- Paperback: 352 pages
- Publisher: Harper Perennial; 1 edition (October 3, 2000)
- Language: English
- ISBN-10: 0060932902
- ISBN-13: 978-0060932909
- Product Dimensions: 5.3 x 0.8 x 8 inches
- Shipping Weight: 8.8 ounces (View shipping rates and policies)
- Average Customer Review: 4.4 out of 5 stars See all reviews (350 customer reviews)
- Amazon Best Sellers Rank: #839,369 in Books (See Top 100 in Books)
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Genome: The Autobiography of a Species in 23 Chapters 1st Edition
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Science writer Matt Ridley has found a way to tell someone else's story without being accused of plagiarism. Genome: The Autobiography of a Species in 23 Chapters delves deep within your body (and, to be fair, Ridley's too) looking for dirt dug up by the Human Genome Project. Each chapter pries one gene out of its chromosome and focuses on its role in our development and adult life, but also goes further, exploring the implications of genetic research and our quickly changing social attitudes toward this information. Genome shies away from the "tedious biochemical middle managers" that only a nerd could love and instead goes for the A-material: genes associated with cancer, intelligence, sex (of course), and more.
Readers unfamiliar with the jargon of genetic research needn't fear; Ridley provides a quick, clear guide to the few words and concepts he must use to translate hard science into English. His writing is informal, relaxed, and playful, guiding the reader so effortlessly through our 23 chromosomes that by the end we wish we had more. He believes that the Human Genome Project will be as world-changing as the splitting of the atom; if so, he is helping us prepare for exciting times--the hope of a cure for cancer contrasts starkly with the horrors of newly empowered eugenicists. Anyone interested in the future of the body should get a head start with the clever, engrossing Genome. --Rob Lightner --This text refers to an alternate Paperback edition.
From Publishers Weekly
HSoon we'll know what's in our genes: next year, the Human Genome Project will have its first-draft map of our 23 chromosomes. Ridley (The Red Queen; The Origins of Virtue) anticipates the genomic news with an inventively constructed, riveting exposition of what we already know about the links between DNA and human life. His inviting prose proposes "to tell the story of the human genome... chromosome by chromosome, by picking a gene from each." That story begins with the basis of life on earth, the DNA-to-RNA-to-protein process (chapter one, "Life," and also chromosome one); the evolution of Homo sapiens (chromosome two, which emerged in early hominids when two ape chromosomes fused); and the discovery of genetic inheritance (which came about in part thanks to the odd ailment called alkaptonuria, carried on chromosome three). Some facts about your life depend entirely on a single gene--for example, whether you'll get the dreadful degenerative disease Huntington's chorea, and if so, at what age (chromosome four, hence chapter four: "Fate"). But most facts about you are products of pleiotropy, "multiple effects of multiple genes," plus the harder-to-study influences of culture and environment. (One asthma-related gene--but only one--hangs out on chromosome five.) The brilliant "whistle-stop tour of some... sites in the genome" passes through "Intelligence," language acquisition, embryology, aging, sex and memory before arriving at two among many bugbears surrounding human genetic mapping: the uses and abuses of genetic screening, and the ongoing debate on "genetic determinism" and free will. Ridley can explain with equal verve difficult moral issues, philosophical quandaries and technical biochemistry; he distinguishes facts from opinions well, and he's not shy about offering either. Among many recent books on genes, behavior and evolution, Ridley's is one of the most informative. It's also the most fun to read. Agent, Felicity Bryan.
Copyright 2000 Reed Business Information, Inc. --This text refers to an alternate Paperback edition.
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Top Customer Reviews
Some of the common errors:
-"The" replaced with "die,"
-"1" replaced with "i" (think "the years i957-i960")
-"tl" regularly replaced with "d" (think "Aristode" and "litde")
-Headings appear randomly in the text ("GENOME 157" in the middle of a sentence)
If you don't mind sentences like "Aristode discovered die GENOME 157 idea," (not an actual quote, but a representation of the regular errors) go for it. In science, however, names really matter. These types of errors render the entire text unreliable. Ever want to quote that interesting thing you learned? Well don't, because the book might have gotten the name wrong through a typo and you'll look like an idiot rather than a smarty-pants who reads scholarly books on the weekend.
I think there are enough reviews of the text itself to give a potential buyer a good idea of what they can expect, so I won't go into much other than the fact that I read these types of books regularly, and while I would definitely read it again (interesting ideas), I felt like I was trudging through the text. The author is particularly fond of letting you know he just lied to you or made something up, sometimes to demonstrate his points. Just like every gene should not be expressed, every idea that enters an author's mind shouldn't make it to the final print. So there you have it, an interesting but flawed production that could use some encouragement from natural selection.
A little more background into the process of extracting and identifying DNA would have been appreciated. Although this information may have not been complete at the time of the original publishing, in 2013 DNA was commonly used in criminal and civil courts, as well as some daytime talk shows.
Secondly, while I can appreciate the author's interjection of humor to lighten some of the heavier passages, it seems to happen too frequently and ends up detracting. In particular, a few analogies seem to be taken a bit too far after the point has been clearly made.
Lastly, the subject of Gene therapy (treatments) could use a better explanation of how the mechanism works to get the altered genes into the code of the patient.
Otherwise, it is an enjoyable read and an good introduction to the subject matter.
I have two issues with this recently published book. The first is that the material seems to be dated to about 2000 or so as indicated by several references made in the body of the text. A quick perusal of the bibliography shows references as late as 1998. So I am assuming this 2000 vintage book has just been digitized for consumption on ereaders which, if so, should have been flagged for the consumer. This leads me to my second issue which is that the digitization of this book has numerous errors which does not make it unreadable but is distracting to say the least.
All that being said, I found the book to be captivating and wish Ridley would provide an updated version to reflect the tremendous progress that has occurred in the field of genetics over the past 13 years.
Most Recent Customer Reviews
Info on why we have 23 chromosomes and our primate cousins have 24 is very...Read more