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Genetic Entropy Paperback – November 7, 2014
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Dr. Sanford's findings have enormous implications. His work largely invalidates classic neo-Darwinian theory. The mutation/selection process by itself is not capable of creating the new biological information that is required for creating new life forms. Dr. Sanford shows that not only is mutation/selection incapable of creating our genomes - it can't even preserve our genomes. As biochemist Dr. Michael Behe of Lehigh University writes in his review of Genetic Entropy, "...not only does Darwinism not have answers for how information got into the genome, it doesn't even have answers for how it could remain there." Dr. Sanford has coined the term "genetic entropy" to describe this fatal flaw of neo-Darwinian theory. This fundamental problem has been something of a trade-secret within the field of population genetics, with the rest of the world largely being kept in the dark. Fortunately, this book finally discloses this very serious problem, using language that is for the most part accessible to all scholars and students having a basic understanding of biology.
This new edition of Genetic Entropy includes numerous new lines of evidence supporting Dr. Sanford's thesis. Much of this new evidence is from recently published scientific papers that are now part of the scientific literature. Genetic Entropy is a must-read for any thoughtful person who in interested in science.
Dr. Sanford ends his book by asking two questions. First, if our genome did not actually arise via the accumulation of genetic "word-processing errors" (as is claimed), how did it arise? Second, if our genomes are undergoing relentless degeneration - where can we possibly place our hope for the future?
- Print length270 pages
- LanguageEnglish
- PublisherFMS Publications
- Publication dateNovember 7, 2014
- Dimensions6.1 x 0.6 x 9.1 inches
- ISBN-100981631606
- ISBN-13978-0981631608
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About the Author
At Cornell, John bred new crop varieties using conventional breeding and then became heavily involved in the newly-emerging field of plant genetic engineering. John has published over 100 scientific publications and has been granted several dozen patents. His most significant scientific contributions during the first half of his career involved three inventions: the biolistic ("gene gun") process, pathogen-derived resistance, and genetic immunization. A large fraction of the transgenic crops (in terms of numbers and acreage) grown in the world today were genetically engineered using the gene gun technology developed by John and his collaborators. John also started two biotech enterprises derived from his research, Biolistics, Inc., and Sanford Scientific, Inc.
John still holds a position at Cornell (Courtesy Associate Professor), but has largely retired from Cornell and has started a small non-profit organization, Feed My Sheep Foundation (FMS). Through FMS, John has conducted research in the areas of theoretical genetics and bioinformatics for the last 14 years. This book was the "first fruits" of those efforts.
Product details
- Publisher : FMS Publications
- Publication date : November 7, 2014
- Edition : 4th
- Language : English
- Print length : 270 pages
- ISBN-10 : 0981631606
- ISBN-13 : 978-0981631608
- Item Weight : 13.6 ounces
- Dimensions : 6.1 x 0.6 x 9.1 inches
- Best Sellers Rank: #156,971 in Books (See Top 100 in Books)
- #74 in Genetics (Books)
- #960 in Biology of Animals
- Customer Reviews:
About the authors

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Dr. John Sanford has been a Cornell University Professor for more than 30 years. He received his PhD from the University of Wisconsin in the area of plant breeding and plant genetics. While a professor at Cornell, John trained graduate students and conducted genetic research at the New York State Agricultural Experiment Station in Geneva, NY.
At Cornell, John bred new crop varieties using conventional breeding and then became heavily involved in the newly-emerging field of plant genetic engineering. John has published over 100 scientific publications and has been granted several dozen patents. His most significant scientific contributions during the first half of his career involved three inventions: the biolistic ("gene gun") process, pathogen-derived resistance, and genetic immunization. A large fraction of the transgenic crops (in terms of numbers and acreage) grown in the world today were genetically engineered using the gene gun technology developed by John and his collaborators. John also started two biotech enterprises derived from his research, Biolistics, Inc., and Sanford Scientific, Inc.
