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Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers Hardcover – September 17, 2013
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In Grain Brain, renowned neurologist David Perlmutter, MD, exposes a finding that's been buried in the medical literature for far too long: carbs are destroying your brain. Even so-called healthy carbs like whole grains can cause dementia, ADHD, epilepsy, anxiety, chronic headaches, depression, decreased libido, and much more.
Groundbreaking and timely, Grain Brain shows that the fate of your brain is not in your genes. It's in the food you eat. The cornerstone of all degenerative conditions, including brain disorders, is inflammation, which can be triggered by carbs, especially containing gluten or high in sugar. Dr. Perlmutter explains what happens when the brain encounters common ingredients in your daily bread and fruit bowls, how statin drugs may be erasing your memory, why a diet high in "good fats" is ideal, and how to spur the growth of new brain cells at any age.
Dr. Perlmutter's revolutionary 4-week plan shows you how to keep your brain healthy, vibrant, and sharp while dramatically reducing your risk for debilitating neurological diseases as well as relieving more common, everyday conditions -- without drugs. Easy-to-follow strategies, delicious recipes, and weekly goals help you to put the plan into action. With a blend of anecdotes, cutting-edge research, and accessible, practical advice, Grain Brain teaches you how to take control of your "smart genes," regain wellness, and enjoy lifelong health and vitality.
- Print length336 pages
- LanguageEnglish
- PublisherLittle, Brown Spark
- Publication dateSeptember 17, 2013
- Dimensions6.5 x 1.25 x 9.75 inches
- ISBN-109780316234801
- ISBN-13978-0316234801
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Editorial Reviews
From Publishers Weekly
Review
"Dr. Perlmutter takes us on a detailed tour of the destructive effects that 'healthy whole grains' have on our brains. Modern wheat, in particular, is responsible for destroying more brains in this country than all the strokes, car accidents, and head trauma combined. Dr. Perlmutter makes a persuasive case for this wheat-free approach to preserve brain health and functioning, or to begin the process of reversal." --William Davis, MD, author of Wheat Belly
"If you want to boost your brain power, keep your memory, and lift your mood and energy, as well as heal from a host of other common complaints, Dr. Perlmutter is your guide. This is the definitive instruction book for the care and feeding of your brain!" --Mark Hyman, MD, author of The Blood Sugar Solution
"Dementia and many other brain diseases are not inevitable, nor are they genetic. They are directly and powerfully linked to a diet high in sugar and grains. Grain Brain not only proves this, it also gives you everything you need to know to protect your brain--or a loved one's--now."--Christiane Northrup, MD, author of Women's Bodies, Women's Wisdom
"This book is a treasure. It is filled with self-empowering wisdom and easily understood leading-edge science. It can help you to avoid the devastating effects of an unhealthy diet and the dietary factors which are involved. By learning from the information presented in Dr. Perlmutter's book, you can avoid multiple health and neurological problems."--Bernie Siegel, MD, author of Faith, Hope, and Healing and The Art of Healing
"A provocative, eye-opening scientific account of how diet profoundly influences nerve health and brain function. Grain Brain explains how the American diet rich in gluten and inflammatory foods is linked to neurological conditions. Dr. Perlmutter outlines a blueprint for optimal health and a more resilient brain through proper nutrition and lifestyle. Grain Brain is a must-read!"--Gerard E. Mullin, MD, Associate Professor of Medicine, The Johns Hopkins School of Medicine, and author of The Inside Tract: Your Good Gut Guide to Great Digestive Health
"Dr. Perlmutter is the leading integrative medicine neurologist in North America today. His ability to fully integrate conventional medicine diagnosis and treatment with the latest innovations in nutritional and environmental medicine is phenomenal. As a teacher and clinician, he has fundamentally changed how physicians and patients think about neurological degeneration and, happily, regeneration." --Joseph Pizzorno, MD, coauthor of Encyclopedia of Natural Medicine
"Dr. Perlmutter provides sound advice, supported by the latest and most well respected medical research." --Russell. B. Roth, MD, Past President, American Medical Association
"A galvanizing call to arms against a gluten-heavy diet....Perlmutter's credentials as a board-certified neurologist and American College of Nutrition Fellow make him a uniquely qualified voice in the debate about which foods are best for the brain and body." --Kirkus Reviews
"Mind-blowing and disruptive to some long-standing beliefs about what our bodies require for optimal health...GRAIN BRAIN lays out an easy-to-understand roadmap packed with the latest science." --Max Lugavere, Psychology Today
"A tour de force that is destined to save many lives. As I read this important and well-written book I found myself nodding my head vigorously in agreement at practically every page. [Grain Brain] gives us what we need to know to be well again. Please read it." --Health Central
About the Author
He is the author of the New York Times bestsellers Grain Brain, The Grain Brain Cookbook, and Brain Maker, as well as The Better Brain Book and Raise a Smarter Child by Kindergarten. He lives in Naples, Florida.
