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Cure: A Journey into the Science of Mind Over Body 1st Edition, Kindle Edition
| Jo Marchant (Author) Find all the books, read about the author, and more. See search results for this author |
Have you ever felt a surge of adrenaline after narrowly avoiding an accident? Salivated at the sight (or thought) of a sour lemon? Felt turned on just from hearing your partner's voice? If so, then you've experienced how dramatically the workings of your mind can affect your body.
Yet while we accept that stress or anxiety can damage our health, the idea of "healing thoughts" was long ago hijacked by New Age gurus and spiritual healers. Recently, however, serious scientists from a range of fields have been uncovering evidence that our thoughts, emotions and beliefs can ease pain, heal wounds, fend off infection and heart disease and even slow the progression of AIDS and some cancers.
In Cure, award-winning science writer Jo Marchant travels the world to meet the physicians, patients and researchers on the cutting edge of this new world of medicine. We learn how meditation protects against depression and dementia, how social connections increase life expectancy and how patients who feel cared for recover from surgery faster. We meet Iraq war veterans who are using a virtual arctic world to treat their burns and children whose ADHD is kept under control with half the normal dose of medication. We watch as a transplant patient uses the smell of lavender to calm his hostile immune system and an Olympic runner shaves vital seconds off his time through mind-power alone.
Drawing on the very latest research, Marchant explores the vast potential of the mind's ability to heal, lays out its limitations and explains how we can make use of the findings in our own lives. With clarity and compassion, Cure points the way towards a system of medicine that treats us not simply as bodies but as human beings.
A New York Times Bestseller
Finalist for the Royal Society Insight Investment Science Book Prize
Longlisted for the Wellcome Book Prize
- ISBN-13978-0385348157
- Edition1st
- PublisherCrown
- Publication dateJanuary 19, 2016
- LanguageEnglish
- File size1576 KB
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Editorial Reviews
Review
A New York Magazine Best Science Book of 2016
A Mindful.org Top 10 Mindful Book of 2016
A Sunday Times Book of the Year
An Economist Book of the Year
A Spirituality & Health Best Mind/Body Book of 2016
“Ms. Marchant writes well, which is never a guarantee in this genre… Second, [she] has chosen very moving characters to show us the importance of the research… and she has an equal flair for finding inspirational figures… the studies are irresistible, and they come in an almost infinite variety.”
—New York Times
“Cure is a cautious, scrupulous investigation of how the brain can help heal our bodies. It is also an important look at the flip side of this coin, which is how brains damaged by stress may make bodies succumb to physical illness or accelerated aging…Cure points a way toward a future in which the two camps [mainstream medicine and alternative therapies] might work together. After all, any medicine that makes a patient better, whether conventional, alternative, or placebo, is simply medicine.”
—Wall Street Journal
“A well-researched page-turner… raises questions about the role of culture, environment and neurochemistry in our responses to treatment—and may very well lead to widespread changes in the ways we practice medicine.”
—Susannah Cahalan, New York Post
“Cure is for anyone interested in a readable overview of recent findings in mind-body phenomena, a reliably enthralling topic… A rewarding read that seeks to separate the wishful and emotion-driven from the scientifically tested.”
—Washington Post
“Research-heavy but never dull, this revelatory work about the mind-body connection explains how the brain can affect physical healing.”
—Entertainment Weekly
“Marchant is a skeptical, evidence-based reporter—one with a background in microbiology, no less—which makes for a fascinating juxtaposition against some of the alternative treatments she discusses.”
—New York Magazine
"A thought-provoking exploration of how the mind can affect the body and can be harnessed to help treat physical illness."
—Economist
“In a wide-ranging and compelling new book, science journalist Jo Marchant explores whether the mind can heal the body… With lively, clear prose, Marchant surveys the evidence for the mind-body connection.”
—Science News
“Fascinating and thought-provoking. Marchant has travelled extensively around Europe and the US, talking to health workers and ordinary folk, to produce this meticulously researched book… Cure is a much-needed counter to a reductionist medical culture that ignores anything that doesn’t show up in a scan… [it] should be compulsory reading for all young doctors.”
—New Scientist
“A revved-up, research-packed explication of the use of mind in medicine, from meditation to guided visualisation. Marchant’s nimble reportage on the work of scientists in novel fields such as psychoneuroimmunology and her discussion of placebos are as fresh as her reminders of how stress and poverty affect wellbeing are timely."