John still holds a position at Cornell (Courtesy Associate Professor), but has largely retired from Cornell and has started a small non-profit organization, Feed My Sheep Foundation (FMS). Through FMS, John has conducted research in the areas of theoretical genetics and bioinformatics for the last 14 years. With a qualified team of researchers, John produced a state-of-the-art numerical simulation program called Mendel’s Account. Mendel’s Account is the first comprehensive, biologically realistic numerical simulation of the mutation/selection process. This program tracks mutations as they accumulate in digital populations in a biologically realistic manner. It is an essential tool for understanding the limits of the Darwinian process. Mendel’s Accountant can be freely downloaded at MendelsAccountant.info. John is also working with Ratio Christi (ratiochristi.org/), where he is involved in Christian apologetics. John is also President of Logos Research Associates (see http://www.logosresearchassociates.org/). John’s scientific publications are listed at http://hort.cals.cornell.edu/people/john-sanford.
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- Reviewed in the United States on June 30, 2011The book was written for lay people, with simple pictures and analogies, but the scientific argument presented is extremely compelling and extremely relevant to medicine, health policies, and the design-vs-evolution debate.
Our genome is breaking down constantly, and the negative mutations are piling up faster than the positive ones. No known mechanisms of natural selection are sufficient to change this trend. This implies the falseness of the neodarwinist idea that our genome gradually arose over millions of years of random mutations and natural selection. Other proposed mechanisms such as endosymbiosis, gene duplication, synergistic epistasis, etc do not seem able to address the main problem of the degenerating genome, measured in the lab.
The hypothesis of the book continues to be confirmed by the latest scientific research. For example, the Wellcome
Trust Sanger Institute's recent whole-genome study measured approximately 60 new genetic mutations per generation (Nature Genetics, [...]). Two recent papers in Science show that antagonistic epistasis is far more common than synergistic epistasis, meaning that multiple mutations tend to cancel out any beneficial effect of each one individually and leading to "diminishing returns" ([...]).
On the whole, Sanford's book is well worth reading. It demonstrates yet another fatal flaw in the neodarwinian theory of evolution.
- Reviewed in the United States on June 24, 2010Note: I seem to have an earlier edition, 2005, of this book.
This book gives no indication of the author's religious views, save for a one line reference to 'design' in the last pages of the text. The rest of the book is a cogent expose of the Neo-Darwinian scenario of random mutation and natural selection.
I have reasonable math talents, and can follow more or less the models proposed by population geneticists, but the whole subject leaves one ill at ease, as one smell's a rat somewhere. All this math is deceptive, it doesn't amount to much of anything by the standards of physics. In fact, the subject is a fraud used to mesmerize the math gullible.
This book helped me out on this point, and has a lot of good commentary on population genetics and its limits. It is disconcerting to have to turn to religious critics writing self-published books to get some decent commentary on the math in population genetics.
Good fast read, and to the point. The issue of the genome is left for what it is, a mystery. Close to the end of the book the author quietly mutters the word 'design' with respect to the enigma of genomics, and the book ends. Important reading for mainstream students of evolution who have been snowjobbed by population genetics.
The book adds to the disgrace of the Neo-Darwinism synthesis.
You would think all those nerdy scientists and profs in all those peer reviewed sci orgs could spot the problems with population genetics and make them known to the public.
No such luck.
Job for a Bible Belt author, I guess.
- Reviewed in the United States on January 4, 2009In my time studying genetics, the claims of evolution have never seemed possible. There are so many things that have to occur to create a protein (even more if you want a functioning protein), and there are so many things that can go wrong in protein manufacturing within a cell. So, when I saw Dr. Sanford's book, I had to give it a read to see what he had to say.
Stanford makes a superb case for genetic degradation rather than forward evolution. The author takes Kimura's, and many other noted geneticists' data (he cites Science, Nature and dozens of other peer-reviewed pubs) and instead of sweeping the data under the rug like population geneticists do (see Scientific American here for an example of this:[...] , he takes the data and applies it to evolution. (*Sanford uses more scholarly journals than the popular Sci Amer. I post that simply as a free means to view how population geneticists see the problems and then sweep it.)
