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Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

4.0 out of 5 stars 797 customer reviews
Why we love this product:
  • Low Return Rate: 21% fewer returns than similar products
  • Highly Rated: 4.0 star rating with over 700 reviews
  • Popular Item: Popular with customers shopping for "sam e"
Amazon's Choice Why we love this product

About the product
  • Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
  • SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
  • SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
  • SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years
  • Pharmaceutical grade, Non-GMO, Gluten Free, Vegan

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From the manufacturer

Product description

Size:60 count

SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.*


Product details

Size: 60 count
Data Sheet [PDF]
  • Product Dimensions: 3.2 x 2 x 6.1 inches ; 3.2 ounces
  • Shipping Weight: 4 ounces (View shipping rates and policies)
  • Domestic Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
  • International Shipping: This item is not eligible for international shipping. Learn More
  • ASIN: B004YLAXOE
  • UPC: 753950002524
  • Item model number: DRB-00252
  • Average Customer Review: 4.0 out of 5 stars 797 customer reviews
  • Amazon Best Sellers Rank: #1,026 in Health & Household (See Top 100 in Health & Household)
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Important information

Safety Warning
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Ingredients
S-Adenosyl Methioine 400 mg, Cellulose, Methacrylic Acid Copolymer, Glyceryl Behenate, Magnesium Silicate, Triethyl Citrate, Titanium Dioxide, Magnesium Stearate, Mannitol, Glycerol Palmitostearate, Silicon Dioxide, Medium Chain Triglycerides, Sodium Carboxymethl Starch and Iron Oxide.

Directions
Take 1 tablet daily between meals, or as recommended by a nutritionally-informed professional. Do not chew or crush tablet. Store in a cool dry place.

Legal Disclaimer
This price is for one 60ct pkg

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Please see our full disclaimer below.

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August 11, 2016
Size: 60 count|Verified Purchase
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Size: 60 count|Verified Purchase
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Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.