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Colic Solved: The Essential Guide to Infant Reflux and the Care of Your Crying, Difficult-to- Soothe Baby Paperback – February 27, 2007

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Editorial Reviews

About the Author

Bryan Vartabedian, M.D., F.A.A.O., is a pediatric gastroenterologist in Houston, TX, who writes frequently about children's health issues. He is married and the father of a son who will eat just about anything. He is the author of "First Foods".

Excerpt. © Reprinted by permission. All rights reserved.



If your baby screams, she’s not alone. It’s estimated that about 1 of 5 babies have unexplained irritability. It’s been 50 years since the initial pigeonholing of irritable babies with a condition that we’ve affectionately come to call colic. At the time that colic was first described, doctors had few means of knowing what was going on inside a baby. And in the absence of any better explanation, the idea of a five-letter word to sum it all up was warmly received. And despite what we have come to know, colic as a wastebasket diagnosis remains alive and well, a vestige of history and a comfortable place to put the babies we have such a hard time with. But your baby is screaming for a reason. It’s a cry for help.


Hannah was 2 months old when she first visited me in my Houston office. Her pediatrician had referred her because he had exhausted all of his resources as a busy primary care pediatrician. Hannah wouldn’t stop crying, and he didn’t know why. The best explanation this seasoned and reputable pediatrician had was that Hannah had colic.

Her problems began at around 2 weeks of age when she began crying after her feeding. Her crying progressed to throughout the day and started to affect her feeding. The pediatrician advised that her mother discontinue breastfeeding her because he feared that breast milk was the problem. Formula feeds began strong, but after a half ounce became difficult, with Hannah arching, pulling from the nipple, and in apparent pain, all while still being hungry and wanting more. The frustration of Hannah’s hour-long feeding episodes were matched only by her sleep, which was regularly interrupted with piercing screams and painful gas.

Her waking hours were marked by nearly constant hiccups and the need to be held and moved. Hannah’s parents were told that she had colic, yet colic medication never seemed to make much of a difference. Formula changes became nearly as frequent as diaper changes, but nothing seemed to make a difference.

The baby’s incessant irritability, impossible feeding, and unpredictable sleeping patterns soon began to take its toll on her parents. When her mother returned to work when Hannah was 3 months old, understanding day care was hard to come by. At the end of their rope with a marriage at its limits, Hannah’s parents came to see me.


Whether it’s a pleasure or not, I have the opportunity to work with babies like Hannah every day. Thousands of screaming, miserable, sleepless, and impossible-to-feed babies have found their way to my office over the past several years, some sicker than others, but all delivered by desperate parents looking for answers and looking for help. This book is about what I’ve learned and what I know.

I’ve always said that it was far easier being a pediatrician before I ever had children of my own. Calls in the middle of the night from the sleepless parents of screaming babies were handled as a matter of course early on in my career. But despite my comforting words, my attitude beneath was “Deal with it.” I had bought into the idea that all babies scream and that some babies scream because of the stress and pressure that young parents convey to their babies. While I have always done my best to evaluate and treat every baby thoroughly, I was very much inside the system at first . . . a paternalistic, board- certified know-it-all with 6 years of residency and fellowship training at America’s largest children’s hospital. But I had never lived with a baby. More important, I had never lived with a baby with reflux.

The birth of my daughter, Laura, represented a turning point for me as a pediatrician. Laura was a lot like Hannah, with the exception that her father was a pediatric gastroenterologist. And with that came expectations from my wife to make things better. Laura was treated for acid reflux and morphed from a bundle of misery to something far more tolerable. I was vindicated as both a father and a physician, and my view of the screaming baby has never been the same.

I should note that my son, Nicholas, happily spit everywhere and all the time until nearly a year of age. But for us this was nothing more than an inconvenience. In nearly all of his baby pictures, he is wearing a crusty burp bib intended to protect the expensive outfits we bought him as the firstborn. So you could say that I’ve had it both ways: a bundle of misery and a happy spitter, two patterns that you’ll read about in Chapter 3, “Seven Signs of Reflux in Your Baby.”

For better or worse, I can now empathize with the families I see—for better because I can understand their situation and react to it more sensitively; for worse because I can understand their situation and relive the misery that they feel whenever I’m called to evaluate a screamer.


Unfortunately, not everyone has a pediatric gastroenterologist as a father. In many cases, babies are left alone to cry, either by parents who don’t know how to advocate for them or by doctors who don’t know where to turn. In fact, in Hannah’s case the diagnosis was colic because there was nothing else to explain her problem and the symptoms loosely fit with something that her pediatrician had been taught many years ago.