Until looking up some of the sources, I was a little worried that Sanford was not making enough of a case for his initial claims. However, after looking at the sources, Sanford is working from widely held experiments. His changes come later in the application of the data. I will say that looking at the application of the data by evolutionary biologists and looking at Sanford's application, Sanford wins the logic test hands down. The only thing he lacks that the scientists he references is that Sanford is not blindly obedient to the Primary Axiom (the idea that mutation and natural selection drives speciation in evolution.) He simply takes that data logically and notes how the data contradicts the postulations of evolution.
Much of the data Sanford refers to varies slightly from publication to publication, but when he takes the data, he views it in two ways. First, he gives every advantage to evolution when going through the data, and shows how it is impossible for evolution to occur in those situations. Then he proceeds to look at the data from the most commonly held numerical value, and further degrades the chances of evolution to occur.
He deals a lot with probability, but not to an extent that a person unfamiliar with statistics can understand. Sanford uses down to earth analogies for what he postulates, and then goes on to state in more scientific terms the facts he is trying to convey from the analogy.
One does not have to have a firm grasp on genetics or evolution to read this text, but it would help you get more out of the book if you do. There is a glossary in the back, and only on tangential topics does he refer to a term that is not clearly defined for those not trained in biology.
Sanford takes on the tough data without sweeping it under the rug like the population geneticists do. (They do this because they unerringly believe in the Primary Axiom, and assume that since the Primary Axiom is true that this data can be swept under the rug by nebulous processes such as punctuated equilibrium, Muller's ratchet, and others (which he explains if you don't know what they are). the problem with this is the genetic data supports none of these processes, and Sanford attacks that in this writing.)
I would not classify this book as an Intelligent Design book, as he does not focus the majority of text on Intelligent Design. This book is a critique of evolution through genetics. If you want to read about ID, Sanford does allude to a designer at times, and invites people to Christ in his final 2-page chapter stating his beliefs in Jesus as Lord and Savior.
If you are looking for a book on genetic problems behind evolution, and would like to have resources in the book to explain terms and processes (in the glossary and appendices), then this is the book.
Top reviews from other countries
Dan MercerReviewed in Australia on December 24, 20245.0 out of 5 stars Fascinating read. Well worth while
Well written and not too technical for one not having experience in the industry. Thoroughly enjoyed reading it. I gained some good knowledge.
Gail PotgieterReviewed in the United Kingdom on May 1, 20225.0 out of 5 stars Thorough examination of the basic premise of evolution
I thoroughly enjoyed reading this book. I have a M.Sc. in a biological field, but am also a Christian. While at university learning about genetics and evolutionary biology, I always thought that the arguments for evolution were not particularly strong. It is difficult to put your finger on exactly what the problem is, however, when you are still learning a great deal of new information and your teachers are all 100% convinced about evolution. This book helps clarify what one of those key issues are - that information contained in the genome of any living thing cannot be improved through a process of random errors followed by blind selection against the worst of these errors. The author of this book points out that the problem isn't that we need more time to make the process work, but that time itself is against the process. Further, none of the natural processes we know are capable of producing the kind of information found in the genome - the only things we have that even resemble this kind of information (albeit in a crude way) are computer microchips and software programmes, which were invented by intelligent people working from the products of other intelligent minds. To claim that the genome arose without any intelligent input is more far-fetched than to claim that the device you are using to read this message was created by accident.
ButtsReviewed in Canada on November 28, 20215.0 out of 5 stars good read
Easy enough to understand and referenced enough to be credible.
Jack DelmonteReviewed in Germany on December 31, 20205.0 out of 5 stars Physical laws make evolution impossible.
Great book. This book goes into detail and proves that evolution is a lie. It doesn’t surprise me that the laws of nature make evolution impossible.
Amazon KundeReviewed in Germany on January 4, 20215.0 out of 5 stars An eyeopener
Scientific and logical arguments that prove the weaknesses of the neo-Darwinian theory.









