Enter your mobile number below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required.
Getting the download link through email is temporarily not available. Please check back later.

  • Apple
  • Android
  • Windows Phone
  • Android

To get the free app, enter your mobile phone number.

Buy Used
$29.99
Condition: Used: Like New
Comment: Ex-Library Book - will contain Library Markings. Book is in great condition!
Have one to sell? Sell on Amazon
Flip to back Flip to front
Listen Playing... Paused   You're listening to a sample of the Audible audio edition.
Learn more
See this image

How the Cows Turned Mad Hardcover – March 15, 2003

4.3 out of 5 stars 8 customer reviews

See all 2 formats and editions Hide other formats and editions
Price
New from Used from
Hardcover
"Please retry"
$3.50 $0.01
click to open popover

Editorial Reviews

From The New England Journal of Medicine

In How the Cows Turned Mad, Maxime Schwartz recounts the history of the prion diseases, or subacute spongiform encephalopathies, as if writing a mystery. Schwartz refers to all the prion diseases under one rubric, "The Disease," as if a single criminal with many disguises were active. This story has truly been an exceptional one, with events that have dramatically and unexpectedly affected the economy, public health, and the political scene. We now know that there are a number of subacute spongiform encephalopathies of animals (e.g., scrapie and "mad cow disease," or bovine spongiform encephalopathy) and of humans (e.g., kuru and Creutzfeldt-Jakob disease) that are transmissible and that have similar pathologic features. The transmissible agent, a prion, is a misfolded protein (called PrP(sup Sc)) that has assumed a conformation different from that of the normal cellular form of the protein (called PrP(sup C)). In the presence of PrP(sup Sc), PrP(sup C) is converted into additional molecules of PrP(sup Sc), which then accumulates, resulting in the induction of disease. The prion is remarkable because it apparently contains no nucleic acid, triggers no immune response, causes a disease with an extraordinarily long incubation period, and is highly resistant to inactivation by physical and chemical agents (such as heat and formalin) that normally are expected to inactivate a pathogen. One of the attractive features of this book is its historical perspective, beginning with coverage of early records related to scrapie in 17th-century England and ending with a discussion of recent concerns in France about the spread of bovine spongiform encephalopathy and a new variant of Creutzfeldt-Jakob disease that has been strongly linked to bovine spongiform encephalopathy. The work of Pasteur is highlighted, presumably in part because Schwartz previously served as head of the Pasteur Institute. Schwartz reviews the many ways in which the prion diseases have surprised us and also covers recurrent themes that have frequently been overlooked. For example, in the 1930s scrapie was transmitted to sheep by means of inoculation with a formalin-treated vaccine against the virus that causes louping ill. The vaccine transmitted scrapie because it had been prepared from sheep that were presumed to have unrecognized scrapie and because scrapie resists formalin inactivation. This event presaged instances of iatrogenic spread of the subacute spongiform encephalopathies, such as one in which Creutzfeldt-Jakob disease was transmitted by the implantation of electrodes that had previously been used in an affected person and on which prions had been incompletely inactivated by formaldehyde vapor. The transmission of kuru after ritual cannibalistic ingestion of the tissues of relatives who had died of kuru reminds one of how bovine spongiform encephalopathy became endemic in cattle as a result of the ingestion of feed that contained contaminated cattle carcasses. Schwartz informs us that these events are reminiscent of a still earlier event recognized by Nocard, a student of Pasteur, in which anthrax was spread from fertilizer that had been prepared from carcasses of anthrax-infected animals. The subacute spongiform encephalopathies still have much to teach us, both about their pathogenesis as well as about the role of misfolded proteins in other neurodegenerative diseases. We will need to attend to the history of these diseases carefully and also be guided by current data in order to ensure that we respond appropriately in the future to the surprises of these diseases. How the Cows Turned Mad should be understandable to readers with a relatively limited scientific background; however, it would have been helpful for Schwartz to have provided some figures to show, for example, the conversion of PrP(sup C) into PrP(sup Sc). The information about these diseases is reasonably current, with only rare errors. In the interest of space, Schwartz unfortunately was selective in his discussions of prion disease and in listing references and crediting scientists who contributed to knowledge in this field. Pasteur wrote, as cited by Schwartz, "Might it not be permitted to believe . . . that the day will come when easily utilized preventive measures will end these scourges which abruptly afflict and terrify people . . . ?" In these times of outbreaks of West Nile virus infection and the severe acute respiratory syndrome, one cannot help but think of the more cautious and somber comment of Claudius in Shakespeare's Hamlet: "Diseases desperate grown / By desperate appliance are relieved, / Or not at all." Some stories that involve intrigue and human tragedy, such as Hamlet, will always challenge us and leave unanswered questions. Raymond P. Roos, M.D.
Copyright © 2003 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

