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Environmental and Genetic Causes of Autism Hardcover – November 29, 2016


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The Environmental and Genetic Causes of Autism delves deep into the full body of past and current research to reveal how genetic predispositions and environmental factors can combine to produce the conditions autism and autism spectrum disorders (ASD).

To make this groundbreaking volume, Dr. James Lyons-Weiler combed through the past fifty years of published research on autism, exploring subjects such as genetic variation, mechanisms of neurotoxicity of metals and pesticides, and the central and combined roles of each in causing autism.

Lyons-Weiler provides a major overview of all aspects of the condition of autism, reviews changes in diagnoses and treatments, and explains how genetic information can be used to tailor effective treatments, and sometimes reversals, of the symptoms. He also presents practical forward-looking suggestions on how to design future studies to facilitate the discovery of biomarkers for autism risk and how to classify the full range of autism spectrum disorders.

Autism is considered one of the most mystifying conditions of our day, and alarmed scientists, doctors, politicians, and parents are desperately trying to understand why the condition is escalating. According to the CDC, rates in the United States have risen from an estimated one in two thousand children in 1980, to one in sixty-eight in 2012, and a new National Health Interview Survey shows a rate of one in forty-five. By the time you read this book, that number may have changed yet again.

While most autism researchers focus on either environmental or genetic causes of autism, Lyons-Weiler’s opus demonstrates that to fully understand the condition and to finally put its rate on the decrease, it is essential to pay attention to the science showing how the two classes of factors interact.
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"With over one million new cases per year, a current incidence of one in 45-68 children, and a projected incidence of one in two children within two decades, this is more than an epidemic - it is a national crisis. At this rate, our entire nation will be crippled, as eventually all of us will either be autistic or caring for one. While nearly all efforts and public pronouncements are about management and care, very few are exploring cause. The most we hear from the medical community, perhaps with a sad shrug of the shoulders, is that autism is a genetic disorder, blamed on parents and ancestors, a tragic but inevitable outcome at the genetic roulette table. They vigorously cross vaccines off the list of possible causes, and state that science has settled that question for all time (as if that were possible in science). Dr Lyons-Weiler, an impeccably-credentialed biologist, with this important book, has authoritatively dispelled this myth, and clearly explains the manifestations and environmental causes of this terrible spectrum of disorders. In so doing, he provides much-needed hope for its prevention and cure. With scientific rigor that will satisfy the strictest researcher, and accessible language that welcomes the untrained, Dr Lyons-Weiler makes a compelling case for action, steps that will change our future and avert catastrophe. If you are a parent, health professional or scientist, and care about our collective future, this is an essential book to read and take action on." Michael Gaeta DAC, MS, CDN, clinician and educator

From the Author

I offer this book as a stimulant for free and open consideration of the effects of policy based on science that is bent by the overwhelming agenda of profit.  Each individual in society has to face their individual responsibility in the debacle - not for themselves, but rather for future generations. The future of our society, and indeed that of our species may well depend on this generation's ability to identify how to bend the curve of the increases in the rate of autism, yes, but also the myriad additional conditions that fall into vague classes of autoimmunological disorders.My goal in this book was to summarize as much of the basic, translational and clinical research on autism as a collection of traits.  The result is, I hope, going to help raise the bar and improve the tone of discourse on the causes of autism.  When only part of the science is selected to support a pre-conceived notion during the formation of public policy, everyone suffers from the impoverishment of knowledge. This poverty of comprehension has profound impact on a growing number of Americans and people around the world. In keeping with my personal view that it is during the time of deepest despair that we are mathematically entitled to the largest possible amount of hope, I do hope that the knowledge I have brought forward will help drive forward key changes in research and in medical practice.

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James Lyons-Weiler
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Dr. Lyons-Weiler's books get to the very heart of the matter. He brings a lifetime of experience in biomedical research, genetics, organismal and molecular biology, and deep history into all of his works. Fact-based, hard-hitting (when necessary) and always educational, he derives his passion for writing from a desire to reduce human pain and suffering.

Born on the banks of the St. Lawrence River, Lyons-Weiler often found escape from a weary life among the books in the public library. He found the science and medical books especially appealing, and read volumes on cancer and other diseases.

This prepared him for a life in academia. He conducts research without profit motive - focused exclusively on knowledge for the sake of knowing. He believes that knowledge is power. A lifelong student and ardent educator, he strives to teach even as he learns.

And he tends to leave no stone unturned, and no questions unasked...

For his latest book, "The Environmental and Genetic Causes of Autism", he read over 2,000 peer-reviewed studies on autism. He hopes to bring personalize medicine to pediatrics.