- Series: FT Press Science
- Hardcover: 608 pages
- Publisher: FT Press; 1 edition (June 3, 2012)
- Language: English
- ISBN-10: 013259708X
- ISBN-13: 978-0132597081
- Product Dimensions: 6.4 x 1.5 x 9.3 inches
- Shipping Weight: 2 pounds (View shipping rates and policies)
- Average Customer Review: 4.5 out of 5 stars See all reviews (5 customer reviews)
- Amazon Best Sellers Rank: #1,702,770 in Books (See Top 100 in Books)
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Epigenetics in Health and Disease (FT Press Science) 1st Edition
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From the Back Cover
An Authoritative and Accessible Introduction to Epigenetics
• Emerging discoveries about the deep linkages between genetics and environment
• Understanding reversible mechanisms of heredity that do not modify DNA sequence
• From cancer to psychiatry: what bioscientists are learning about epigenetics and disease
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by Igor Kovalchuk and Olga Kovalchuk, two active researchers in the field, this book introduces key concepts one step at a time, enabling students at all levels to benefit.
After reviewing the field’s history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments.
The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, and toxicology to the development of hardier crops.
About the Author
Igor Kovalchuk, Ph.D., MD, is Professor and Board of Governors Research Chair at the Department of Biological Sciences, University of Lethbridge (Alberta, Canada). He edits Frontiers in Plant Microbe Interaction, Frontiers in Epigenomics, and other journals. As principal investigator in the university’s Plant Biotechnology laboratory, he studies genetic and epigenetic regulation of plant response to stress, including the transgenerational effects of stress and microevolution of plant stress tolerance/resistance.
Olga Kovalchuk, Ph.D., MD is Professor and Board of Governors Research Chair and CIHR Chair in Gender and Health at the University of Lethbridge and a member of the editorial boards of Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis and Environmental and Molecular Mutagenesis. She researches the role of epigenetic dysregulation in carcinogenesis; epigenetic regulation of cancer treatment responses; radiation epigenetics and role of epigenetic changes in genome stability and carcinogenesis; radiation-induced oncogenic signaling; and radiation-induced DNA damage, repair, and recombination.
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Top Customer Reviews
The authors provide a review of the chromosome and its structure and the importance of the histones in the overall expression of genes.
They then provide an excellent discussion of methylation, one of the key elements in epigenetic control. Methylation of the C element in DNA has been found to provide a broad set of changes in gene expression. The authors introduce the reader to these in a straightforward and understandable manner. As such this can be used as a good first introduction to this area.
The author then goes into non-coding RNAs including the miRNA and lncRNAs. The authors provide a broad discussion of these areas across many kingdoms, plants, animals, fungi etc. This coverage is well done and allows the reader to see how these effects impact many areas. All too often the focus may be upon the human, but seeing this in other kingdoms as well is extremely informative.
The authors conclude with several chapters on the impact of these epigenetic factors; methylation and ncRNAs. The classic set; cancer, behavioral, and environmental are discussed.The chapter on cancer and epigenetics is especially worthwhile. It covers a wide range but at a readily accessible level.
On the positive side the authors have kept the level of presentation understandable and consistent. The level and depth is adequate for a good initial introduction to the literature. The book is not an in depth reference text but then again there is none that I am aware of. In addition the knowledge in this field is changing on an almost daily basis.
I would strongly recommend this book to anyone wanting to take the first steps into this exciting area.
There are some additions that I would like to have seen:
1. In the cancer area, the Myelodysplastic Syndrome, MDS, is an interesting hypermethylation pre-cancer often resulting in AML. It is treated with drugs targeting this hypermethylation. I believe that this would be an excellent case study for many cancers. In addition there is the cause or effect element regarding the methylation states of many cancers. This is still a work in progress.
2. Flower colors and patterning is an interesting area for the use of epigenetic analysis. I would like to see some discussion here. For example is there a relationship to the X chromosome issue as in calico cats or is this a pathway control issue often found in other patterning areas.
3. Figures can be dramatically improved. The black and white ones are barely readable and the colored versions are in the rear of the text and are not of great quality. The figure lend a great deal.
4. Agouti mouse issues regarding a way to measure methylation effects may be a useful tool and should be considered for inclusion. Just a thought
Overall the authors have done a superb job and the book is worth being on the shelf of all involved in this area.