So What Is Colic?

The quest for the cause of colic or even an agreed-on definition of it over the last half century has amounted to something of an optical illusion. Like one of those abstract images that you must stare at for minutes on end before actually identifying the picture, colic has been something of an elusive diagnosis among pediatricians. And the many who never quite see it ultimately agree that they see it just so they won’t have to continue squinting.

I’ll have to admit that from early on in my career I was never able to see the pretty picture when it came to the illusion of colic. While I’ve evaluated and treated thousands of irritable babies, the problem is that I’ve never seen colic and can’t get straight answers about what it is or what it looks like from those who claim to have seen it. Like the UFOs that seem to land everywhere but at Harvard and MIT, colic has evolved into one of our culture’s greatest urban legends—a mythical explanation meant to explain the seemingly unexplainable.

A Baby Cannot “Have” Colic

The problem comes with the fact that colic is a description and not a disease. This descriptive term has, in turn, been morphed into a real and recognizable condition that served an important role for parents and pediatricians in our not-so-distant past. Much as fables and myths help provide order and explanation for different cultures, colic was once a comfortable resting place for weary pediatricians dealing with weary parents. And when medical science failed to offer any better explanation, it served to conveniently absolve the pediatrician from any further responsibility to parent or child.

Because colic represents a pattern of behavior and not a disease, a baby cannot “have” colic or have it “diagnosed.” Much like fever or weight loss that typically represent signs of some other problem in a child, colic doesn’t stand on its own as a diagnosis. To use the words diagnosis and colic together suggests that intelligent, established criteria, backed up by clinical research, were used to come to that conclusion. But unfortunately, such criteria or compelling clinical studies don’t exist. In the words of a distinguished researcher on the topic of infant irritability recently quoted in the Journal of Pediatric Gastroenterology and Nutrition, “The term colic implies a mechanism responsible for the distress displayed by these infants. Such a mechanism has never been demonstrated.”

Colic—Whatever You Want It to Be

But colic advocates and researchers who have built their careers on the urban legend that is colic will beg to differ. The criterion they use, as determined in 1954, suggests that the diagnosis should be considered in babies who experience inconsolable screaming for 3 days a week, for 3 hours a day, for at least 3 weeks a month. Unfortunately, if your baby screams for only 2 hours and 45 minutes for only 20 days straight, you’re a day early and a dollar short. Had I created criteria for colic, I would have suggested adding the fact that you haven’t had sex with your spouse in 3 months, you’re up 3 hours each night, and you’re 3 weeks away from losing your job unless you get some sleep. But I wasn’t practicing in the 1950s, and things were different then.

If we give our 1950s’ researchers the benefit of the doubt and accept the out-of-thin-air rule of threes, as it is called, not everyone sticks to it. In fact, when it comes to the diagnosis of colic, everyone seems to have his or her own rules. A colleague whom I work closely with will diagnose colic only if the baby cannot be put down. Another employs a white-noise rule—the diagnosis is confirmed if the baby settles with the sound of a vacuum cleaner, hair dryer, or other loud neutralizing sound. It seems that the number of random, self- imposed criteria for diagnosis are limited only by the imagination.

So despite the complete absence of a consensus of what constitutes colic, it remains nonetheless a convenient wastebasket diagnosis that can be retrofitted to suit the need of the individual making the diagnosis. If you haven’t caught on, colic would appear to be a well- orchestrated five-letter defense mechanism for doctors who are either outdated, outwitted, or just plain out of ideas.



Our experience and medical research tell us that babies scream for a reason. While Colic Solved doesn’t intend to suggest that there aren’t high-need babies or those with sensitive developing nervous systems, it is here to introduce the idea that something physical may in fact be wrong.

In a sense, this book is the result of a revolution in pediatric medicine—a culmination of technology and insight. Advances in endoscopy (viewing the inside of body organs or cavities with a device that uses flexible fiber optics), pharmacology, and nutrition have allowed us to rethink why babies cry. In the twentieth century, we called it colic only because no one knew any better. And while developments in conquering diseases such as polio and smallpox obviously take center stage, other seemingly less impressive advances are important minor characters. Our understanding of the irritable baby is one of them.

Technology Has Changed Our Babies for the Better

So what are the changes in pediatric health care that have created a better understanding of why babies do what they do?

