole picture of the subject without leaving the details out. The credits only go to the nice pictures and descriptions.
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Format: Hardcover
While this text might serve as good reference material for the experienced lab technician, or whoever else might have need of it, it is *extremely* hostile for those new to the subject. Basic and advanced hematology topics are mixed together often without so much as even a paragraph break inbetween them. Lots of information and reference material is hidden behind an online 'firewall' of sorts, and more often than appropriate when it is in the text, it's contained in blocks of tables large enough to make memorization laughable.
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Format: Hardcover Verified Purchase
Like I have said previously, I have been ordering my books from Amazon.com because they are cheaper and more reliable. I ordered my book after my Clinical Hematology class had already started and was scared I be behind because I didn't have my book. Well I got my book on time from Amazon and went to class that night. Other students still didn't have their books due to the University not having them in stock yet. Well I had my book, while the others had to wait.

Order from Amazon.com, fast and reliable service.
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I purchased this book for an undergraduate Hematology course geared towards students who wish to pursue a career in clinical laboratory science. Overall, it was great with only a few minor issues.

The book is very thorough in each subject and often had significantly more information than what was needed for our undergraduate course. I imagine that it makes a great reference for those in the field. The most helpful aspect of this book is its heavy use of tables to summarize key points. Each chapter had two sets of learning objectives with the second set more challenging than the first and forces you to go back through the chapter and reread the material. Diagrams and captions for processes were very clear and much easier to comprehend than the text. The images of erythrocyte and leukocyte abnormalities were generally good, with few a bit on the fuzzy side.

The textbook's "Hematology Procedures" section (chapter 34) was lacking detailed procedures, which can only be accessed through the book's companion website (which you need a code for). Fortunately many of the procedures can be found elsewhere on the web, but it would be nicer if the publisher could have included them in the physical book. My second complaint is that the end-of-chapter questions are too easy when considering how detailed the book is. The case studies were too few and also too easy. My professor had to give us supplemental ones to prepare us for exams. I am assuming that more can be found online.

The textbook was overall good to use for the undergraduate class, and will be one of the few books that I will not sell back. I would give it 4.5/5 stars due to the minor flaws, but since Amazon doesn't allow for half-stars, I decided to round up and give it 5.
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