& FREE Returns
Return this item for free
  • Free returns are available for the shipping address you chose. You can return the item for any reason in new and unused condition: no shipping charges
  • Learn more about free returns.
FREE delivery Friday, August 19
Or fastest delivery Wednesday, August 17. Order within 1 hr 2 mins
In Stock.
[{"displayPrice":"$59.98","priceAmount":59.98,"currencySymbol":"$","integerValue":"59","decimalSeparator":".","fractionalValue":"98","symbolPosition":"left","hasSpace":false,"showFractionalPartIfEmpty":true,"offerListingId":"UmVZ4QdxDkhvImvWl2NnP9yG5ZsdXIfSsgbxIwIcvMDIbiqE6DcVBNjGN6xHF1kd2KxfBExhuH2IOp%2FCf0%2F2W8KqG1M%2FxInitM0n%2F7%2BURGo0K42NNJqgZRYZwg3buzwZsCybkjj3fVG%2BLLr8Au%2BUSA%3D%3D","locale":"en-US","buyingOptionType":"NEW"},{"displayPrice":"$56.98","priceAmount":56.98,"currencySymbol":"$","integerValue":"56","decimalSeparator":".","fractionalValue":"98","symbolPosition":"left","hasSpace":false,"showFractionalPartIfEmpty":true,"offerListingId":null,"locale":"en-US","buyingOptionType":"SNS"}]
$$59.98 () Includes selected options. Includes initial monthly payment and selected options. Details
Price
Subtotal
$$59.98
Subtotal
Initial payment breakdown
Shipping cost, delivery date, and order total (including tax) shown at checkout.
Your transaction is secure
We work hard to protect your security and privacy. Our payment security system encrypts your information during transmission. We don’t share your credit card details with third-party sellers, and we don’t sell your information to others. Learn more
Ships from
Amazon.com
Sold by
Amazon.com
Ships from
Amazon.com
Sold by
Amazon.com
Return policy: Eligible for Return, Refund or Replacement within 30 days of receipt
This item can be returned in its original condition for a full refund or replacement within 30 days of receipt.
Advantage II Flea Prevent... has been added to your Cart
Save 5% on all deliveries.

Unlock extra savings

Receive 5 or more products in one auto-delivery to one address and unlock extra savings on all eligible products.

Choose how often it's delivered

From once every 2 weeks to once every 6 months

Skip or cancel any time

We'll send you a reminder before each delivery.
Learn more
Get it Friday, Aug 19
In Stock.
Deliver every:
[{"displayPrice":"$59.98","priceAmount":59.98,"currencySymbol":"$","integerValue":"59","decimalSeparator":".","fractionalValue":"98","symbolPosition":"left","hasSpace":false,"showFractionalPartIfEmpty":true,"offerListingId":"UmVZ4QdxDkhvImvWl2NnP9yG5ZsdXIfSsgbxIwIcvMDIbiqE6DcVBNjGN6xHF1kd2KxfBExhuH2IOp%2FCf0%2F2W8KqG1M%2FxInitM0n%2F7%2BURGo0K42NNJqgZRYZwg3buzwZsCybkjj3fVG%2BLLr8Au%2BUSA%3D%3D","locale":"en-US","buyingOptionType":"NEW"},{"displayPrice":"$56.98","priceAmount":56.98,"currencySymbol":"$","integerValue":"56","decimalSeparator":".","fractionalValue":"98","symbolPosition":"left","hasSpace":false,"showFractionalPartIfEmpty":true,"offerListingId":null,"locale":"en-US","buyingOptionType":"SNS"}]
$$59.98 () Includes selected options. Includes initial monthly payment and selected options. Details
Price
Subtotal
$$59.98
Subtotal
Initial payment breakdown
Shipping cost, delivery date, and order total (including tax) shown at checkout.
Ships from and sold by Amazon.com
Other Sellers on Amazon
Added
$59.98
& FREE Shipping. Details
Sold by: Pets Go Here - Pet Store
Sold by: Pets Go Here - Pet Store
(13408 ratings)
98% positive over last 12 months
In Stock.
Shipping rates and Return policy
Added
$59.98
& FREE Shipping
Sold by: EntirelyPets
Sold by: EntirelyPets
(352646 ratings)
94% positive over last 12 months
In Stock.
Shipping rates and Return policy
Added
$59.98
& FREE Shipping
Sold by: PetStoreUSA
Sold by: PetStoreUSA
(210 ratings)
96% positive over last 12 months
Only 3 left in stock - order soon.
Shipping rates and Return policy
Have one to sell?

Advantage II Flea Prevention and Treatment for Large Dogs (21-55 Pounds)

4.5 out of 5 stars 3,448 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Advantage

Price: $56.98 $56.98
6-Pack

Enhance your purchase

Brand Advantage
Item Form Other
Age Range Description Senior
Item Weight 0.1 Pounds
Active Ingredients Imidacloprid
Target Species Dog

About this item

  • 6-dose large dog flea prevention, topical flea treatment for large dogs weighing 21-55 pounds
  • Easy-to-apply and pre-measured application tubes, fragrance-free and designed specifically to treat and prevent fleas on dogs
  • Advantage II large dog flea treatment kills fleas through contact, meaning fleas don’t have to bite your dog in order to die
  • Starts working within 12 hours and protects your dog for up to 30 days
  • Vet-recommended, fragrance-free and designed specifically to treat and prevent fleas and lice on dogs

Customer ratings by feature

Easy to use
4.1 4.1
Scent
3.9 3.9
Value for money
3.4 3.4

Every BarkBox includes original toys and healthy treats, and features a new theme every month to keep your dog happy. Find out why millions of dogs love BarkBox. Every BarkBox includes original toys and healthy treats, and features a new theme every month to keep your dog happy. Find out why millions of dogs love BarkBox.