Product details
- ASIN : 031623480X
- Publisher : Little, Brown Spark; 1st edition (September 17, 2013)
- Language : English
- Hardcover : 336 pages
- ISBN-10 : 9780316234801
- ISBN-13 : 978-0316234801
- Item Weight : 1.25 pounds
- Dimensions : 6.5 x 1.25 x 9.75 inches
- Best Sellers Rank: #519,688 in Books (See Top 100 in Books)
- #424 in Alzheimer's
- #460 in Nervous System Diseases (Books)
- #2,779 in Other Diet Books
- Customer Reviews:
About the author

David Perlmutter, MD, FACN, ABIHM is a Board-Certified Neurologist, Fellow of the American College of Nutrition and six time New York Times bestselling author. He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. Dr. Perlmutter is a frequent lecturer at symposia sponsored by such medical institutions as Columbia University, the University of Arizona, Scripps Institute, and Harvard University. He has contributed extensively to the world medical literature with publications appearing in The Journal of Neurosurgery, The Southern Medical Journal, Journal of Applied Nutrition, and Archives of Neurology. He is the author of the #1 New York Times Bestseller, Grain Brain. Other New York Times bestsellers include Brain Maker, The Grain Brain Cookbook, The Grain Brain Whole Life Plan and New York Times bestseller, Brain Wash (January, 2020) co-written with his son, Austin Perlmutter, MD. He is recognized internationally as a leader in the field of nutritional influences in neurological disorders. Dr. Perlmutter has been interviewed on many nationally syndicated radio and television programs including 20/20, Larry King Live, CNN, Fox News, Fox and Friends, The Today Show, Oprah, Dr. Oz, and The CBS Early Show. In 2002 Dr. Perlmutter was the recipient of the Linus Pauling Award for his innovative approaches to neurological disorders and in addition was awarded the Denham Harmon Award for his pioneering work in the application of free radical science to clinical medicine. He is the recipient of the 2006 National Nutritional Foods Association Clinician of the Year Award. Most recently, Dr. Perlmutter was awarded the 2019 Global Leadership Award form the Integrative Healthcare Symposium. In December of 2017, Dr. Perlmutter lectured at the World Bank with his presentation broadcasted to 150 sites around the world. His books are now published in 36 languages. His latest work, New York Times bestseller, Drop Acid (February 15, 2022), explores how elevated uric acid powerfully threatens metabolic health, and how it can be brought under control.
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Learn more how customers reviews work on AmazonCustomers say
Customers find the information in the book very informative and compelling. They also say it's well-written, a good read, and important for everyone to read. Readers mention they have lost weight and less body aches than ever before. They enjoy the recipes and say they are delicious. Additionally, customers mention they have more energy and a clear mental state.
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Customers find the book very informative and a great resource for information on brain health and inflammation. They appreciate the compelling basic science and copious studies to back up his claims. Readers also say it provides information on how to avoid certain illnesses. Additionally, they mention it offers plenty of sound advice backed by sound science. Overall, they say the book contains all the information they need to know when eating something.
"...This book contains all the information that we have to know whenever we eat something...." Read more
"...My energy level is consistent all day. My hunger level has dramatically reduced and productivity has increased because I'm not getting up for snacks..." Read more
"...He provides a fairly good scientific analysis of the issue with some clinical and research references, although I wish he had been more thorough in..." Read more
"...You will have it figured out. No more secrets and you will see how the pharmaceutical industry and the food industry will lose vast amounts of money..." Read more
Customers find the book well-written, easy to read, and interesting. They say it's important for everyone to read and one of their favorite health books.
