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Dennis Kasper, MD is Professor of Medicine at Harvard and a leading researcher of the health and disease implications related to host-microbe interactions and the human microbiome. Anthony Fauci, MD is Director of the National Institutes for Allergy and Infectious Diseases, and recipient of the Lasker Prize for Medicine. He is a leading authority in HIV and AIDS, immunology, and management of Ebola Virus Disease. Dan Longo, MD is Deputy Editor, New England Journal of Medicine and Professor of Medicine, Brigham and Women's Hospital/Harvard Medical School. Dr. Longo is a highly regarded cancer specialist. Stephen Hauser MD is Robert A. Fishman Distinguished Professor and Chair, Department of Neurology, UCSF School of Medicine. He is a leading authority on multiple sclerosis. J. Larry Jameson, MD, PhD is Robert G. Dunlop Professor of Medicine, Dean, University of Pennsylvania School of Medicine, and Executive Vice President, University of Pennsylvania Health System. Joseph Loscalzo MD, PhD is Hersey Professor of the Theory and Practice of Medicine, Harvard Medicine School and a leading authority in many aspects of cardiovascular medicine.
I have been using HPIM as my reference book since the 15th edition. Overall it's a great book and they are getting better all the time by adding tables, charts and color that helps remembering stuff. However this new edition has some major drawbacks:
1. While it seems like a good idea to make a small problems-based volume and a larger diseases-based volume, this is just not practical. Not only the larger volume is heavy and difficult to move around the desk, it is also difficult to read since pages curve very deep into binding due to the volume size.
2. I am not sure how authors decided which chapters will be available only on the disk. For example, one of my favorite chapters about transfusion therapy has disappeared from the book and exists only on the disk. I find this ridiculous - every hospital-based physician deals with transfusions all the time. It is much more important for vast majority of internists to know how to manage transfusions and their complications than to be experts in Tularemia, Relapsing Polychondritis or MEN - and these chapters made it to the paper! Other examples of important chapters that can be found only on the disk are Bone Cancer, Antiviral therapy, Poisoning and drug overdose etc. etc. etc.
As an experienced clinician, I find Harrison's to remain the definitive source for medical knowledge. The electronic version makes access to this knowledge fast and easily carried on ipad or similar devices.
The last edition I bought was the 16th back in medical school. This continues to be the bible of medicine & a must for every clinicians who seeks a thorough understanding of disease and medical practice.