A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution Kindle Edition

4.3 out of 5 stars 35 customer reviews
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ISBN-13: 978-0544716940
ISBN-10: 0544716949
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Editorial Reviews

Review

“The first book on CRISPR to present a powerful mix of science and ethics…This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”
—New York Review of Books

“Fascinating… When people refer to CRISPR now, they talk about wiping out disease, resurrecting woolly mammoths, and fashioning designer babies. Such implications fascinate and torment Doudna, and she writes about them movingly with Samuel Sternberg, a biochemist and former research colleague, in A Crack in Creation.”
Bloomberg Businessweek

"An invaluable account, by Doudna and Samuel Sternberg, of their role in the revolution that is genome editing...It is unusual to have a popular account of a great scientific breakthrough written by the protagonist, so soon after its discovery. Watson’s The Double Helix appeared 15 years after the work. We owe Doudna several times over – for her discovery, for her zeal to take it from the lab into the clinic, for her involvement in the ethical issues raised, for her public engagement work, and now for this book. It’s a fine weapon against the still far too large tribe of those who don’t believe in the power of very small things."
Guardian (UK)

A Crack in Creation is a powerful testament to the role of curiosity and tenacity in scientific research, and also an urgent plea from the celebrated biologist whose discovery enabled us to rewrite the code of life.  The future is in our hands as never before, and this book explains the stakes like no other.”
—George Lucas, filmmaker

“Urgent, riveting, and endlessly fascinating, A Crack in Creation is a journey through the past, present, and future of one of biology’s most significant discoveries. Combining deep historical perspectives, personal narrative, and scientific data, Doudna and Sternberg bring the story of CRISPR and ‘gene editing’ alive with pointed honesty and clarity. This book is destined to become an instant classic. Read it and understand its implications if you want to understand our biological future.”
—Siddhartha Mukherjee, Pulitzer Prize–winning author of The Gene and The Emperor of All Maladies

“The technology of gene editing will be the most important advance of our era, one that will create astonishing opportunities combined with frightening moral challenges. In the tradition of The Double Helix, one of the pioneers of the field describes the exciting collaborative and competitive hunt for the key breakthrough and what it portends for our future.”
—Walter Isaacson, bestselling author of Steve Jobs, Einstein, and The Innovators

A Crack in Creation, by one of the most pioneering women in science, is both exhilarating and frightening. Jennifer Doudna and her co-author Samuel Sternberg challenge us to confront the possible dangers of gene editing, even as we embrace its incredible potential. This book is a roadmap to our future.”
—Arianna Huffington, bestselling author of Thrive and The Sleep Revolution
 
“Jennifer Doudna is the true pioneer who built the bridge between the basic science of CRISPR and its diverse applications in agriculture and medicine.  Writing with Samuel Sternberg, she has crafted a beautifully written book with A Crack in Creation—a pure pleasure for both neophyte and expert. Now is the time to read about the revolution that could change our world.”
—George Church, Professor of Genetics at Harvard Medical School and author of Regenesis

“We are developing ever more powerful tools that allow us to change the genetic makeup not only of life around us but also of ourselves. Describing the potential benefits of these tools as well as some of the risks and ethical issues they present to society, A Crack inCreation is a scientific thriller and a gripping read, framed as a personal voyage by a brilliant scientist who played a major role in developing what is currently one of the most promising and powerful ways of editing our genomes.”
—Venki Ramakrishnan, president of the Royal Society and winner of the Nobel Prize in Chemistry

"[A Crack in Creation] contribute[s] to a public understanding of CRISPR, explaining science in terms that are understandable for the general reader...Fascinating."
Wall Street Journal

“An enthusiastic and definitely not dumbed-down account of gene manipulation that, unlike earlier methods, is precise and easy...an important book about a major scientific advance.”
Kirkus Reviews, STARRED

“The authors describe the biological mechanisms in a way that nonspecialists can appreciate...excellent book.”
Publishers Weekly

"A Crack in Creation chronicles the origin and potential application of CRISPR, the powerful new gene-editing technique that established Doudna as a household name in scientific circles...The first section begins with a history of gene-editing technology and how these research endeavors were largely propelled by the quest to eradicate genetic diseases...Reviewing the fundamentals will enable your imagination to unspool. You'll find yourself pausing to plot your own CRISPR-inspired science project—or science fiction scenario...In the second half of the book, the authors outline the staggering potential applications of CRISPR technology...The narrative between the lines that propels the book forward."
Science

About the Author

JENNIFER A. DOUDNA, Ph.D. is a professor in the Chemistry and the Molecular and Cell Biology Departments at the University of California, Berkeley, investigator with the Howard Hughes Medical Institute, and researcher in the Molecular Biophysics and Integrated Bioimaging Division at the Lawrence Berkeley National Laboratory. She is internationally recognized as a leading expert on RNA-protein biochemistry, CRISPR biology, and genome engineering. She lives in the Bay Area.


SAMUEL H. STERNBERG, Ph.D., will start his own laboratory as an assistant professor in the Department of Biochemistry and Molecular Biophysics at Columbia University, beginning in 2018. He presents his research to international audiences and has received the Scaringe Award and the Harold M. Weintraub Graduate Student Award, among other honors. He presently lives in the San Francisco Bay Area.

Product details

  • File Size: 15593 KB
  • Print Length: 307 pages
  • Publisher: Houghton Mifflin Harcourt (June 13, 2017)
  • Publication Date: June 13, 2017
  • Sold by: Houghton Mifflin Harcourt
  • Language: English
  • ASIN: B01I4FPNNQ
  • Text-to-Speech: Enabled
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  • Lending: Not Enabled
  • Enhanced Typesetting: Not Enabled
  • Amazon Best Sellers Rank: #7,230 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
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