"...The headings were appropriately positioned and fully caught the attention of readers...." Read more
"...He provides some practical steps we can all take to improve our health and reduce our chances for a variety of conditions...." Read more
"...This lends great weight to his ideas, although his three decades of clinical and research-based experience lend even more...." Read more
"This is one of the most important book I have ever read on nutrition...." Read more
Customers find the book easy to follow and say it's a great way to lose weight. They mention it's no longer bloated, significantly lowers their intraday glucose levels, and stops all celiac lower GI issues.
"...I am sleeping better. I no longer feel bloated. My energy level is consistent all day...." Read more
"...My net weight is dropping! For one month I am trying to keep total carbs from all sources below 40 a day, as per Dr. Perlmutter's recommendations...." Read more
"...As for me--I lost weight easily, without trying. Nice side effect of just trying to do something for my kids...." Read more
"...I lost 10 pounds, feel amazing and am looking forward to living a vibrant rest of my life." Read more
Customers say the book has helped them feel better. They mention they have more energy, less body aches, and osteoarthritis symptoms have been dramatically reduced. They also mention that sugar levels are down, headaches are less frequent, and stomach troubles are non-existent.
"...blow away the anxiety and problems with concentration, reduce the headaches, rev up my energy levels and increase my levels of alertness are..." Read more
"...I'm still wheat free after 8 months and have felt great. Less knee pain, my arthritic hands are so much better and best of all my gut has stopped..." Read more
"...less headaches – a LOT less, tummy troubles are now non-existent, and before, I was always gaseous or had diarrhea, or..." Read more
"...I feel so much better. I shared this book and what I've learned with others and for many the results have been huge. Physically and mentally...." Read more
Customers find the recipes in the book delicious, healthy, and filling. They appreciate that the author doesn't stop at food advice. Readers also mention that the eating plan is simple and delicious.
"...Finally, I appreciated the fact that the author did not stop at food advice...." Read more
"...The meal is delicious, healthy and filling...." Read more
"...There are also a few easy recipes in the back of the book mostly geared towards individuals who have never eaten gluten free before...." Read more
"...I purchased his matching cookbook; it makes cooking so easy. My husband loves the new lifestyle...I have lost almost 50 lbs...." Read more
Customers find the book has a positive effect on their energy levels. They mention it has a clear mental state and a definite improvement in thinking capacity. Readers also say it dials back compulsive or impulsive behaviors.
"...6 days a week for 30-45 minutes at a time and I have plenty of energy throughout the day...." Read more
"...your food cravings, increases your energy levels, and dials back your compulsive or impulsive behaviors, some variant of this regimen may be for you...." Read more
"...His energy levels went through the roof?..." Read more
"...What I’ve gained are increased energy, lots less brain fog, joints moving better (do not hurt all the time), less headaches – a LOT less, tummy..." Read more
Customers find the book compelling, shocking, and provoking. They say it's convincing, intriguing, and believable. Readers also mention the book is disturbing and challenging.
"...What you learn in this book is eye-opening, frightening and also life changing...." Read more
"...Overall though, the book is convincing, compelling, and I think will prove to be important and right in most all respects...." Read more
"...The evidence is damning, unbelievably abundant and shocking...." Read more
"...What was also interesting was that my state of mind was very volatile during this period of weight loss...." Read more
Customers have mixed opinions about the gluten content of the book. Some mention it's a great review of the effects of gluten on the brain and joints. They also say it explains very clearly how consumption of gluten, grains, and even other carbohydrates can be harmful. However, others say the diet is impossible and the most difficult dietary program they have attempted.
"...Physically and mentally. Huge improvements in allergies and certain medical conditions. Not needing certain medications any more......" Read more
"...Then in the last 10% he adds a pretty lamb and skimpy diet outline and points you to his website to buy supplements and tests...." Read more
"...It explains very clearly how consumption of gluten, grains and even other carbohydrates (both simple and complex) affect metabolism, create allergies..." Read more
"...Here's the tldr; version: Gluten is bad. Carbs are bad. Include B vitamins in your regimen...." Read more
Reviews with images
Excellently written & plenty of references!
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In the introduction of this book, Dr. Perlmutter includes self-assessment page where the readers can define what are their risk factors for getting brain disorders. He also explains that he would provide information useful for the following brain illness: ADHD, anxiety, depression, diabetes, epilepsy, dementia, etc. He states that he would prove to the readers about how daily habit affects the function and long-term health of brain.
