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The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology Hardcover – February 15, 2022
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Named one of The New Yorker's BEST BOOKS OF 2022 SO FAR
The next frontier in technology is inside our own bodies.
Synthetic biology will revolutionize how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. This fast-growing field—which uses computers to modify or rewrite genetic code—has created revolutionary, groundbreaking solutions such as the mRNA COVID vaccines, IVF, and lab-grown hamburger that tastes like the real thing. It gives us options to deal with existential threats: climate change, food insecurity, and access to fuel.
But there are significant risks.
Who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? What cyber-biological risks are looming? Could a future biological war, using engineered organisms, cause a mass extinction event?
Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.
- Print length368 pages
- LanguageEnglish
- PublisherPublicAffairs
- Publication dateFebruary 15, 2022
- Dimensions6.4 x 1.55 x 9.6 inches
- ISBN-101541797914
- ISBN-13978-1541797918
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From the Publisher
WHAT YOU'LL LEARN
- How soon (years? decades?) you'll be able to control your own genetic destiny
- Whether humans will start to live ultra-long lives, and the impact that could have on society
- That the freshest sushi on the planet might soon be grown in a Nebraska lab
- That cells can be programmed, much like computers
- And that viruses aren't necessarily bad –– they're just containers for genetic code
- How investments will shape the bioeconomy as it is being formed
- Which companies could be the biggest winners
- The fascinating story of Golden Rice, and how misinformation killed a once-promising food source
Plus five provocative short stories exploring different futures: a restaurant review from the year 2037, a brochure from a fertility clinic, an FBI memo describing the aftermath of a deadly pathogen and a lab leak, a Chicago Cubs team that never retires, and a global Mars colonization movement inspired by Elon Musk that doesn't turn out as planned.
Editorial Reviews
Review
“[A] road map for navigating [synthetic biology’s] opportunities and perils.”―The New Yorker
“The book is a brilliant narrative of the future of human life. Webb and Hessel explain the complex matter in such a way that experts and laypeople alike can follow, whose biology lessons were a while ago.”―Handelsblatt
“[A] thought-provoking introduction to synthetic biology…[a] breathtaking science, but it is also scary. Who's in charge, and where are the brakes?”―Booklist
“[D]eeply researched but accessible prose… A wrinkle on the near future that many readers will not have pondered—and should.”―Kirkus
“The Genesis Machine is a brilliant pairing of two visionaries who offer us a comprehensive take on making a better world through biology.”―Jane Metcalfe, cofounder of Wired and CEO of NEO.LIFE
“The Genesis Machine is a very readable story about how the DNA world is shifting from reading the genetic code to writing and editing it. Amy Webb and Andrew Hessel then take the reader on a journey of possible world changing events that could result from this new technology.”―J. Craig Venter, PhD, author of Life at the Speed of Life: From the Double Helix to the Dawn of Digital and CEO of JCVI
“This spectacular and highly accessiblebook clearly and thoughtfully examines the most important revolution of our lives––and of life itself. Understanding how we and future generations will use the tools of synthetic biology to transform the worlds inside and around us is essential to being an informed and empowered person and citizen in the twenty-first century. The Genesis Machine is a guide to exactly that and a must-read book.”―Jamie Metzl, member of WHO expert committee on human genome editing and author of Hacking Darwin: Genetic Engineering and the Future of Humanity
“You may not realize it yet, but your life—and all of life itself—is about to change. From programmable genes to designer medicines, synthetic biology is going to transform everything. The Genesis Machine is a surprisingly intimate, incisive, and readable guide to the opportunities, risks, and moral dilemmas of the brave new world ahead.”―Steven Strogatz, Cornell University, author of Infinite Powers
“The Genesis Machine is a tour de force! Amy Webb and Andrew Hessel masterfully reveal the emerging network of forces—people, labs, computer systems, government agencies, and businesses—that will drive humanity’s next great transformation. Their fascinating (and frightening) conclusions—that the human ecosystem can actually become programmed—will touch every facet of our lives in the future. This brilliant work is an absolute must-read for national security professionals and defense planners who need to understand the complex dynamics at play in the future competition for bio-hegemony.”―Dr. Jake Sotiriadis, chief futurist, United States Air Force
“We can now program biological systems like we program computers, with artificial intelligence and machine learning accelerating the speed of innovation and applications of synthetic biology. In an accessible and fascinating narrative, The Genesis Machine lays out a roadmap for this interdisciplinary field of synthetic biology that is forever reshaping life as we know it.”―Rana el Kaliouby, author of Girl Decoded: A Scientist’s Quest to Reclaim Our Humanity by Bringing Emotional Intelligence to Technology and deputy CEO, Smart Eye
“Are latest innovations in synthetic biology simply a miracle that ends a crisis or a breakthrough to an entirely new way of living? That’s the question futurist Amy Webb and microbiologist Andrew Hessel reveal for us with this fascinating book. The history of the world is a history of unintended consequences, for better and for worse, and Webb and Hessel capture the coming fusion of tech and biology in vivid detail.”―Ian Bremmer, author of Collision Course
“The Genesis Machine is fantastic, explaining how genetic code is the alphabet in which much of the future will be written. Amy Webb and Andrew Hessel have taken the very complicated subject of synthetic biology and made it understandable with sharp prose and sharp analysis that cut through mysteries of science and twenty-first-century humanism.”―Alec Ross, author of The Industries of the Future and The Raging 2020s
About the Author
Andrew Hessel, a pioneer and an expert in the field of synthetic biology, is the president of Humane Genomics, an early-stage company developing synthetic viruses for canine and human oncology. He is also the co-founder and chairman of the Center of Excellence for Engineering Biology and the Genome Project, the international scientific effort to engineer large genomes, including the human genome. He is a former distinguished research scientist at Autodesk Life Sciences.
