From the Back Cover
Approaches to the recovery of three-dimensional information on a biological object, which are often formulated or implemented initially in an intuitive way, are concisely described here based on physical models of the object and the image-formation process. Both three-dimensional electron microscopy and X-ray tomography can be captured in the same mathematical framework, leading to closely-related computational approaches, but the methodologies differ in detail and hence pose different challenges. The editors of this volume, Gabor T. Herman and Joachim Frank, are experts in the respective methodologies and present research at the forefront of biological imaging and structural biology.
Computational Methods for Three-Dimensional Microscopy Reconstruction will serve as a useful resource for scholars interested in the development of computational methods for structural biology and cell biology, particularly in the area of 3D imaging and modeling.--This text refers to the Hardcover edition.
About the Author
Dr Joachim Frank is a Howard Hughes Medical Institute Investigator, Professor of Biochemistry and Molecular Biophysics and Professor of Biological Sciences at Columbia University. He has received many awards for his research, including, with David DeRosier, the Elizabeth Robert Cole Award of the Biophysics Society. He has published more than 200 peer-reviewed articles, written numerous book chapters and authored or edited five books, including Electron Crystallography of Biological Macromolecules, edited with Kenneth Downing, David DeRosier and Wah Chiu (2007) and Electron Tomography, 2nd edition (2010). --This text refers to the Hardcover edition.