- File Size: 6207 KB
- Print Length: 316 pages
- Publisher: Avery; 1 edition (August 22, 2017)
- Publication Date: August 22, 2017
- Sold by: Penguin Group (USA) LLC
- Language: English
- ASIN: B01M28ROCU
- Text-to-Speech: Enabled
- Word Wise: Enabled
- Lending: Not Enabled
- Amazon Best Sellers Rank: #27,432 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
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The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline Kindle Edition
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From the Publisher
—Maria Shriver, Today Show
"The End of Alzheimer’s is a monumental work. Dr. Bredesen completely recontextualizes this devastating condition away from a mysterious and unsolvable process to one that is both preventable and, yes, reversible. Pinning our hopes on pharmaceutical research to develop a miraculous wonder drug has left both physicians and patients empty handed. But now, this comprehensive approach offers solid results, bringing hope to so many."
—David Perlmutter, MD, Board-certified neurologist and author, #1 New York Times bestseller, Grain Brain, and Brain Maker
"The End of Alzheimer's, for the first time, synthesizes the latest science into a practical plan that can reverse Alzheimer's and dramatically improve brain health and function. If you have a brain, read this book."
—Mark Hyman, MD, author of the #1 New York Times bestseller Eat Fat, Get Thin
"This book represents a major turning point in our approach to Alzheimer’s disease, from viewing it as a mysterious and incurable affliction that is governed almost exclusively by our genes, to understanding it as a multifactorial condition that can be prevented and even reversed largely through nutrition and lifestyle change. For the first time ever, patients and families affected by Alzheimer’s—as well as those at high risk for this devastating disease—truly have a reason to be hopeful."
—Chris Kresser, M.S., L.Ac Founder, Kresser Institute for Functional & Evolutionary Medicine, Author of the New York Times best seller The Paleo Cure
"The End of Alzheimer’s is a masterful, authoritative, and ultimately hopeful patient guide to functional medicine for your brain. It will help you prevent and reverse Alzheimer’s disease, whether you have the ApoE4 gene or not. My patients fear Alzheimer’s more than any other diagnosis. This is the book to transmute fear into action."
—Sara Gottfried, MD, New York Times bestselling author of Younger
"Having spent several years implementing many of Dr. Bredesen's insights in my patients, I can assure you that following his advice can save yourself, your loved ones, and your friends from suffering from this preventable and reversible curse."
—Steven Gundry, MD, author of the New York Times bestseller The Plant Paradox
"Dr. Dale Bredesen is a world class neuroscientist/neurologist who through his innovative and exacting research has discovered a safe and effective approach to the prevention and treatment of Alzheimer's disease that will revolutionize the way we think about the disease."
—Jeffrey Bland, PhD, FACN, FACB; President, Personalized Lifestyle Medicine Institute
"The End of Alzheimer's offers a new beginning in Medicine — changing the focus from a singular disease to recognizing the systems-based approach required to care for the whole person. Dr. Bredesen translates the knowledge of science to the wisdom that helps to heal our people . . . and provide a vision for the end of Alzheimers!"
—Patrick Hanaway, MD, Founding Medical Director, Director of Research, Center for Functional Medicine, Cleveland Clinic
"In this engaging, heartfelt, and insightful book, Dr. Bredesen elucidates a bold new approach to Alzheimer's, rooted in decades of his own pioneering research. A must read for anyone wondering what can be done for this dread disease, whether for themselves, a loved one, or a patient."
—Nathan Price, PhD, Professor & Associate Director of the Institute for Systems Biology
Excerpt. © Reprinted by permission. All rights reserved.
Kristin was suicidal. Years before, she had watched in despair as her mother’s mind slipped away, forcing her to enter a nursing home after she could no longer recognize family members, let alone care for herself. Kristin had suffered along with her mother, who at the age of 62 had begun an 18‑year decline into Alzheimer’s disease. And at the end Kristin had suffered alone, for her mother was no longer sentient.
When Kristin was 65, she began to experience her own cognitive problems. She got lost when driving on the freeway, unable to remember where to get off and on, even on familiar routes. She could no longer analyze data critical to her job, or organize and prepare reports in a timely fashion. Unable to remember numbers, she had to write down even four digits, not to mention phone numbers. She had trouble remembering what she had read, and by the time she reached the bottom of a page had to start at the top again. Reluctantly, Kristin prepared her resignation. She began to make mistakes more and more frequently, often calling her pets by the wrong names and having to search to find the light switches in her own home, even though she had flipped them on and off for years.