Frequently bought together

  • Advantage II Flea Prevention and Treatment for Large Dogs (21-55 Pounds)
  • +
  • Advantage II Flea Prevention and Treatment for Large Cats (Over 9 Pounds)
  • +
  • Advantage II Flea Prevention and Treatment for Medium Dogs (11-20 Pounds)
Total price:
To see our price, add these items to your cart.
Choose items to buy together.

From the manufacturer

Dog flea lifecycle
Advantage Seresto Advantix advantus advantage
Advantage II​ Seresto​ K9 Advantix II advantus ​ Advantage ​Dog Shampoo
Form Topical Flea Treatment Flea and Tick Collar Topical Flea, Tick and Mosquito Treatment Flea Soft Chew Flea and Tick Shampoo
Application Age For Use on Dogs and Puppies 7 Weeks and Older For Use on Dogs and Puppies 7 Weeks and Older For Use on Dogs and Puppies 7 Weeks and Older For Dogs 10 Weeks of Age and Older For Use on Dogs Over 12 Weeks Old
Application Frequency Once a Month Every 8 Months Once a Month Do Not Exceed One Soft Chew in a 24-hour Period See Product Label
Kills Fleas
Kills Ticks
Kills Lice
Kills Mosquitoes

Product Description

Product Description

Advantage II topical flea and lice treatment for large dogs weighing 21 to 55 pounds is a vet-recommended monthly application that kills fleas through contact, so they don't have to bite your dog to die. Even indoor dogs need flea protection because humans and other pets can bring fleas into your home. The protection of Advantage II kills fleas in multiple life stages, including eggs, larvae and adults, effectively breaking the flea life cycle to prevent flea infestation on your dog. This 6-dose dog flea treatment comes in a convenient topical liquid that is easy to apply, fragrance-free and waterproof after 24 hours. A single application of Advantage II flea treatment for dogs starts working in 12 hours and keeps killing fleas for 30 days. Advantage II flea control for dogs is available in packs of four or six monthly applications for dogs of all sizes. Advantage II is also available in a formula for cats. Fight the misery of biting fleas with the help of Advantage II 6-dose flea and lice treatment for large dogs.

Brand Story

By Advantage

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 6.5 x 1 x 4.25 inches; 1.6 Ounces
  • Item model number ‏ : ‎ 86336685
  • Department ‏ : ‎ Flea & Tick
  • Date First Available ‏ : ‎ December 20, 2002
  • Manufacturer ‏ : ‎ Elanco US Inc
  • ASIN ‏ : ‎ B004QMX59Q
  • Country of Origin ‏ : ‎ Germany
  • Customer Reviews:
    4.5 out of 5 stars 3,448 ratings

Product guides and documents

Important information

Safety Information

N/A

Ingredients

Imidacloprid, Pyriproxyfen

Directions

Application Instructions: 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. 5. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. 6. Do not apply an excessive amount of solution at any one spot that could cause the solution to run off the side of the dog. 7. Do not get this product in your dog’s eyes or allow them to ingest.

Legal Disclaimer

returns accepted

Compare with similar items


Advantage II Flea Prevention and Treatment for Large Dogs (21-55 Pounds)
Advantage II Flea Prevention and Treatment for Medium Dogs (11-20 Pounds)
Advantage II Flea Prevention and Treatment for Small Dogs (3-10 Pounds)
Bayer Animal Health Advantage II Extra Large Dog 4-Pack
Amazon Brand - Solimo Flea and Tick Treatment for Dogs, 3 Count
Bayer Animal Health Advantage II Extra Large Dog 6-Pack
Customer Rating 4.5 out of 5 stars (3448) 4.5 out of 5 stars (3853) 4.5 out of 5 stars (3453) 4.6 out of 5 stars (555) 4.1 out of 5 stars (18019) 4.6 out of 5 stars (322)
Price $59.98 $59.98 $44.98 $59.94 $23.20 $59.98
Shipping FREE Shipping. Details FREE Shipping. Details FREE Shipping. Details FREE Shipping. Details FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime FREE Shipping. Details
Sold By Amazon.com Amazon.com Amazon.com Pets Go Here - Pet Store Amazon.com Pets Go Here - Pet Store
Active Ingredients Imidacloprid Imidacloprid 9.10% Pyriproxyfen 0.46%
Age Range Description Senior All Life Stages All Life Stages Extra Large Dogs All ages
Brand Name Advantage Advantage Advantage Bayer Animal Health Solimo Bayer Animal Health
Item Form other other other
Item Weight 1.60 ounces 1.60 ounces 0.16 ounces 1.60 ounces 2.40 ounces
Target Species dog Dog Dog Dog Dogs Dog

Customer questions & answers

See questions and answers

Customer reviews

4.5 out of 5 stars
4.5 out of 5
3,448 global ratings

Top reviews from the United States

Reviewed in the United States on February 5, 2022
Size: 4-PackVerified Purchase
3 people found this helpful
Report abuse
Reviewed in the United States on May 19, 2021
Size: 6-PackVerified Purchase
2 people found this helpful
Report abuse
Reviewed in the United States on January 9, 2016
Size: 4-PackVerified Purchase
15 people found this helpful
Report abuse
Reviewed in the United States on February 18, 2022
Size: 6-PackVerified Purchase
One person found this helpful
Report abuse
Reviewed in the United States on January 13, 2021
Size: 6-PackVerified Purchase
One person found this helpful
Report abuse
Reviewed in the United States on November 20, 2014
Size: 6-PackVerified Purchase
2 people found this helpful
Report abuse