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Why Isn't My Brain Working?: A Revolutionary Understanding of Brain Decline and Effective Strategies to Recover Your Brain's Health Paperback – Illustrated, May 1, 2013
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Enhance your purchase
- Print length624 pages
- LanguageEnglish
- Publication dateMay 1, 2013
- Dimensions8.9 x 5.9 x 1.56 inches
- ISBN-109780985690434
- ISBN-13978-0985690434
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Editorial Reviews
About the Author
As a researcher, Dr. Kharrazian earned a PhD degree in Health Science with concentrations in immunology and toxicology and a Doctor of Health Science (DHSc) degree from the Department of Health Care Sciences at Nova Southeastern University. He completed his post-doctoral research training as a research fellow at Harvard Medical School and worked as a researcher at the Department of Neurology at Massachusetts General Hospital, where his research focus was in autoimmunity and neuroimmunology. Dr. Kharrazian also earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School. Dr. Kharrazian is an active member of the Harvard Medical Alumni Association and the American Association of Immunologists.
In 2010, Dr. Kharrazian's book, Why Do I Still Have Thyroid Symptoms When My Lab Tests are Normal? completely changed the paradigm of how thyroid disorders are managed.Dr. Kharrazian is the author of the best-selling book, Why Isn't My Brain Working?, a well-reviewed and an exhaustively referenced book that illustrates Dr. Kharrazian's model for supporting the brain.
Dr. Kharrazian has a private practice in San Diego, California. He consults with patients from all over the world who are seeking non-pharmaceutical applications. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches.
Product details
- ASIN : 0985690437
- Publisher : Elephant Press; Illustrated edition (May 1, 2013)
- Language : English
- Paperback : 624 pages
- ISBN-10 : 9780985690434
- ISBN-13 : 978-0985690434
- Item Weight : 1.99 pounds
- Dimensions : 8.9 x 5.9 x 1.56 inches
- Best Sellers Rank: #90,625 in Books (See Top 100 in Books)
- #90 in Nervous System Diseases (Books)
- #199 in Neurology (Books)
- #1,688 in Alternative Medicine (Books)
- Customer Reviews:
About the author

ABOUT THE AUTHOR
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN is a Harvard Medical School trained and award-winning clinical research scientist, academic professor, and world-renowned functional medicine health care provider. He develops evidence-based models to treat autoimmune, neurological, and unidentified chronic diseases with non-pharmaceutical applications. His clinical models of evidence-based medicine are used by several academic institutions and thousands of health care providers throughout the world. Dr. Kharrazian is an Associate Clinical Professor at Loma Linda University School of Medicine.
As a researcher, Dr. Kharrazian earned a PhD degree in Health Science with concentrations in immunology and toxicology and a Doctor of Health Science (DHSc) degree from the Department of Health Care Sciences at Nova Southeastern University. He completed his post-doctoral research training as a research fellow at Harvard Medical School and worked as a researcher at the Department of Neurology at Massachusetts General Hospital, where his research focus was in autoimmunity and neuroimmunology. Dr. Kharrazian also earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School. Dr. Kharrazian is an active member of the Harvard Medical Alumni Association and the American Association of Immunologists.
As a health care provider, Dr. Kharrazian earned a Master of Science degree in Human Nutrition from the University of Bridgeport and a Doctor of Chiropractic degree from Southern California University of Health Sciences. He has completed board certifications in nutrition and neurological rehabilitation. Dr. Kharrazian’s clinical expertise is in developing personalized lifestyle medicine approaches to autoimmunity and neurological disorders.
Dr. Kharrazian is a Fellow of the American College of Nutrition, a Diplomate of the Board of Nutrition Specialists, a member of the American Society for Nutrition, a member of the American Association of Immunologists, and a Fellow of the Royal Society of Medicine (United Kingdom).
He has published scientific papers in the fields of nutrition, neurology, autoimmunity, and toxicology. He is currently conducting research in autoimmune molecular mimicry and environmentally induced immune reactivity. He is on the scientific editorial board for the Journal of Functional Neurology, Rehabilitation and Ergonomics and Alternative Medicine Therapies in Health and Medicine.
