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Doctor's Best Lumbrokinase, Cardiovascular Support, Circulatory Health, Blood Flow, Enzymes, 20 mg, 60 VC (DRB-00181)

4.6 out of 5 stars 173 ratings
Amazon's Choice recommends highly rated and well-priced products.
Amazon's Choice for "lumbrokinase"

Price: $38.84 ($0.65 / Count)
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60 Count (Pack of 1)
  • DOCTOR’S BEST LUMBROKINASE- is a highly active enzyme that may be used to support healthy cardiovascular function. Helps to maintain healthier blood and lower blood viscosity.
  • UNIQUE ENZYMES - Lumbrokinase consists of a group of highly stable fibrinolytic enzymes, that have been studied and utilized extensively in China for many years. Lumbrokinase is a group of fibrinolytic enzymes originally derived from the earthworm Lumbricus rubellus.
  • CLINICAL STUDIES – a study reinforces the effect of lumbrokinase on blood circulation and showed a decrease in blood viscosity significantly. By reducing fibrinogen resulted in fibrinolysis, a breakdown of blood clots.
  • OPTIMAL ABSORPTION - Each vegetarian capsule contains pure lumbrokinase designed for optimal absorption in the intestinal tract. The enzyme activity is measured in units: Lumbrokinase 20mg is equal to 360,000 units of enzyme activity.
  • Non-GMO, Soy Free, Gluten Free
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Size: 60 Count (Pack of 1)

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From the manufacturer

Lumbrokinase helps to maintain healthier blood, lower blood viscosity and support cardiovascular health.*

In many Asian cultures, the use of earthworms in traditional medicine is quite common. Hundreds of years ago, Shizhen Li compiled the famous medical book Compendium of Material, in which the earthworm (Earth dragon) was listed as a remedy for high fever and diuretic purposes in the form of a dried powder.2 This remedy is still used in Chinese folk medicine.

To meet the high demand for more natural solutions to support one’s circulatory health, bioactive components from earthworms have been studied all around the world. Because earthworms are widely used in Asian cultures, most of the scientific research on earthworms have been originated from China, Korea and Japan. The results of these studies summarized in several articles show that earthworms' extracts contain a complex enzymatic group known as lumbrokinase that has potent fibrinolytic activity. Lumbrokinase is a group of proteolytic enzymes which are able to dissolve fibrin, a protein which is involved in the coagulation of blood clots. Lumbrokinase has been shown to be safe for oral consumption in humans.3, 4, 5 Advances in the development of molecular and cellular biology techniques have greatly helped biologists to analyze the underlying molecular basis of lumbrokinase extracts. Lumbrokinase has a thrombolytic effect that may improve blood circulation*.6, 7 It has been shown to be an effective oral supplement for improving circulatory health.*8, 9

Pharmacological And Clinical Studies:

Elevated fibrinogen level is a known risk factor that reflects a problem affecting blood flow and consequently leading to heart problems. A study was conducted to observe the efficacy of one-year oral lumbrokinase enteric-coated capsules: 192 participants in the treatment group were given 600,000 units lumbrokinase, three times a day, 30 minutes before meals, and 118 participants in the control group were given placebo capsules). After 1 year of treatment, the researchers found that in the treatment group, fibrinogen level was lower and blood flow was improved. These benefits may be related to the fact that lumbrokinase has selective affinity for fibrinogen and directly hydrolyzes fibrinogen to soluble fibrinogen degradation products improving blood and plasma viscosity. Based on the study, lumbrokinase may have an anti-platelet effect through the elevation of cAMP level and Ca2+ release.10A Japanese research team investigated the pharmacological activity of pure extracts of an earthworm, Lumbricus rubellus. They discovered that the earthworm has fibrinolytic activity that is made of six different fibrinolytic isoenzymes. These enzymes were collectively named lumbrokinase after the genus name for earthworm, Lumbricus.11 Among those isoenzymes, EFE-III-1 and III-2, had strong fibrinolytic activities, broad pH optima (pH 9-11) and displayed resistance to thermal denaturation. Further studies show that lumbrokinase has trypsin-like characteristics with high substrate specificity against fibrin, which may make it suitable as a fibrinolytic agent.12, 13, 14 These results seem to suggest that lumbrokinase could potentially be an effective oral supplement in helping maintain a healthy blood state.*

A clinical study, involving 51 participants, was conducted to investigate the anticoagulation effect and fibrinolytic activity of lumbrokinase in humans. These participants were randomly divided into treatment group (n = 31) and control group (n = 20). Among other parameters, prothrombin time (PT), fibrinogen content, tissue plasminogen activator (t-PA) activity, plasminogen activator inhibitor (PAI) activity, and D-dimer level were assayed. In the treatment group, t-PA activity and D-dimer level increased, while the content of fibrinogen decreased significantly. There were no significant changes of PT and PAI activity in both groups. The researchers concluded that lumbrokinase is beneficial in lowering fibrinogen levels*. The effect of lumbrokinase may be related to the inhibition of intrinsic coagulation pathway and the activation of fibrinolysis via an increase of t-PA activity.6

