- Hardcover: 336 pages
- Publisher: St. Martin's Press; 1 edition (March 13, 2012)
- Language: English
- ISBN-10: 0312681909
- ISBN-13: 978-0312681906
- Product Dimensions: 6 x 1.4 x 8.4 inches
- Shipping Weight: 14.4 ounces
- Average Customer Review: 44 customer reviews
- Amazon Best Sellers Rank: #1,349,704 in Books (See Top 100 in Books)
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The Forever Fix: Gene Therapy and the Boy Who Saved It 1st Edition
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“In this impressive, meticulously researched study of the exciting new developments in gene therapy, geneticist and journalist Lewis (Human Genetics) looks closely at the history of setbacks plaguing the treatment of rare genetic diseases as well as recent breakthroughs...Yet with each success, as Lewis recounts in this rigorous, energetic work, possibilities in treating HIV infection and dozens of other diseases might be around the next corner.” ―Publisher's Weekly (starred review)
“A fascinating account of groundbreaking science and the people who make it possible.” ―Kirkus
“Ricki Lewis gives us the inspiring story of gene therapy as told through Corey's eyes--literally. Her book delves into the challenges modern medicine faces--both in its bitter disappointments and great successes--but it goes much deeper than that. With empathy and grace, Lewis shows us the unimaginable strength of parents with sick children and the untiring devotion of the physicians who work to find ‘the forever fix' to save them. But best of all Lewis gives us a story of profound hope.” ―Molly Caldwell Crosby, author of The American Plague: The Untold Story of Yellow Fever, the Epidemic that Shaped Our History and Asleep: The Forgotten Epidemic that Remains One of Medicine's Greatest Mysteries
“The Forever Fix is a wonderful story told by one of our most gifted science and medical writers. In the tradition of Siddhartha Mukherjee's The Emperor of All Maladies, Ricki Lewis explains complex biological processes in extremely understandable ways, ultimately providing crucial insights into the modeling of disease and illustrating how gene therapy can treat and even potentially cure the most challenging of our health conditions.” ―Dennis A. Steindler, Ph.D., former Executive Director of the McKnight Brain Institute, University of Florida
“Ricki Lewis has written a remarkable book that vividly captures the breathtaking highs and devastating lows of gene therapy over the past decade while giving ample voice to all sides -- the brave patient volunteers, their parents and physicians. The Forever Fix is required reading as we dare to dream of curing a host of genetic diseases.” ―Kevin Davies, Founding editor of Nature Genetics; author of The $1,000 Genome and Cracking the Genome
“In 'The Forever Fix,' Ms. Lewis chronicles gene therapy's climb toward the Peak of Inflated Expectations over the course of the 1990s. A geneticist and the author of a widely used textbook, she demonstrates a mastery of the history.” ―The Wall Street Journal
“An engaging and accessible look at gene therapy.” ―Times Union
“Medical writer Ricki Lewis interweaves science, the history of medical trial and error, and human stories … from the death in 1999 of teenager Jesse Gelsinger, from a reaction to gene therapy intended to combat his liver disease, to radical successes in some children with adenosine deaminase deficiency. ” ―Nature
“Lewis adeptly traverses the highs and lows of gene therapy and explores its past, present, and future through the tales of those who've tested its validity.” ―The Scientist
About the Author
RICKI LEWIS is a Ph.D. geneticist, journalist, professor and genetic counselor. The author of one of the most widely used college textbooks in the field (Human Genetics: Concepts and Applications, now in its 10th edition), she has also written hundreds of popular pieces on science and other topics for trade and specialized magazines, including Nature, Discover, and The Scientist.
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Top customer reviews
Most recently, after an aborted educational start in the field of natural medicine, I've come to the conclusion that -- aside from a much-needed nutritional revolution, the other half of what simply must happen in order to advance a TRUE health improvement revolution -- we simply must attack those intractable problems of human health for which dietary and nutritional changes simply would either not be reasonably sustainable, or at all sufficient.
Much to the enraged chagrin of the Rockefellerian petro-pharmaceutical mafia that has ruled human health since the very late 1800's, we must find a way to actually repair maladaptive genes themselves and finally break the shackles of undue drug dependency once and for all.
With all that said, I was delighted to find Ricki Lewis' book. She, perhaps alone, truly gets it. She truly understands that the nature of the problem is, as she so rightly puts it, "science for science's sake", rather than for the sake of the greater human race who sincerely needs what would otherwise be its civilizing fruits. Dr. Lewis has written a book that, to my knowledge, is singular of kind: it really gives a damn about the good, and shows us clearly and plainly how we may not only get there, but how we have already begun to get there -- to lasting and humane fixes rather than deliberately temporary and purely profiteering temporary band-aids.
The Forever Fix delves into other stories of gene therapy--including the epic failure that was the Jesse Gelsinger case--and provides a comprehensive view of how far the technology has come in the past few decades. This would have been an ideal book to read in some of my undergrad biotech/ human genetics courses. Given the multiple distractions of the Text Messaging/ Facebook era that we live in today, Ricki's approach of jumping from story to explanation, from anecdote to story, is refreshing and keeps readers engaged.
I currently work in the biopharma industry and would also recommend this book to professionals looking to ramp up on gene therapy, as this is surely not the last we will hear of the groundbreaking technology.