Dr. Kharrazian has received many awards for his work as a researcher, clinician, and educator. The American College of Nutrition honored Dr. Kharrazian with the Alexander and Mildred Seelig Award, which recognizes highly esteemed scientists for their outstanding contributions to the scientific field of nutrition. He has been a two-time recipient of the Researcher of the Year award by the International Association of Functional Neurology for his breakthrough research on neurological autoimmunity. He received an Award of Recognition by the Institute for Clinical Ergonomics and Applied Neuroscience for his outstanding contributions as an educator in the field of neurological therapeutics. He was also the recipient of the Clinical Trailblazer Award by the International Association of Functional Neurology and Rehabilitation for his contributions in evolving clinical therapeutic strategies used to treat patients suffering from neurological diseases.
Dr. Kharrazian was an adjunct professor at Bastyr University, where he taught neuroscience and human brain dissection for several years. He also serves as an adjunct professor at National University of Health Sciences, where he has developed several post-graduate programs in neurological disease diagnosis and clinical management. He has developed a Neuroendocrine-Immune Series and a Mastering Brain Chemistry course that has been that has been approved for postgraduate education by the University of Bridgeport.
As a medical educator, Dr. Kharrazian has developed many post-graduate courses in blood chemistry analysis, hormone and endocrine management, complex immunology testing, gastrointestinal management, and various topics in functional medicine. Dr. Kharrazian has trained a team of educators to teach his clinical models in managing chronic disease throughout the United States. Dr. Kharrazian’s clinical approaches are taught at more than 200 locations annually.
Due to the growing demand from healthcare professionals to learn Dr. Kharrazian’s clinical models to manage chronic diseases directly from him, he developed the Kharrazian Institute. The courses at the Kharrazian Institute are attended by a worldwide audience of more than a thousand physicians and healthcare providers.
In 2010, Dr. Kharrazian’s book, "Why Do I Still Have Thyroid Symptoms When My Lab Tests are Normal?", completely changed the paradigm of how thyroid disorders are managed. He was the first author to describe how thyroid dysfunction treatment needs to emphasize an autoimmune approach. His book became an international bestseller and led to the development of the largest Facebook Hashimoto’s community (Hashimoto’s 411), which supports thyroid patients from around the world.
Dr. Kharrazian is the author of the best-selling book, "Why Isn’t My Brain Working?", a well-reviewed and an exhaustively referenced book that illustrates Dr. Kharrazian’s model for supporting the brain. Based on the inability to meet the overwhelming demands for patient appointment requests, Dr. Kharrazian also created an online course called, "Save Your Brain: The Six Week Brain Rescue Plan", to provide a resource for many patients that needed guidance in finding ways to support their brain.
He also created the online course "The 3D Immune Tolerance Program: Build a More Resilient, Less Reactive Immune System". This course was developed to help people suffering from multiple food sensitivities, chemical sensitivities, and autoimmunity.
Dr. Kharrazian has been a consultant to the nutrition industry and has formulated more than one-hundred products that are used by thousands of healthcare professionals. He also serves as a consultant to immunological laboratories, providing expert clinical opinions in the development of complex immunology profiles.
Dr. Kharrazian has a private practice in San Diego, California. He consults with patients from all over the world who are seeking non-pharmaceutical applications. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches. Most of Dr. Kharrazian’s patients are referrals from other health care providers who require his unique skills in dissecting the patient’s case and implementing personalized strategic approaches.
https://drknews.com
https://kharrazianinstitute.com
http://.thyroidbook.com
http://.brainhealthbook.com
TESTIMONIALS
"Dr. Datis Kharrazian is one of the most powerful clinicians of our time. From the lab to the clinic, he has studied, vetted, and applied his cutting edge science to heal patients all over the world. I consider him to be a foremost authority in a systems approach to recovery and wellness."
— Kelly Brogan, MD
Author of "A Mind of Your Own"
https://kellybroganmd.com
"Dr. Kharrazian is a brilliant pioneer in innovative treatments for thyroid, brain and autoimmune health. His work and his deep care and compassion for patients is truly a gift to us all, and has transformed and empowered countless lives — mine included. I am deeply grateful for his contributions and dedication to uncovering the root causes of disease and for sharing his findings so generously!"
— Izabella Wentz, Pharma
Author of "Hashimoto's Thyroiditis: Lifestyle Interventions for Finding the Root Cause."
https://thyroidpharmacist.com
"Datis Kharrazian is truly among the great medical geniuses of our time. His capacity to think outside the box and coherently connect a myriad of dots amidst all of the overwhelming cavalcade of conflicting and often confusing information is virtually second to none. He brings genuinely cutting edge and unique, transformative insights to the table that others have missed along the way and for this we should all be eternally grateful."
