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Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating (Statistics for Biology and Health) Softcover reprint of hardcover 1st ed. 2009 Edition
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Despite advances in statistical approaches towards clinical outcome prediction, these innovations are insufficiently utilized in medical research. This book provides information on how modern statistical concepts and regression methods can be applied.
From the reviews:
"This book covers an important topic, because these prediction models are essential for individualizing diagnostic and treatment decision making. The topic is of increased importance as evidence-based medicine is increasingly implemented and as scientific and technological advances reveal new potential predictors of outcome. This book presents an approach for developing, validating, and updating prediction models.… [I]t provides ways to optimally utilize regression techniques to predict an outcome.… This book is written in a clear and accessible style.… [A]valuable resource for anyone interested in developing or applying a prediction model." (Todd A. Alonzo, American Journal of Epidemiology, 2009; Vol. 170, No. 4)
"Overall I think this is a well-written book, which will have a wide appeal. The idea of defining a strategy to deal with clinical prediction problems might be somewhat controversial, but considering the variable quality of statistical analyses that appear in the medical literature, I believe such an approach is desirable. The book appears to have struck a good balance between practical examples and descriptions of statistical techniques.... It is refreshing to see a practical book applying many modern regression techniques to real problems." (David Ohlssen, Journal of Biopharmaceutical Statistics, Issue 6, 2009)
"Dr Steyerberg … aims to provide an insight and also a practical illustration on how modern statistical concepts and regression methods can be applied in medical prediction outcomes. The book…will be of interest to those who work in medical cybernetics and indeed all cybernetics and systems researchers who are studying such medical problems and wish to apply statistical approaches and methodologies. It is worth examining the detailed contents list … and individual chapters may be of particular value to potential readers." (C. J. H. Mann, Kybernetes, Vol. 38 (6), 2009)
"The book … will be of interest to those who work in medical cybernetics and indeed all cybernetics and systems researchers who are studying such medical problems and wish to apply statistical approaches and methodologies." (C. J. H. Mann, Kybernetes, Vol. 38, No. 6, 2009)
“…and excellent practical guide for developing, assessing and updating clinical models both for disease prognosis and diagnosis. The book’s clinical focus in this era of evidence-based medicine is refreshing and serves as a much-needed addition to statistical modeling of clinical data. The book assumes a basic familiarity with modeling using generalized linear models, focusing instead on the real challenges facing applied biostatisticians and epidemiologists wanting to create useful models: dealing with a plethora of model choices, small sample sizes, many candidate predictors and missing data. This is an example-based book illuminating the vagaries of clinical data and offering sound practical advice on data exploration, model selection and data presentation. …The author uses simple simulations using a few reproducible R commands to motivate the use of imputation methods and shrinkage. These simple but illuminating illustrations are one of the highlights of the book and serve as excellent pedagogical tools for motivating good statistical thinking. …” (International Statistical Review 2009, 77, 2)
“This is an excellent text that should be read by anyone performing prediction modeling. … the text has three audiences epidemiologists and applied biostatisticians who want to develop or apply a prediction model health care professionals who want to judge a study that presents a prediction model and theoretical researchers … . I found the book very useful and I believe clinicians and policy makers will be similarly well served. … All are excellent summaries for readers and provide links to resources for further investigation.” (Chris Andrews, Technometrics, Vol. 53 (1), February, 2011)
From the Back Cover
This book provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but these innovations are insufficiently applied in medical research. Old-fashioned, data hungry methods are often used in data sets of limited size, validation of predictions is not done or done simplistically, and updating of previously developed models is not considered. A sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice.
Clinical prediction models presents a practical checklist with seven steps that need to be considered for development of a valid prediction model. These include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formats. The steps are illustrated with many small case-studies and R code, with data sets made available in the public domain. The book further focuses on generalizability of prediction models, including patterns of invalidity that may be encountered in new settings, approaches to updating of a model, and comparisons of centers after case-mix adjustment by a prediction model.
The text is primarily intended for clinical epidemiologists and biostatisticians. It can be used as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. It is beneficial if readers are familiar with common statistical models in medicine: linear regression, logistic regression, and Cox regression. The book is practical in nature. But it provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. In this era of evidence-based medicine, randomized clinical trials are the basis for assessment of treatment efficacy. Prediction models are key to individualizing diagnostic and treatment decision making.
Ewout Steyerberg (1967) is Professor of Medical Decision Making, in particular prognostic modeling, at Erasmus MC–University Medical Center Rotterdam, the Netherlands. His work on prediction models was stimulated by various research grants including a fellowship from the Royal Netherlands Academy of Arts and Sciences. He has published over 250 peer-reviewed articles in collaboration with many clinical researchers, both in methodological and medical journals.
- Publisher : Springer; Softcover reprint of hardcover 1st ed. 2009 edition (December 1, 2010)
- Language : English
- Paperback : 528 pages
- ISBN-10 : 1441926488
- ISBN-13 : 978-1441926487
- Item Weight : 1.77 pounds
- Dimensions : 6.1 x 1.19 x 9.25 inches
- Best Sellers Rank: #2,734,720 in Books (See Top 100 in Books)
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I found the part of evaluation and validation of prediction models very comprehensive and valuable.
Top reviews from other countries
I purchased this book for better understanding of calibration. Unfortunately, the writing style lacks in clarity and at too many places, parts of sentence are left implicit making me struggling to get at the authors intent. Paragraphs will be initiated abruptly with sentences like 'We define two groups of subjects .. ' where there are total four groups for example, and clearly the author has combined along either the row or column but with no reference to it. Issues like this are very frequent in this book, in nearly chapter or paragraph I open - short abrupt sentences and pronouns with missing references litter this book. I am giving it two-star (instead of one) because i am hoping that with the help of online articles, i can still benefit from the book. I hope the next edition works more on clarity
He draws heavily on Frank Harrell's book, Regression Modelling Strategies (I think he was a PhD student with him), but this book provides a more clinically-orientated guide to developing such models. While it assumes a certain level of technical ability, it starts quite easily and works up, which makes it easy to follow.
One of the nice things is that it spends some time explaining which tests and strategies to use when, and why they're important. As such, it goes far beyond the "p <0.05" approach that is (still) bandied about in many medical journals.
There is very little code (mostly R), which I think is important for a book like this one. I definitely got the impression the author wants the reader to spend time understanding the material and some of the choices he suggests rather than spending time understanding code.