In a study conducted at Beijing Tongren Hospital, participants with high levels of fibrinogen were given lumbrokinase tablets to take orally every day for three weeks. Serum fibrinogen levels were examined before and after treatment. In comparison with the control group, serum fibrinogen in the lumbrokinase group significantly decreased two weeks after treatment. These results demonstrated lumbrokinase may lower blood viscosity. Moreover, there were no side effects related to the intake of lumbrokinase.1

A study in rats was conducted to evaluate the effects of lumbrokinase-containing earthworm powder on induced thrombotic blood clots in vivo. The powder was administered orally to rats and its fibrinolytic and antithrombotic effects were investigated. The fibrinolytic activity of plasma was increased to two-folds of the control at a dose of 0.5 g/kg/day and five times with 1 g/kg/day after 4-day administration. The antithrombotic effect was studied in an arterio-venous shunt model of rats. The weight of the blood clots decreased significantly from 43.2 mg to 32.4 mg at a dose of 0.5 g/kg/day after 8-day treatment. These results support that lumbrokinase-containing earthworm powder is valuable in maintaining healthy blood flow.*17

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Scientific References go to Doctor's Best website for more information on Lumbrokinase.

Product description

Size:60 Count (Pack of 1)

Doctor s Best Lumbrokinase is a group of highly stable fibrinolytic enzymes that have been studied and utilized extensively in China for many years. Research suggests that lumbrokinase may have beneficial effects on the cardiovascular system . Lumbrokinase is a highly active form of this enzyme group and may be used to support and maintain healthy cardiovascular function .


Product details

Size:60 Count (Pack of 1)
  • Is Discontinued By Manufacturer : No
  • Product Dimensions : 2.13 x 2.13 x 3.69 inches; 1.76 Ounces
  • Item model number : DRB-00181
  • UPC : 753950001817
  • Manufacturer : Doctor's Best
  • ASIN : B0019H1426
  • Domestic Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
  • International Shipping: This item can be shipped to select countries outside of the U.S. Learn More
  • Customer Reviews:
    4.6 out of 5 stars 173 ratings

Important information

Safety Information

Use under medical supervision if taking anti- coagulant drugs. Contraindicated with any condition association with bleeding. . This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

Ingredients

Lumbrokinase (equal to 720,000 Lumbrokinase Units) 40 mg, Maltodextrin, medium chain triglycerides, modified cellulose (vegetarian capsule).

Directions

As a dietary supplement, 1 to 2 capsules in the morning and an additional 1 to 2 capsules at bedtime, or as directed by a healthcare practitioner. Take with 8-10 oz. of water, one hour before a meal or two hours after. Store in a cool dry place.

Legal Disclaimer

* Disclaimer: Statements made, or products sold through this web site, have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.


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Directions As a dietary supplement, 1 to 2 capsules in the morning and an additional 1 to 2 capsules at bedtime, or as directed by a healthcare practitioner. Take with 8-10 oz. of water, one hour before a meal or two hours after. Store in a cool dry place. Take 1 to 3 capsules daily, away from food. Store in a cool dry place. Take 1 capsule daily with at least 8oz of water on an empty stomach, or as recommended by a nutritionally-informed physician. First time users may benefit from starting with lower dosage Serrapeptase 40,000 SPU. Adults take one (1) tablet three time a day 30-60 minutes before , or two hours after a meal. Take with an 8 Oz glass of water. Take for 2 weeks, then reduce dosage to one (1) tablet twice daily for 2 weeks. Do not exceed six (6) tablets in one day.
Safety Warning Use under medical supervision if taking anti- coagulant drugs. Contraindicated with any condition association with bleeding. . This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings KEEP OUT OF REACH OF CHILDREN. FOR ADULT USE ONLY.

CAUTION: DO NOT EXCEED RECOMMENDED DOSAGE. CONSULT A PHYSICIAN IF YOU ARE PREGNANT, NURSING, OR TAKING ANY PRESCRIPTION MEDICATIONS.

DO NOT USE IF SEAL IS BROKEN OR MISSING. This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings
Contains SoyThis product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings Store in cool, dry place. Allergen Caution: Non-GMO / Gluten Free / Vegan.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings Do not exceed recommended dose. Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before taking this or any dietary supplement. In the unlikely event that you do experience any side effects or allergies, stop use immediately and promptly seek medical attention.
Size 60 Count (Pack of 1) 180 Count (Pack of 1) 90 Count (Pack of 1) 90 Count (Pack of 1) 60 Count (Pack of 1)

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Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.