— Nora Gedgaudas, CNS, NTP, BCHN
Author of "Primal Body, Primal Mind: Beyond Paleo for Total Health and Longer Life”
https://www.primalbody-primalmind.com
“Dr. Kharrazian’s material is way beyond the stuff they teach in medical school.”
— Ron Manzanero, MD
Austin Integrative Medicine, Austin, TX
“I have attended all of Dr. Kharrazian’s seminars. His approach has caused me to rethink how I approach treatment. This is excellent material.”
— Robert Mathis, MD, ABHM, CNS, MCP
http://baselinehealth.net
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I read a review where the person did not like this book because it was full of information on supplements and disorganized. wow. All I can say is that this book is the best out of the three books I purchased on brain health. This book is written more like a owners manual. It does not read well if you are looking for a novel. Sometimes I have to go to the index and find the information I want, like I said, an owners manual. The author also has really done his research which I like. He backs up his statements with citations to studies vs. someone just telling me his or her opinion. I read about 1/3 - 1/2 of the book. There are just some aspects of information in the book that do not pertain to me or not interested in; however, it might pertain to someone else and what does pertain to me is priceless. If you want to keep your brain healthy I highly recommend this book.
Pros:
- Excellent useful information
- Backs up statements with studies
- Detailed foods/supplements information
- Explains why things happen
- Warns you about "false" symptoms while your brain heals <= very important
- It's the best $20 I've ever spent
Cons:
- This book does not read like a novel, so if you're looking for a book to curl up in front of a fireplace and read front to back, this might not be written to your liking. However, my suggestion would be to not read it like a novel and more like a self help book to zero in on what you need to know to keep your brain healthy.
- Maybe not perfectly organized, but that's like complaining about what color the ambulance is painted while having a heart attack
INFORMATION ABOUT BRAIN SUPPLEMENTS: 2018 update
Alpha GPC is a great mental booster, but it is expensive. Over 4 years of learning, trial and error, I want to pass on something that took me a long time to figure out - which is, how to get a longer lasting effect of Alpha GPC without breaking the bank. So, I am passing along that information as well as some knowledge of supplements that have helped me out. Your needs might be different than mine, so I am not recommending you use them. I am just providing information that you can use as a starting point for your own research and in combination with reading this book.
These are the two powerhouses I take to boost mental acuity on a more longer term basis. With this combination, I have less need to use Alpha GPC, which saves me a lot of money. You can add these to orange juice with little effect to taste. The best part is that I can afford to take them because they are provided in bulk powder. Together, they will allow your body to build the AcetylCholine neurotransmitter. Think of it like taking protein powder to build muscle. You will not find this combination of products suggested in any books (none that I have found). It is based on my own research and a lot of trial and error. It maximizes effect with minimal cost. I'm passing it along so you can benefit from my experiences.
Bulksupplements Choline L-Bitartrate Powder (250 grams) - I use this as more of a long term to build up Choline in the brain. This form is absorbed better than the "DL-Bitartrate" form. The "L" form is better than the "DL" form also because it does not cause any upsets in the GI tract (from personal experience).
BulkSupplements Pure Acetyl L-Carnitine (ALCAR) Powder (250 grams) - I use this to supplement the Acetyl group. The reason this is important is because it combines with the Choline to make the neurotransmitter AcetylCholine. When the Acetyl is separated, the L-Carnitine is left to be used as an Amino Acid, which is also beneficial to boost energy.
These are some good supplements that support brain health.
Now Foods Sunflower Lecithin Powder, 1 Pound - Lecithin makes up about 30% dry weight of the brain. I take it to supply this building block for the brain much the same way a body builder takes protein for the muscles.
NOW Alpha GPC 300 mg,60 Veg Capsules - I take this to quickly boost Choline. It is a form of Choline that can pass through the blood-brain barrier. For example, a student can take it before taking an exam, or one can take it if they have brain fog.
BulkSupplements Pure Magnesium Citrate Powder (250 grams) - Magnesium is important for many reasons. One reason that is important to me is that it promotes brain cell genesis.