Product details
- Publisher : PublicAffairs (February 15, 2022)
- Language : English
- Hardcover : 368 pages
- ISBN-10 : 1541797914
- ISBN-13 : 978-1541797918
- Item Weight : 1.28 pounds
- Dimensions : 6.4 x 1.55 x 9.6 inches
- Best Sellers Rank: #89,012 in Books (See Top 100 in Books)
- #6 in Biomedical Engineering
- #22 in Molecular Biology (Books)
- #79 in Genetics (Books)
- Customer Reviews:
About the author

Futurist Amy Webb advises CEOs of the world’s most-admired companies, studio heads and showrunners, three-star admirals and generals, and the executive leadership of banks and intergovernmental organizations. Founder and CEO of the Future Today Institute, a leading foresight and strategy firm that helps leaders and their organizations prepare for complex futures, Amy pioneered a data-driven, technology-led foresight methodology that is now used within hundreds of organizations globally. She is a professor of strategic foresight at the NYU Stern School of Business, where she developed and teaches the MBA course on strategic foresight and a Visiting Fellow at Oxford University’s Säid School of Business. She was elected a life member to the Council on Foreign Relations and is a member of the World Economic Forum where she serves on a Global Future Council and Stewardship Board. A lifelong science fiction fan, Amy collaborates closely with Hollywood writers and producers on films, TV shows and commercials about science, technology and the future. She is a member of the Academy of Television Arts & Sciences and has served as a Blue Ribbon Emmy award judge. She is the author of several popular books, including The Big Nine: How the Tech Titans and Their Thinking Machines Could Warp Humanity, which was longlisted for the Financial Times & McKinsey Business Book of the Year award, shortlisted for the Thinkers50 Digital Thinking Award, and won the 2020 Gold Axiom Medal for the best book about business and technology, and The Signals Are Talking: Why Today’s Fringe Is Tomorrow’s Mainstream, which won the Thinkers50 Radar Award, was selected as one of Fast Company’s Best Books of 2016, Amazon’s best books 2016, and was the recipient of the 2017 Gold Axiom Medal for the best book about business and technology. Webb was named by Forbes as one of the five women changing the world, listed as the BBC’s 100 Women of 2020, ranked on the Thinkers50 list of the 50 most influential management thinkers globally. Her latest book, The Genesis Machine, explores the futures of synthetic biology.
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One comment should be made about Webb's tone of voice in this book, which seems to have changed from her previous works. I am in love with Walter Isaacson. I think his books, without exception, are incredibly informative, right on the mark, and he has a unique voice.
Webb seems to have adopted Isaacson's method of story-telling in this book. I think that is a positive addition. After I finished her introduction about her miscarriage, though it was personal (and Isaacson never gets personal), it still was like reading Isaacson. That is a significant compliment.
TBH, before this, I had never heard of the co-author, Andrew Hessel, and if he was the only name on the book, I doubt I would have given it any thought or bought it. However, his writing is also excellent and certainly worthy of a read.
A pure pleasure. Incredibly informative. And folks, you do not have to accept every single premise of the authors, nor do you have to agree with their conclusions. They may be correct, but they may not be valid. There is still no reason to take issue with this book's thoughts, premises, and conclusions, nor with the clarity in which it was written.
It is a must-read for those in AI, genetics, or just those who want to know where everything is heading. Indeed, there is a great deal of food for thought here.
Synthetic biology is somewhat well known, however, the vast majority of the world is still largely ignorant about this science and what it is capable of and what it likely will be capable of. When the world knows, there will be a great divide, possibly the greatest divide within human in history, more than any philosophy, ideology or religion could ever cause, with those who say yes and those who say no.
As the title of this reviews states - it's all over the place, kind of the shotgun approach.
Finally, imagine my surprise (and yours) when the book ends at 74%! Yeah, that's right. 26% of this book is footnotes.
It disabuses the negative views of GMO foods, and also mourns the lack of minority genetic dna sequencing.
Top reviews from other countries
Very disappointing.
Reviewed in Canada 🇨🇦 on February 25, 2022