Like many people, Kristin tried to ignore these symptoms. But they got worse and worse. After two years of unremitting cognitive decline, she consulted her physician, who told her she was becoming demented just as her mother had, and there was nothing he could do for her. He wrote “memory problems” on her chart, and because of that, she was unable to obtain long-term care insurance. She underwent retinal scanning, which revealed the Alzheimer’s-associated amyloid. She thought about the horror of watching her mother decline, about how she would live with progressive dementia and no long-term care, about the lack of treatment. She decided to commit suicide.
She called her best friend, Barbara, explaining, “I watched what my mother went through as she slipped away, and there is no way I will allow that to happen to me.” Barbara was horrified to hear Kristin’s saga. But unlike when other friends had fallen victim to dementia, this time Barbara had an idea. She told Kristin about new research she had heard about, and suggested that rather than ending her life, Kristin travel several thousand miles to the Buck Institute for Research on Aging, just north of San Francisco. In 2012, Kristin came to see me.
We talked for hours. I could offer her no guarantee, no example of any patient who had used the protocol—nothing more than diagrams, theory, and data from transgenic mice. In reality, Barbara had been premature in sending her to the Institute. And to make matters worse, the protocol I had developed had just been turned down for its first proposed clinical trial. The review board felt that it was “too complicated,” and pointed out that such trials are meant to test only a single drug or intervention, not an entire program (ah, if only diseases were that simple!). So all I could do was to go over the various parts of the protocol and recommend that she take these to her physician back home, asking him if he would work with her. She did that, and so began what has become the ReCODE protocol.
Three months later, Kristin called me at home on a Saturday to say she could not believe the changes in her mental abilities. She was able to work full-time again, to drive without getting lost, and to remember phone numbers without difficulty. She was feeling better than she had in years. When I put the phone down, what rushed into my mind were the decades of research, the countless hours at the whiteboard with lab members and colleagues, the arguments with myself about each detail of the theory and treatment approach. All of this had not been in vain; it had pointed us in the right direction. Of course Kristin was only one person—as they say, an “n of one”— and we needed to see similar results in thousands and ultimately in millions. I thought back to the doctor who told his patient, “You are just an anecdote; you are not statistically significant.” To which his patient replied, “Well, my family says that I am significant. Besides, I’m healthy once again, so I don’t care about statistics.” Indeed. Every fundamental change needs to start somewhere—every successful approach must start with Patient Zero—and Kristin was Patient Zero. --This text refers to the audioCD edition.
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I first heard of the Bredesen Protocal last winter, when Maria Shriver discussed it on the Today Show. I quickly researched it as much as possible, but info was limited. I had a feeling a book was forthcoming, so I anxiously awaited it's release. I was worried The End of Alzheimer's would contain too much technical information that I might not be able to understand. I was very happy to see that it was written in a casual format that intentionally makes it easier for the rest of us. The details are clear, the tone is casual, and it's easy to follow.
As I read through this book, I was surprised by how many points were familiar to me. That's me! I do that! Oh heck! It was as enlightening as it was scary. Living with Mom, I also live in fear because I know I'm on the same path she struggles down every day. That's my future.
On page 97, Bredesen says "How to give yourself Alzheimer's. Live your life in a way that keeps your brain supplied with as many as possible of the 36 factors that influence whether APP gets cut into the destructive quartet or the beneficial duo. How to prevent it. Live your life in a way that minimizes the number of the 36 inducing factors in your brain." Those 36 factors are clearly laid out and I believe they are not difficult to control.
Several years ago, I struggled with brain fog and often had difficulty remembering numbers for even a couple of minutes. I also was overweight and had heart problems. I reached a point where I thought I would die, so I wrote my will and made plans for my dogs after I was gone. Then I said enough was enough, and I dramatically changed my lifestyle. I cut out processed foods, ate lots and LOTS of vegetables and fresh fruits, especially leafy greens and berries. I ate wild caught fish, but no other animal products. My diet was low in grains. I used the USDA Super Tracker to make sure that my diet exceeded the RDA for every nutrient they tracked. There's a lot more to it, but I was eating all the time and I exercised every single day. Within a few weeks, I had much more energy. Within a few months, my brain was on FIRE! But then...
I started a new job and everything about my lifestyle and schedule changed. Long story short, I fell back into old habits, abandoned my perfect diet and exercise program, and gradually regained weight. I also started losing clarity and life became more difficult. I recognize that. And I know that I alone can change that.