—Nature
“Could my belief that I’m going to feel better in itself heal me? It’s a fascinating question, and one that British author Jo Marchant takes on with aplomb in her new book, Cure.”
—Spirituality & Health
“Writing with simplicity, clarity and style, and covering an enormous range of material, [Marchant] surveys with grace what we think we know, and what we would like to know, about the mysterious and troubling relationship between our minds and our bodies… [She] is level-headed, always with one foot planted in the worlds of science and reason. Though open-minded, she is rigorous, her gently skeptical tone reassures, and she gracefully skewers quackery.”
—The Guardian
“Thought-provoking… This new generation of evidence-based mind-body researchers has produced some remarkable findings, which Marchant analyses with elegance and lucidity."
—Times Literary Supplement
“Jo Marchant makes her case so cogently that it is hard to disagree [with her]… The author has a gift for writing that is both clear and vivid, and communicates complex ideas in a way that is comprehensible and uncondescending… This is surely an area of medicine whose time has come.”
—The Independent
"A diligent and useful work that makes the case for 'holistic' medicine while warning against the snake-oil salesmen who have annexed that word for profit."
—Sunday Times
“This is an important book, and one that will challenge those dismissive of efforts to investigate how our thoughts, emotions and beliefs might directly influence our physical wellbeing… The evolving science explored in Cure is intriguing and trailblazing, and Marchant's account of its pursuit is often gripping… There's a lot to this impressive book, and it has the potential to have the same dramatic impact on our understanding of our self as Norman Doidge's blockbuster, The Brain that Changes Itself.”
—Sydney Morning Herald
"Marchant explores the possibilities of psychology-based approaches to improving physical well-being in this open-minded, evidence-based account… A powerful and critically needed conceptual bridge for those who are frustrated with pseudoscientific explanations of alternative therapies but intrigued by the mind’s potential power to both cause and treat chronic, stress-related conditions."
—Publishers Weekly (starred review)
"A balanced, informative review of a controversial subject."
—Kirkus Reviews
"Cure represents a journey in the best sense of the word: a vivid, compassionate, generous exploration of the role of the human mind in both health and illness. Drawing on her training as a scientist and a science writer, Marchant meticulously investigates both promising and improbable theories of the mind’s ability to heal the body. The result is to illuminate a fascinating approach to medicine, full of human detail, integrity, and ultimately, hope.”
—Deborah Blum, author of The Poisoner’s Handbook and Love at Goon Park
“This is popular science writing at its very best. Cure beautifully describes the cutting-edge research going on in the fascinating—and until now, often unexplored—area of mind-body medicine. I would recommend this book to anybody who has a mind and a body.”
—Henry Marsh, author of Do No Harm: Stories of Life, Death, and Brain Surgery --This text refers to an alternate kindle_edition edition.
About the Author
Excerpt. © Reprinted by permission. All rights reserved.
Linda Buonanno hugs me as soon as we meet, and shows me upstairs to her small, first-floor apartment in a housing block just off the freeway in Methuen, Massachusetts. Her living space is tidy but densely packed with framed photos, scented candles and an overwhelming preference for the color green. She sits me at the table, in front of a perfectly laid out tea set and a plate of ten macaroons. The 67-year-old is plump with short, auburn hair and a girlish giggle. “Everyone thinks it’s dyed, but it isn’t,” she tells me. She hovers until I try a macaroon, then sits down opposite and tells me about her struggles with irritable bowel syndrome (IBS).
She talks fast. Her symptoms first struck two decades ago, when her marriage of 23 years broke down. Although she dreamed of being a hair- dresser, she was working shifts in a factory, running machinery that made surgical blades, juggling the 60-hour week with a court battle and caring for the two youngest of her four children. “I went through hell,” she says. Within a year of the split, she started suffering from intestinal pains, cramps, diarrhea and bloating.
The condition has affected her ever since, especially at stressful times such as when she was laid off from the factory. Their jobs outsourced to Mexico, the group of women with whom she had worked and bonded was scattered. She retrained as a medical assistant, hoping to find work in a
chiropractor’s office, but once she qualified she found that no one was hiring. When she did finally find a part-time job, she had to give it up because of the pain from her IBS.