From Booklist

*Starred Review* Two and a half centuries ago, sheep in England started trying to scrape their wool off; in France, to shake uncontrollably. The Brits dubbed their phenomenon scrapie; the French called theirs tremblant. Between then and now, similar conditions in cows and humans were discovered and assigned the group name transmissible spongiform encephalopathies (TSEs): diseases that fill the brain with holes as in a sponge and spread from one organism to another. Their cause eluded researchers until quite recently. SOP since Pasteur sought an invasive bacterium or virus with increasingly powerful tools, which TSE agents eluded. Eventually, evidence pointed to a genetic cause involving transformation of a normal into a deviant gene by another deviant gene introduced orally into the affected organism. You had to eat something from a sick organism to become sick, and once that became popular knowledge after the concurrence of human and bovine TSE cases in England in the 1990s, there was a panic. That reaction seems unjustified; according to Schwartz, TSEs will continue to be a very minor cause of human death. Meanwhile, there may be much to learn from TSE research about such symptomatically similar illnesses as Alzheimer's disease. Writing with immense concentration and clarity, French molecular biologist Schwartz makes the long hunt for the unexpected culprit gene utterly engrossing. Ray Olson
Copyright © American Library Association. All rights reserved
NO_CONTENT_IN_FEATURE

New York Times best sellers
Browse the New York Times best sellers in popular categories like Fiction, Nonfiction, Picture Books and more. See more

Product Details

  • Hardcover: 238 pages
  • Publisher: University of California Press; 1 edition (March 15, 2003)
  • Language: English
  • ISBN-10: 0520235312
  • ISBN-13: 978-0520235311
  • Product Dimensions: 9.3 x 6.3 x 0.9 inches
  • Shipping Weight: 1.1 pounds
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (8 customer reviews)
  • Amazon Best Sellers Rank: #3,904,054 in Books (See Top 100 in Books)

Customer Reviews

Top Customer Reviews

By Rodger Shepherd on August 9, 2012
Format: Paperback
I refer the reader to the other reviews for a description of the content of the book. I simply want to align myself with those reviewers who were enthusiastic about this book. The story of the transmissable subacute spongioform encephalopies is very engagingly and authoritatively told by the author (who is a "he" - not a "she"). If you like the sort of stories that Berton Roueche wrote, then you will enjoy this book. Among other things, this book is a wonderful reminder that medicine is a constant "work in progress" and that seemingly esoteric research can suddenly become very relevant.

I would note that the book takes the story to 2003. Subsequent developments are easily tracked down with Google. I found current introductary articles on protein folding very helpful.
Comment 2 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Paperback
An amazing tour of the history of prion diseases. From start to finish, it's well written, beuatifully explained and frighrening. If this book hasn't scared you, read it again
Comment 3 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Paperback
Over the past sixty years bovine spongiform encephalopathy (BSE), or "mad cow disease", has become a popular neurological topic in society due to the increasing fear and anxiety concerning it's association with variant Creutzfeldt-Jakob disease (vCJD). How the Cows Turned Mad expands upon the history behind the discovery of the fatal brain infection in sheep and follows through to its subsequent appearance in both cows and humans. The book presents the histology and physiology of transmissible spongiform encephalopathy (TSE) by examining the diseases from multiple scientific standpoints. With a background in molecular biology of bacteria, the author of How the Cows Turned mad - Maxime Schwartz is a professor at the Institute Pasteur in Paris as well as the Director of Laboratories for the French Food Safety Agency. While working for the French Food Safety Agency Schwartz chaired a committee that advised the French government on the licensing of genetically modified organisms for general consumption. While some topics of the book may be frightening, the main concept is to provide information on BSE and other associated brain infections so that people can have a understanding of the diseases origins and transmission. The book presents the current information on BSE with the intent to educate the general public while also detailing the disease process and histology of the infections in a format that scientists in the neurological disease field could appreciate. There were many good sections of the book that I found highly enjoyable, with lots of interesting cases involving the diseases which were presented in a educational way that could be easily understood.Read more ›
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Paperback
Schwartz does a good job with the history of scrapie, kuru, vCJD, etc. However, once we get to Prusiner and prion territory, while she does a good job of explaining his conclusions (along with those who generally agree), she doesn't fully look at the controversy over prions, or the controversy over whether or not Prusiner was making a "Nobel push."

This is a solid introduction, but read somebody like Richard Rhodes, "Deadly Feasts," for much more detail on the modern end. (Rhodes does a bit much ax-grinding on Prusinder, though.)
Comment One person found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse

Pages with Related Products. See and discover other items: diagnostic pathology