Part 1, "The Whole Grain Truth", discusses about the common ingredients such as wheat and fats that are both friends and enemies of the brain. It is divided into six chapters, the first three chapters discusses about the inflammation process, the role of gluten, carbohydrates and fats in inflammation, and the inflammation as the heart of brain disease. He also covers psychological and behavioral disorders that food choices can change an individual genetic characteristic and eventually leads to the brain illness. In the last chapter of part 1, the author focuses on how the gluten can impinge the long-term health and functions of the brain; people should keep breads away from them.
Part 2, "The Grain Brain Rehab", mainly discusses about the science beyond the habits that support a healthy brain. Divided into three chapters, he explores the relationship of nutrition and supplements, exercise, and sleep to brain disorders individually. He recommends the dietary habits that people should follow for healthy brain: the daily exercise routine to have better genes in the brain: the sleep routine to maintain stable hormone levels.
In the part 3, "Say Good-Bye to Grain Brain", the author actually recommends a month-long program with the meal plan, recipes, and weekly goal. He, in details, provides what should be taken everyday, and what must be forbidden for intake during lifetime. This recipe and diet plan would lead people to change their diet habits and help keep healthy brain consistently.
In this book, the style and structure is simple and easy to follow. First, Dr. Perlmutter follows the structure of having a proposal, evidences and recommendations. He first proposes how each nutrient and daily habits can affect the health of brain. Then, he provides evidence to support his thesis by explaining the chemical and biological mechanism of each food intake and the effect of sleep and exercise. Finally, he gives a recommendation on how to avoid brain illness in the future with his own version of meal plan, recipe, and weekly goals. Therefore, people with no scientific background can all understand what the author is trying to explain. Also, whenever he introduces new biochemical concepts, he explains in-depth so that readers will not get lost. In the beginning of each chapter, he gives an overview of what will be in there. For example, in chapter 6, he gives all the list of changes that sugars can trigger in the short-term basis: behavior, seize control of focus and concentration, tic disorders and mood conditions such as depression. In terms of the style, I was able to observe the author's effort of trying to make a connection with the readers by questioning and stating his past daily habits. The readers would fully respond only if they have the same experience as the discussion topic of the author. However, there were not enough pictures or graphs that could assist the readers to understand the context. The font size and spacing was viewable. The headings were appropriately positioned and fully caught the attention of readers.
I read this book to find out the relationship between diet and Alzheimer's disease. The book covered this topic with appropriate volume but the book itself actually gave full information about the effect of each nutrient and supplements on the health of brain. First, he proved that the inflammation would lead to the cause of Alzheimer's disease because of "toxic sugar inflicts"(pg. 29). The insulin resistance from sugar, "sparks the formation of those infamous plaques that are present in diseased brains", especially in Alzheimer's disease (pg. 30). Because these plaques would buildup and take place of normal brain cells, the diabetes patient will have higher chance of getting Alzheimer's disease. It was interesting to see how diabetes and Alzheimer's disease was related together. I have read several research articles about their relationship but it was interesting to find out how food intake can be a key connector between these two diseases. In the later chapter, he also discusses about the increased risk of Alzheimer's disease due to diabetes. Since diabetes are also caused by high intake of carbs and sugars, it will definitely increase the risk of Alzheimer by increasing the inflammation and triggering the formation of insoluble protein plaques.
He also included a report, published in 2005, to indicate the relationship between the cholesterol level and cognitive ability. As Alzheimer's diseased patients have very low cognitive ability, I believed that high cholesterol level would actually decrease the cognition. However, he stated "people who had the highest cholesterol levels scored higher on cognitive tests than those with lower levels"(pg. 34). It was interesting to find out that there has to be a "protective factor" from cholesterol that can maintain the cognitive skills.
He then defines the elevations of cytokine as the hallmarks of the Alzheimer's disease. Gluten "increases the production of inflammatory cytokines" and such inflammation can actually prevent the production of soluble proteins and deposition of unnecessary cells in the brain, increasing the formation of insoluble plaques.
This book is definitely giving an advice to lose wheat and maintain low sugar level in our body. The intake of grain is actually increasing the risk of many brain disorders including ADHD, severe depression, dementia, Alzheimer's disease, etc. I would recommend this book even to the patient so that they do not have to solely depend on the medication, rather they should try a new lifestyle as Dr. Perlmutter recommends in the last chapter. This book is also recommended for young generation who has enough time to prevent the brain illness by reading this book and altering their diet plan. For potential readers, I would recommend to write current daily food intake before reading this book. By analyzing what you have eaten everyday based on this book, you would be able to find out your own risk factors to brain disorders. Also, try to read this book with whole family. Your daily food intake highly depends on family members, thus to get altered in a short term you must change your family's lifestyle.