The condition has destroyed her social life too. When the symptoms are bad, “I can’t even leave the house,” she says. “I’d be keeling over in pain, running to the bathroom all the time.” Even buying groceries re- quires staying within reach of a bathroom, and she lists the local facilities: one in the Market Basket, one in the post office down the street. “This is 20 years I’ve been doing this,” she says. “It’s a horrible way to live.” Now she has to juggle the condition with looking after her elderly parents— her mother lives alone, while her father, who suffers from dementia, is in a nursing home. Linda’s brother was killed in Vietnam, and her twin sister died of cancer 18 years ago, so she is the only one left to help them.
She brightens. “But I travel,” she says. “I go to England, I do every- thing. I love it.” I’m thrown by this statement until I realize that she’s talking about Google maps. I ask her to show me, and we move over to her computer, which sits on a desk squeezed between the sofa and the micro- wave. She fires up the maps program and lands us on top of Buckingham Palace in London.
Suddenly I get a sense of how much time Linda has spent in this flat. She knows the layout of the palace intimately, zooming in to try to peek through the windows, then flying around the back to check out the private gardens. Other favorite destinations include the Caribbean island of Aruba, and the celebrity mansions of Rodeo Drive. Sometimes she looks up the addresses of her old workmates from the factory, friends who when they lost their jobs moved away to Kentucky or California, places that because of her IBS, and the demands of her parents, she can never visit for real.
Over the years, Linda has, like many patients with irritable bowel syn- drome, been passed from doctor to doctor. She has been tested for intol- erances and allergies, and has tried cutting out everything from gluten and fat to tomatoes. But she found no relief until she took part in a trial led by Ted Kaptchuk, a professor at Harvard Medical School in Boston. It was a trial that would revolutionize the world of placebo research.
• • •
“You know I’m deviant?” Ted Kaptchuk looks straight at me and I get the sense that he is rather proud of this fact.1 “Yes,” I answer. It’s hard to read anything about the Harvard professor without coming across his unusual past. In fact it seeps from every corner of our surroundings—the house where he lives and works, on a leafy side street in Cambridge, Mas- sachusetts.
I’m asked to remove my shoes as I enter, and offered a cup of Earl Grey tea. Persian rugs cover the wooden floors, and proudly displayed in the hall is a huge brass tea urn. The décor is elegant, featuring period furniture, modern art and shelves filled with books—rows of hardbound doorstops embossed with gold Chinese lettering next to English volumes, from The Jewish Wardrobe to Honey Hunters of Nepal. Through the win- dow I glimpse the nuanced greens and pinks of a manicured ornamental garden that might be more at home in Japan.
Kaptchuk himself has gold rings, big brown eyes and a sweep of gray- ing hair topped by a black skullcap. He likes to quote from historical man- uscripts, and his answers to my questions are accompanied by long pauses and a furrowed brow. I ask him to tell me his own version of the path that brought him here and he says it started when he was a student and he traveled to Asia to study traditional Chinese medicine.
It’s a decision he attributes to “sixties craziness. I wanted to do some- thing anti-imperialist.” He was also interested in Eastern religions and phi- losophies, and the thinking of the Chinese Communist leader Mao Zedong. “Now I think that was a really bad reason to study Chinese medicine. But I didn’t wanted to be co-opted, I didn’t want to be part of the system.”
After four years in Taiwan and China, he returned to the U.S. with a degree in Chinese medicine and opened a small acupuncture clinic in Cambridge. He saw patients with all sorts of conditions, mostly chronic complaints from pain to digestive, urinary and respiratory problems. Over the years, however, he became more and more uncomfortable with his role as a healer. He was good at what he did—perhaps too good. He would see dramatic cures, sometimes before patients had even received their treatment. “I would have patients who left my office totally differ- ent,” he says. “Because they sat and talked to me, and I wrote a prescrip- tion. I was petrified that I was psychic. I thought, Shit, this is crazy.”
Ultimately, Kaptchuk concluded that he didn’t have paranormal pow- ers. But equally, he believed that his patients’ striking recoveries didn’t have anything to do with the needles or the herbs he was prescribing. They were because of something else, and he was interested in finding out what that something was.
In 1998, Harvard Medical School, just down the street from Kaptchuk’s clinic, was looking for an expert in Chinese medicine. The U.S. National Institutes of Health (NIH) was opening a center dedi- cated to funding scientific research into alternative and complementary medicine. Although tiny compared to existing NIH centers investigating cancer, for example, or genetics, it promised to be a useful new source of research dollars for Harvard. “But no one there knew a thing about Chinese medicine or any kind of alternative medicine,” says Kaptchuk. “So they hired me.”