I'm so very glad to have read the Bredesen Protocol because I know now, more than ever, the importance of getting back on track. I am making a serious effort to change my future. I believe this book can help. I have already marked my calendar and plan to follow up on this review in 3 months and again in six months. Mom may be too far along, I don't know, but it's worth trying for both of us. Dr. Bredesen states in the book that his protocol may not work for frontal lobe and other types of dementias. It has only been tested on Alzheimers. I feel that it's still very important to heed his advice, as Alzheimers often doesn't get a definite diagnosis until after death.
Why is this an important issue? Because we have a tsunami of Alzheimer’s disease approaching on and it is on track to take the lives of 45 million of the 325 million Americans alive today. It’s currently the third leading cause of death in the US and is costing the United States over $220 billion annually. It is a trillion-dollar global health problem. It was the sixth leading cause of death
Dr. Bredesen is uniquely qualified to write this book as he has spent most of his three decades as a physician in this field and was trained at Cal Tech and Johns Hopkins. He is the director of Neurodegenerative Disease Research at the University of California, Los Angeles (UCLA) School of Medicine, He has identified a number of molecular mechanisms at work in this disease, and has created a novel program to treat and reverse it that he calls ReCODE (Reversal of Cognitive Decline)
Many are concerned about this disease and have had themselves tested for the genetic risk factor Apolipoprotein E epsilon 4 (ApoE4). An estimated 75 million Americans have the single allele for ApoE4. Those who are ApoE4 positive have a 30 percent lifetime risk of developing the disease. Approximately 7 million have two copies of the gene, which puts them at a 50 percent lifetime risk.
One of the highlights of the book is his strategy of how to actually reverse ApoE4 damage. This can be done by simply implementing intermittent fasting and restricting your eating window to 4-8 hours a day. This is because ApoE4 appears to be a gene that all ancient humans had and it provided an metabolic advantage for those that were regularly going without food and fasting for periods as was common in ancient times. Individuals that had this gene would actually live longer as they could more easily switch between fat and carb burning. This knowledge can help you actually reverse the damage that most of us acquire when we inherit this gene by merely implementing intermittent fasting.
His ReCode program discussed three dozen different tests that one can screen for and if they are abnormal they can be addressed to improve the synaptic balance to a more healthy level and reverse or radically reduce the risk of Alzheimer’s. If you ever had any concern about Alzheimer’s there is no question in my mind that this is the book to get. Strongly recommended.
Top international reviews
This is brilliantly written and easy to understand. A fantastic resource.
As well as documenting practical approaches to reversing Alzheimer's (and in so doing give hope to the millions who are already afflicted or who are genetically predisposed to the disease) Dr Bredesen explains how underlying physiological pathways converge to increase the risk of getting the disease. Dr Bredesen intersperses his narrative with testimonials of patients who have successfully reversed this truly awful soul-destroying disease.
It is evident that Dr Bredesen has faced huge obstacles in extending the reach of his programme to reverse Alzheimer's however he has been resolute in his determination to conduct further trials and to spread the message of hope that his programme, ReCODE offers to many millions of sufferers and their loved ones.
I remain convinced that Dr Bredesen's 21st Century 'programmatic' medical approach will ultimately gain world-wide acceptance not just for Alzheimer's but for other modern chronic diseases such as obesity, diabetes and cardiovascular disease.
I'd like to say thank you to Dr Bredesen and his team for their research over the past three decades because for people like me who face the horrific prospect of Alzheimer's I now have hope and a means to avoid it and live a healthier lifestyle as I age.
This is in sharp contrast to any current drugs that target Alzheimers, which can only slow the onset of the disease, not reverse it.
On a practical level, it also explains how to keep oneself at peak mental capacity.
I am a software engineer. As any software engineer gets a decade older, their chance of remaining in the profession decreases by 50%, partly as the job is too mentally taxing for someone of their age. As the lifestyle, supplements and drugs described have proven to heal a damanged brain, they can also keep a healthy brain running at optimum performance.
I, for one, will be loosely following the protocols in this book to avoid cognitive decline, and keep at peak mental performance.
Sadly the complexity means it would be very difficult for a non medical person to easily carry out the tests and necessary procedures to achieve what Dr Bredesen. But what is really tragic is that despite his successes his work is not better know. In the UK no one I have spoken to has heard of his work - and of course all the drug companies research is based on finding a quick fix one off pill. However he does provide a number of summaries in appendices which attempts to provide a simplified approach to diet and some other ways to at least reduce the likelihood of suffering the disease.
Thoroughly recommended without restraint!