•The creation of pediatric gastroenterology as a specialty. While there have been pediatricians dedicated to the understanding of pediatric digestive health since the early 1900s, it was the formal organization of the field of pediatric gastroenterology that has created an atmosphere of

organized discussion and research. The subspecialty of pediatric gastroenterology was recognized by the American Board of Medical Specialties in 1988, and since then the number of trained gastrointestinal (GI) specialists conducting research and setting the standards of care has continued to grow. Alongside the expansion of gastroenterology as a pediatric subspecialty has been the development of smaller endoscopes (flexible-tube optical instruments that use fiber optics to illuminate the inside of the intestinal tract) for understanding what happens in a baby’s digestive system. pH probes came into popular use by pediatric gastroenterologists in the 1980s, allowing doctors to begin to associate patterns of reflux with patterns of irritability. (pH is a measure of acidity or alkalinity of a substance.)

•Identification of reflux as a key contributor to a number of common conditions. Beyond simply understanding acid reflux (the backflow of stomach acid into the esophagus, the muscular tube that carries food and drink to the stomach) in babies, this evolution of technology involving fiber-optic endoscopes and pH probes has allowed the correlation of reflux with other problems such as asthma, sinus conditions, and feeding disorders.

•The advancement of infant nutrition. Understanding of the growing immune system has led to the development of hypoallergenic formulas, specifically superhypoallergenic formula, which became available for common use in the early 1990s. This has revolutionized the care and feeding of the infant with severe allergic disease. Our ability to understand the reactions of the intestinal immune system has been furthered by our ability to “see” intestinal allergy with endoscopic technology. And while we continue to learn more and more about the incredible benefits of breastfeeding, formula manufacturers are learning from it to benefit babies who can’t breastfeed. Formulas, which were once nothing more than a vehicle for protein, fat, and carbohydrate, now sometimes contain long-chain fatty acids that have been shown to improve visual and cognitive function in infancy and beyond.

•The evolution of pediatric drug development. The development and improvement of safe, effective antacids for use in children have revolutionized the way we see and care for the screaming baby. The technology of drug delivery has provided pediatricians with more options for facing the challenge of administering medicine to infants and children. And recent changes in federal law now mandate clinical trials (research studies) in children for many of the new drugs being released for adults.

•The popularization of the Internet. While many doctors consider it a curse, the Internet has empowered parents to network and ask questions about their baby’s misery. Parents whose babies have been dealt the once dead-end diagnosis of colic now are learning in chat rooms and on Web sites that there may be identifiable and treatable problems at work. While the Web has the downside of sometimes offering too much information, its ability to raise questions is unparalleled.

So as we enter the twenty-first century, it sure seems like a great time to be a baby, particularly one who screams. All of these developments have made it easier to help the fussy baby.

Why Hannah Is Screaming

We now know that children with the type of irritability described as colic often suffer with either reflux or milk protein allergy.

A major study reported in 2004 by one of the world’s most respected reflux researchers created quite a stir in the medical community. Clinical researchers treated a group of irritable babies with hypoallergenic formula. The babies whose symptoms didn’t lessen when they were given hypoallergenic formula were then evaluated for the presence of gastroesophageal reflux using endoscopy and a pH probe (you’ll learn more about these in Chapter 8, “A Parent’s Guide to Tests and Studies,” but for now understand that this is how reflux is formally assessed). Of 60 markedly irritable infants between the ages of 1 and 6 months, 66% had pH probe results consistent with abnormal reflux and 43% had evidence of acid reflux injury shown by biopsy of the esophagus. While the report’s authors make it clear that proving an absolute cause-and-effect relationship between crying and obvious reflux can be difficult, the results are thought-provoking.

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Product Details

  • Paperback: 320 pages
  • Publisher: Ballantine Books; 1 edition (February 27, 2007)
  • Language: English
  • ISBN-10: 0345490681
  • ISBN-13: 978-0345490681
  • Product Dimensions: 5.2 x 0.5 x 8 inches
  • Shipping Weight: 7.8 ounces (View shipping rates and policies)
  • Average Customer Review: 4.7 out of 5 stars  See all reviews (99 customer reviews)
  • Amazon Best Sellers Rank: #110,520 in Books (See Top 100 in Books)

Customer Reviews

Top Customer Reviews

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My daughter was diagnosed with both colic and "silent" reflux. At her worst, she fussed inconsolably fourteen hours a day. With the medication and techniques recommended in this book, her fussy periods went down to two to four hours a day, and the symptoms of acid reflux disease dramatically decreased (e.g. she slept longer, ate more, agreed to stay on her back, and had no more painful hiccups and wheezing.) An improvement? Yes! Tremendous! ... but she still had colic. So, I'm glad I bought this book, and I would buy it again, but I can't give it an unqualified recommendation for a couple reasons.

(1) I had more questions.