Rather than study Chinese medicine directly, however, he decided to investigate the placebo effect, to find out whether this could explain why his patients did so well. Whereas Benedetti is interested in the molecules and mechanics of the placebo effect, Kaptchuk’s focus is on people. The questions he asks are psychological and philosophical. Why should the expectation of a cure affect us so profoundly? Can the placebo effect be split into different components? Is our response affected by factors such as the type of placebo we take, or the bedside manner of our doctor?
In one of his first trials, Kaptchuk compared the effectiveness of two different kinds of placebo—fake acupuncture and a fake pill—in 270 pa- tients with persistent arm pain.2 It’s a study that makes no sense from a conventional perspective. When comparing two inert treatments— nothing with nothing—you wouldn’t expect to see any difference. Yet Kaptchuk did see a difference. Placebo acupuncture was more effective for reducing the patients’ pain, whereas the placebo pill worked better for helping them to sleep.
This is the problem with placebo effects—in trials they are elusive and ephemeral, rarely disappearing completely but often altering their shape. They change depending on the type of placebo, and they vary in strength between people, conditions and cultures. For example, the percentage of people who responded to placebo in trials of a particular ulcer medication ranged from 59% in Denmark to just 7% in Brazil.3 The same placebo can have positive, zero or negative effects depending on what we’re told about it, and the effects can change over time. Such shifting results have helped to create an aura around the placebo effect as something slightly unscientific if not downright crazy.
But it isn’t crazy. What these results actually show, says Kaptchuk, is that scientists have long gotten their understanding of the placebo effect backwards. When he arrived at Harvard, he says, the experts there told him that the placebo effect “was the effect of an inert substance.” It’s a commonly used description but one that Kaptchuk describes as “com- plete nonsense.” By definition, he points out, an inert substance does not have any effect.
What does have an effect, of course, is our psychological response to those inert substances. Neither fake acupuncture nor a fake pill is in itself capable of doing anything. But patients interpret them in different ways, and that in turn creates different changes in their symptoms. --This text refers to an alternate kindle_edition edition.
Product details
- ASIN : B00WPQ98X2
- Publisher : Crown; 1st edition (January 19, 2016)
- Publication date : January 19, 2016
- Language : English
- File size : 1576 KB
- Text-to-Speech : Enabled
- Screen Reader : Supported
- Enhanced typesetting : Enabled
- X-Ray : Not Enabled
- Word Wise : Enabled
- Sticky notes : On Kindle Scribe
- Print length : 289 pages
- Best Sellers Rank: #486,575 in Kindle Store (See Top 100 in Kindle Store)
- #272 in Neuropsychology (Kindle Store)
- #586 in Medical Neuropsychology
- #745 in Alternative Therapies
- Customer Reviews:
About the author

Jo Marchant is an author and journalist based in London. Her books tackle the story of humanity, from the wonders of ancient civilisations to the mysteries of our bodies and brains. Her upcoming book, The Human Cosmos (to be published in September 2020), tells the story of our intimate relationship with the night sky and the universe beyond.
Jo’s most recent book, the 2016 New York Times bestseller Cure: a journey into the science of mind over body, was shortlisted for the Royal Society science book prize, longlisted for the Wellcome Book Prize and named a book of the year by The Economist and The Sunday Times. Jo’s other books are The Shadow King: The bizarre afterlife of King Tut’s mummy (2013) and Decoding the Heavens: Solving the mystery of the world’s first computer (2009), which was also shortlisted for the Royal Society science book prize.
Jo trained as a scientist: she has a PhD in genetics and medical microbiology from St Bartholomew’s Hospital Medical College in London, and an MSc in Science Communication from Imperial College London. She previously worked as a senior editor at New Scientist and at Nature, and her articles have appeared in publications including The New York Times, The Washington Post, The Guardian and Smithsonian magazine.
Her radio and TV appearances include BBC Radio 4’s Start the Week and Today programmes, NPR’s Fresh Air, CNN and National Geographic. She has captivated audiences around the world, including at the World Science Festival in New York, the Royal Institution in London, Hay Festival, Edinburgh Science Festival, the Emirates Literature Festival in Dubai and the Dutch-Flemish Institute in Cairo.