I get the sense from his writing that Dr. Perlmutter is genuinely passionate about our health and really wants to turn around the disturbing rise in obesity, diabetes, and dementia in this country. He provides some practical steps we can all take to improve our health and reduce our chances for a variety of conditions. He and his wife even assembled a variety of easy and delicious recipes to help with the transition. There are a lot of supplements to take, however, which can get expensive. The way I see it, it's got to be cheaper than treating diabetes.
So my wife and I immediately started incorporating many of the changes to our lifestyle that he recommends, and we have never felt better. I have already lost 5 pounds in the three weeks since we started. I am sleeping better. I no longer feel bloated. My energy level is consistent all day. My hunger level has dramatically reduced and productivity has increased because I'm not getting up for snacks all the time. I no longer feel the need to nap during the afternoon. I have also noticed my focus has improved somewhat, I am definitely getting more done. The occasional numbness and tingling in my hands and feet is gone, along with the inflammation that was causing it.
We did not go cold turkey on the gluten free right away, it has been a gradual process and we keep finding foods in our pantry that we overlooked. So far the gluten free substitutes we have found for our favorite products have been pretty good. The transition to gluten free / low carb is definitely a huge shift in our lifestyle and more challenging than I expected. But the potential payoff is huge, and we can already feel the benefits starting to kick in.
I have to thank Dr. Perlmutter and his team for putting this out there. It is a bold move with so much of our economy dependent upon cheap processed grain products and sugary snacks/drinks. Critics, powerful agencies/organizations, and "flat-earther nutritionists" whose livelihoods depend on the products and old long-held beliefs will no doubt try to discredit the science behind this book and attack Dr. Perlmutter himself. It will be fascinating to see how this plays out.
-- Update 3/6/14 --
It has been about five months now since I started this, and so I thought I would post a quick update. My wife and I have stayed on the program pretty consistently but we do indulge in carbs and wheat products every couple of weeks or so for birthdays and other special occasions. We both feel great and I have lost 33 pounds so far. I am now able to work out 6 days a week for 30-45 minutes at a time and I have plenty of energy throughout the day. I have added weight training to my routine and I am now lifting more than when I was in my twenties. In fact, I had to upgrade my Bowflex with an additional 100lbs because I have outgrown the factory set of resistance rods.
We continue to enjoy the benefits I outlined in my original review, but there are a few new and unexpected effects that I have observed. First, my sleep feels very deep and when I wake up I feel much more rested and refreshed that before. Another surprise for me was a tingly toe that I've had for years now feels normal again. I think it may have been a pinched nerve somewhere caused by my excess weight or perhaps inflammation. I was convinced that was going to be with me for life, but it's completely gone now.
Perhaps the most surprising thing is, at least for me, is that people are telling me how awesome my skin looks. I've noticed it too, my skin actually looks and feels younger and healthier. My wife too, she's absolutely thrilled about this unexpected benefit. I'm not sure if it's the supplements, the diet, or the exercise, but wow what a difference this had made in our overall quality of life. I highly recommend this book, it's truly a game-changer.
Top reviews from other countries
the book "wheat belly" by william davis is also a must read for anyone who wants to enjoy good health, mentally physically and emotionally. a great book on this important subject.
diseases are often not at all what they seem. Ill health is often triggered by one of two foods that are in everything we eat. Understanding the impact of this, and exactly how the body actually works, is key to curing health issues.
these books are easy to read primers for understanding the complex matters of human health, physical and emotional. The more you learn about the body, the more you understand that brain and emotional or behavioural issues often have physical (food related ) causes. Also our sleep habits, which trigger our eating habits/cravings for these same foods that are so destructive. "lights out"- Sleep, sugar and survival, a book by TS Wiley and Bent Formby is excellent as well, on the subject of sleep dysfunction tr carbohydrate cravings, weight gain and disease.
Vale cada minuto de aprendizado! A linguagem é clara e fácil de entender! Super Recomendo!
Según lo presenta el autor, SI es EVITABLE el deterioro de nuestro cerebro, incluso, con la adecuada alimentación y otras medidas como el ejercicio constante y regular, no solo evitable, sino hasta lo podemos mantener y mejorar.