Dr. V takes the position that "colic" is really undiagnosed acid reflux or milk protein allergy--treatable conditions. And make no mistake, he advises treatment. In the chapter subtitled, "To treat or not to treat?" He writes:

Because of all the variables, the decision to treat is often unfortunately based on the time and effort put forth by the physician... as well as the parents' ability to assertively detail their baby's experience. If any of these parties charged with advocating for the baby's health fails... the result is untreated symptoms and frustration. (171)

Translation: if you are an effective advocate for your child, you will get treatment for acid reflux. In this view, there are basically two kinds of physicians: the enlightened and the uninformed. However, a few seconds on Google with the search terms, "infant acid reflux ppi placebo" reveals a third group: the unconvinced.
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With a five month old that seems to be in physical pain, crying real tears frequently, arching his back, feeding all of the time and gaining weight rapidly I know something isn't quite right. He's rarely happy, even after a feeding. Our doctor said he seems to be colicky, game me some literature and sent us home. I've since read Colic Solved and know something needs to be done. He has many of the symptoms of acid reflux, a gray-zone baby, and now I feel like I have the tools and knowledge to help my son feel better.

The book is very easy to read, and Dr. V puts all of the medical-ease into a layperson's terms. It's been invaluable as a resource in understanding what my son is going through right now. The book also has a chapter on things you can try at home while you're in the process of dealing with doctors and waiting for answers. These are very helpful and easy to implement.

I also have a 2 1/2 year old who does have acid reflux and dysphagia. The book has also given me great insight into what he went through as a "colicky" baby. He wasn't diagnosed with reflux or dysphagia until he was 15 months old - if only we'd had this book then we could have prevented some of his discomfort and probably some of his swallowing difficulties. Knowing what I know now from Colic Solved, I know without a doubt that something has to be done to get my 5 week old some comfort.


I highly recommend this book to anyone who has a fussy infant!
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By Dee on February 25, 2014
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I'm quite happy with the read - i now know, how much ever there is to know, about what is causing my infant to cry so much.

But im not happy that for breastfed babies there isn't any solutions listed out in this book.
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By Mommy of 2 on September 24, 2009
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If you have an infant who cries constantly and you are at your wits end, you need to get this book! This book saved my sanity! My daughter started crying non-stop when she was about 2 weeks old. The doctor diagnosed her with reflux and put her on zantac....however, the crying persisted.It was only after I read this book that I discovered what was truely wrong with her. In the book he describes the correlation between reflux and milk allergy in infants. Low and behold, our daughter is allergic to milk, soy, and eggs. If it wasn't for this book we would still be listening to her cry, believing it was just "colic." After reading "The Happiest Baby on the Block," I felt like such a failure....this book help me to realize that until you SOLVE the problem of painful reflux, or milk allergy, the 5 S's won't do a darn thing!!! PLEASE get this book if you are dealing with the same thing. Your infant deserves peace and so do you!
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Dr. Vartabedian's thesis is that "colic" is essentially acid reflux as the source of unexplained crying in babies. The book was very helpful in identifying my child's symptoms and remedies. However, he has since published a video (find on you tube) to express his interest and efficacy of probiotics with colic. All the major studies of probiotics came out after he published this book.
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As early as he was 2 weeks old, my son began to show all the symptoms of acid reflux and milk + soy protein allergy. In fact, I believe that he had the symptoms when he was in the uterus--he used to get minutes long hiccups everyday (when I was pregnant, we thought it was funny--not a laughing matter anymore!)and every night at around the same time would start kicking so hard, I couldn't move or bend, but just had to lay on my left side for hours, until he'd fall asleep-- Our pediatrician (we have a new one now!) said my son "had colic" When we asked him what colic was, he couldn't really describe it except he said that his daughter had it too, and that white noise and driving in the car helped them a lot. Well, it didn't help us! My son would cry at the top of his lungs every night (later, during the day too), arch, writhe, scream, and spit up. He was restless in his sleep, and very irritable during the day. I didn't buy into the whole vague "colic" term, adn did my own research. Then, I found this wonderful, life-saver book. I read it overnight (as I cried listening to my baby cry), and immediately came to the conclusion that my son had BOTH acid reflux and milk protein allergy. Then I did a search on NASPHGAN and found a specialist. After 5 weeks of treatment my son is doing somewhat better now, we KNOW why he's crying and what to do to console him.

Do not hesitate to buy this book, and read it ASAP. It'll be best thing you've ever done for your screaming baby. It's written for the general folk, but it's very informative. I personally found all the answers I was looking for, and now am keeping it on my side table, next to our burping cloths. And like the author says, if your pediatrician drops the C bomb (for colic), look somewhere else. We did.
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