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Medicine used to be an art that was full of superstition and sample sizes of one or two. Shaman had the advantage of generations of cultural experience. But then came science and the double blind placebo controlled study with large sample sizes that cost millions. Big Pharm loved this because they could bear the cost and filter the publication of results. If there wasn’t a potentially huge payoff at the end the research was simply not done—to heck with folk medicine, cheap supplements, and inexpensive cures. But recently neuroscience and epigenetics have generated a whole new paradigm of treatments based on mind-body interaction that do not lend themselves to the traditional methodology. This book is all about this paradigm shift. Here are some mind-blowing findings:
A placebo for amphetamine, a Parkinson’s drug, can flood the brain with dopamine just like the actual drug. The patient’s body becomes erect; shoulders go back in the normal posture. So too when saline is substituted for apomorphine in implanted chemical brain stimulation of subthalamic nucleus otherwise Parkinsonians can control their movements.
Fake oxygen administered at altitude to an anoxic mountain climber can mimic the effect of oxygen to improve climbing performance although there is no increase in the climber’s blood oxygen.
Valium has no effect on anxiety unless the patient knows they are taking it. Antidepressants like Prozac have little effect over placebos. Patients recovering from surgery were given painkillers intravenously either automatically or with a physician present telling the patient what was happening. With the Doc present the patients got 50% more relief. Long suffering and desperate irritable bowel syndrome patients have reported pain relief even when they were told ahead of time that they were taking a placebo.
ADHD children could get the same drug relief with half the dose when all doses were paired with a distinctively colored placebo first with the full dose for a month and then with a half dose. But when controls without the placebo were reduced to half dose after a month they regressed.
Lonely elderly people have compromised immune responses attributable to the up and down regulation of the genes that control immunity. The same genes are oppositely regulated in highly social people. Experiments with rats normally mothered compared to those that weren’t licked and nurtured by their mothers show that the neglected rats have all kinds of aberrant behavior and the differences are associated with the up and down regulation of specific genes. The survival of oncology patients is highly correlated with how they rate their quality of life. Those who rate their quality of life as poor have double the risk of dying from cancer.
Meanwhile our medical interventions do far more harm than less invassive treatments. Psychiatric drugs are responsible for half a million annual deaths in the Western world. Errors in hospitals cause 400,000 annual deaths in the US. Another 100,000 Americans are killed by adverse drug reactions. It is time to revise our consideration of treatment and how we decide what is worth studying, less invasive, more affordable.
In my opinion, real science actively seeks explanation of the unexplained. In that regard, there seems to be very little real science going on the field of healing and medicine. Much evidence of unexplained phenomena is summarily tossed out as "anecdotal". Anything that cannot be explained by Newtonian physics is ignored, rather than seriously studied, even when it is well-documented. (Of course, most scientists recognize the incompleteness of the Newtonian description of the Universe.)
The effect of human intention on the behavior of plants, animals, people, and scientific experiments (even "blind" and "double blind") has been documented for over 60 years. Many healing modalities depend on "intention" and/or the manipulation of "energy." The number of people who depend on alternative medicine, either as practitioners or patients, is non-trivial. The title of Marchant's book suggests that these effects and experiences would be explored in some detail, rather than summarily dismissed. I know of one researcher who gave up experiments in remote and intentional healing (of cancer in mice) because the students he trained were too disturbed by their success: it went against everything they "knew." I suspect Marchant would have similar difficulty reconciling the results with her world view.
Top reviews from other countries
The author, Jo Marchant, presents some eye-opening findings & explores some alternative approaches from simple quality of life care to the faith healing of Lourdes.
Well worth the read, and the audiobook form made the subject more accessible to me.
important to me. Jo is knowledgeable and writes with compassion and depth and in my opinion, if interested in health and wellbeing this would be a most helpful and fascinating book.
I wish I could give clearer information on each chapter but it is a while since reading it and I have let a friend borrow it for now. I can say that if you are fascinated by health issues and are perhaps looking for deeper answers than the usual websites offer, as I am, then you will find this book useful and interesting.
The author comes across as both honest and inquisitive, and touches on alternative approaches to healing, how our environments effect our health, and how the mind maybe harnessed toward healing.
Worth a read.
Thank you Jo for such a great read. :-)