EXPLAINING HOW ACETYLCHOLINE AFFECTS THE GUT: 4/9/2018 update
If you are just beginning to take Choline and Acetyl L-Carnitine, be advised to start out with a small dose and work your way up. The book explains this very well in that your body being able to produce more AcetylCholine neurotransmitter will boost your brain; however, it will also boost all communication within the body, not just the brain. That means the gut-brain axis (talked about in the book) will also communicate more efficiently, which is a really good thing. Ever been constipated and don't really know why? Well, one reason I found out in how it affected me is that it can be exacerbated by deficient communication of the gut-brain axis because of a deficiency in the AcetylCholine neurotransmitter. Now reverse that when your body can all of a sudden produce the proper amounts of neurotransmitter AcetlCholine. I would start out with about 1/8 teaspoon Choline and 1/4 teaspoon Acetyl L-Carnitine (keeping a 1:2 ratio) and work your way up from there. Also, take the magnesium separately (i.e., different time of the day) if you are running into that issue as I have noticed combining the magnesium at the same time sometimes increases bowl transit time but separating them doesn't. Keep in mind that any undesirable effects an increase in the neurotransmitter will have is temporary while your body heals and realigns itself back to a normal functioning gut-brain axis. Another example, when I boosted my AcetlChoine neurotransmitter for the first time, my hands became a little more unsteady (he also talks about this in the book). One might think this then was a bad thing. Then, after about 4-7 days, my hands became more steady than they ever have been. Much more steady than before, and they have stayed steady ever since (now 4 years later). This is not a quick fix of your symptoms; this is information to heal your brain and nervous system to return it back to normal functioning. Just for reference, I am over 50 years of age. Just like he says in the book, if the temporary effects are too undesirable, then stop the supplements until the effects subside. Then start again at a lower dose. As your body heals, you will be able to increase the dose. It's difficult to explain it all here in a post. My suggestion is to buy the book as he explains all this and more.
Note: If anyone is interested in more supplements w/ information that I take, please post a comment and I will update the review.
[Update: 8/22/2014]
I have started following some of the advice this book gives and so far I am impressed. The part I really like is when he warns that when you start modifying your diet or supplements for brain health you might actually experience the opposite effect. This is exactly what happened to me. When I began I actually found it harder to think and concentrate. If I would have not had this warning I might have stopped. Other symptoms were mild gitters and mild diarrhea. All of that went away and now I'm thinking better than before. My hands are now more steady than before. And of course the diarrhea was temporary. He explains the connection between the brain and the GI tract as the gut-brain axis. He explains all the reasons why I had my experiences, so he gets six stars from me.
[Update: 10/29/2015]
I really cannot say enough about the direction this book has taken me in helping me with my brain health. You know, it's funny, we all can easily get how we have to eat protein to work out and gain muscle, but for some reason it is very difficult for us to understand what we have to do to maintain our brain health. Then we wonder why out parents, friends, and even ourselves are faced with mild cognitive impairment. I have done so much more to improve my brain health than even this book can describe; I would have to write a book myself, but... it all started with this book. I highly recommend you buy it, read it... no... study it, learn from it and keep learning from other sources as well. This book is a wonderful starting point. What a gift... it's the gift that keeps on giving.
REVIEW COMMENT POSTED BY Ann Larsen: [3/15/18 update]
She recommends a book "The End of Alzeheimer's" by Dale Bredesen. Please review her comments.
[+] HUMOR HEALS THE HEART:
Okay, you have read this review and found it helpful, but you're on the fence as to whether it was helpful enough to deserve a helpful vote. To click or not to click. Decisions, decisions. Well, I've come up with a little humorous spin about myself as it pertains to my devotion in creating helpful reviews. I've done this using the style of the comedic legend Rodney Dangerfield (1921-2004) and do this also in honor and memory of his great work. The plan is to get you chuckling as you click the helpful button. Let's see - here it goes:
"I tell ya, I just don't get no respect. I started writing reviews and getting helpful votes. Wow, this is cool, I said. I checked my profile and saw that my reviewer ranking was around #8000. So, I wrote more reviews. I was so excited when I checked my reviewer ranking to see it improve to around #7000, so I put even more time into writing reviews. I must be getting helpful votes, I thought, because my reviewer ranking then shot up to #5028. Alright, I said, I rolled up my sleeves, dropped everything and put ALL my time into my reviews. Then, I checked - my reviewer ranking said - #GETALIFE. No respect I tell ya. No respect at all."
