A beautiful performance by James Gandolfini, who finally had an opportunity to present. a character who was actually similar to himself in so many areas. This is a character study of what are essentially ordinary people, struggling to make a real connection but suffering from an innate fear of failure - and a whisper of self destruction. There is real value in learning to not make judgments based upon initial physical attractions - and additional value in not permitting other people to influence our choices in partners. And even more value in truthful expression.
Although there was humor within the context of the complex situation(s), I wouldn't describe this as being a "comedy". To me, it was an honest portrayal of how frighteningly easy it can be for us to destroy relationships and hurt those about whom we care deeply - simply because of our own insecurities. And to cause damage to ourselves for those same reasons.
This is a film you can either consider as simple entertainment and then forget about - or you can look into the real heart of the story and possibly learn from it. I recognized parts of many of the people I have known in the characters.... and, admittedly, some parts of myself, as well.