GIVE Reviews - my standard for writing reviews.
[G]enuine - This is a review that is honest, trustworthy with no reason other than to help people in the Amazon family.
[I]nformational - This review needs to provide information related to this product in a concise matter.
[V]aluable - This review needs to provide value to the reader such that it helps him or her determine if this product is for them.
[E]nlightening - This review needs to go beyond product information such that the reader learns something they did not otherwise know.
Of the information, what which especially came as a surprise to me, was when I on side 357, under “Hormones and Brain Shape”, in the chapter 7, “The Hormone-Brain Connection”, read that: “When people undergo a sex change they take large amounts of hormones to develop the characteristics of the opposite sex”. And where this actually during a couple of months turns out into being a big work on changing the contain inside of the brain and at different places, when building up the new actual primary sex hormone, either testosterone or estrogen.
What which among other caught my interest in the book was the many places where we are reading about stress, with the primary stress hormone being cortisol, that is how stress works in bad ways. My reason to this is that since way back in 2003, I here in Ching Mai have been fighting with doctors about whether my seizures have been the result of epilepsy or stress. Back in the month of July 13 years ago I went to a psychiatric doctor here in Chiang Mai, and told him that I had stress as the result of my wife, whom I met 2 years before, fighting my driving motorcycle, which I had done during 30 years before I met her, and now being afraid that this stress might result in seizures.
The doctor didn’t find any connections in what I was talking about, and when then ¾ of a year later seizures then started to come, he then just told me that I was suffering from epilepsy, even though I only once had had a seizure, and that way back in 1975, 29 years ago. And the following doctors just repeating him, even though their epileptic drugs didn’t help. But here in this book I see written down much of what I during these years again and again to these doctors, have argued about stress, but in wain.
Here in this book we only look on when stress, as most often I believe, is bad, but in the book written by McGonigal, Kelly, PhD.: “The Upside of Stress”, stress actually is turned out into either being good or bad, as fifty-fifty, depending on which kind of stress and how we manage it.
In the book we of cause read about our blood pressure, which among other is depending on what we daily are eating, and of cause, we read that the correct blood pressure shall be 120/80. But here I probably for the first time ever hear/read, and as Kharrazian writes, that doctors normally newer tell, that the low pressure not must be less than 80, and if down on 70 or lower then something has to be done. Because with the low blood pressure it’s harder in forcing the blood up into the brain! And he advises what to do if either too high or too low.
Among other it’s also interesting in the book to read that as treatment known to increase the brain outcome (learning) include acupuncture, aromatherapy, biofeedback, chiropractic, hydrotherapy, massage, music, sound therapy, spinal manipulation, and yoga. Where normally we mostly are used in being told that reading, chess, mathematic, and so on are good for the brain training.
In the book we read about many herbs to use, for example, to increase the power in the brain, and as he writes, that drugs not yet have managed to get up on sides to the herbs when I come to working quality. So especially by the finish of many chapters we are getting much information about the actual herbs to use. I owe a couple of books about Herbs, and naturally have read about herbs in other books, but still in this book there was quite a bit of herbs which I never before had heard about.
It’s a fantastic book, by its much new contents, for example also about gluten sensitivity, which we now a days are getting more and more writings about, and of cause about inflammation, but among other for example that many men actually are having to low testosterone, and so on. So all together it’s a fantastic book.
Top reviews from other countries
Tried going to the doctors on several occasions only to be given an extremely basic memory test lasting no more than 1 minute then I was palmed off and sent on my way.
In desperation I kept searching for a root cause and the search brought me to this book.
I'm still currently reading but I can relate to so many things published in here and I have alot of avenues to try starting with my diet and nutrition, exactly what to eat and what to avoid.
Also detailed information about what's going on in the body and what your body needs to find balance and normality.
I'm positive there is a light at the end of the tunnel after reading this!
I got the Kindle version, but now want the paperback version to keep as a reference.
Edited to include a caution on taking supplements - tried Acetyl Tyrosine, Alpha L.Acid & L Carnitine & experienced worsening of under active thyroid (autoimmune hypothyroid) symptoms after single dose of each. Best to be cautious & vigilant for any detrimental effects! Was fine with tryptophan :-)










