Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum)
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- As recommended by Stephen Buhner
Product Description
Japanese Knotweed Tincture As recommended by Stephen Buhner Our very own herbal Extracts made with plants and herbs from Farmer friendly/sustainable and organic sources. We carry some standards and also hard to find tinctures. ****The products and the information provided about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site, product labeling or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before before taking any medication or supplements, especially if you are pregnant or if you have or suspect you might have a health problem.
Product details
- Is Discontinued By Manufacturer : No
- Date First Available : December 31, 2013
- Manufacturer : Montana Farmacy
- ASIN : B00HNFH5S0
- Best Sellers Rank: #255,195 in Health & Household (See Top 100 in Health & Household)
- #1,297 in Single Homeopathic Remedies
- Customer Reviews:
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|---|---|---|---|---|
| Customer Rating | 4.6 out of 5 stars (163) | 4.6 out of 5 stars (64) | 4.7 out of 5 stars (52) | 4.5 out of 5 stars (16) |
| Price | $12.50$12.50 | $12.50$12.50 | $44.00$44.00 | $45.00$45.00 |
| Sold By | MontanaFarmacy | MontanaFarmacy | MontanaFarmacy | MontanaFarmacy |
| Size | 1 Fl Oz (Pack of 1) | 1 Ounce (Pack of 1) | 4 Fl Oz (Pack of 1) | 4 Fl Oz (Pack of 1) |
Important information
Safety Information
****The products and the information provided about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. DO NOT USE PRODUCT IF YOU ARE CURRENTLY ON BLOOD THINNERS The information provided on this site, product labeling or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before before taking any medication or supplements, especially if you are pregnant or if you have or suspect you might have a health problem.
Ingredients
Organic Cane Alcohol, water and extractives of Japanese Knotweed. Please note we use Organic Cane Alcohol not sugar.
Directions
Suggested use is 30-40 drops 3 times a day Suggestion: put drops in about an ounce of warm water with honey or non acidic juice.
Legal Disclaimer
****The products and the information provided about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site, product labeling or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before before taking any medication or supplements, especially if you are pregnant or if you have or suspect you might have a health problem.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
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While limited trials have been performed in humans, researchers believe Japanese Knotweed’s benefits are attributed to the presence of resveratrol.
Over 67 polyphenols including quinones, stilbenes, flavonoids, coumarins and ligans have also been identified in Japanese Knotweed (2).
With the help of future studies, researchers will be able to better understand how these compounds contribute to this herb’s pharmacological effects.
Japanese knotweed improves inflammation and alleviates oxidative stress. Chronic inflammation is a contributing factor of age-related diseases and conditions such as diabetes, cardiovascular and autoimmune diseases (3). Inflammation and oxidative stress go hand-in-hand in that the inflammatory process induces oxidative stress, which in turn reduces the antioxidant defense system.
The aim of a 2010 study was to evaluate the effect of a Polygonum cuspidatum extract on oxidative and inflammatory stress in overall healthy participants.
Twenty adults were randomized to receive placebo or Polygonum cuspidatum extract containing 40 mg resveratrol daily for six weeks.
At the end of the study, supplementation with the extract resulted in a significant reduction in all the testing parameters for oxidative and inflammatory stress (4).
In another study, topical application of Polygonum cuspidatum extract inhibited the development of ear edema (swelling caused by the buildup of excess fluid in the body’s tissues) and inflammation in a mouse model (5).
Japanese knotweed promotes cardiovascular health. The results of a systematic review and meta-analysis of randomized, controlled, clinical trials revealed that when taken in high doses, resveratrol had a cardioprotective effect specifically in people with diabetes.
Dosages of ≥300 mg/day had a systolic blood pressure-lowering effect (6).
Japanese knotweed can be a potential treatment for rheumatoid arthritis. An arthritis- and inflammation-induced animal model used in a recent study revealed the ability of ethyl acetate extract of Polygonum cuspidatum to reduce inflammation and alleviate pain.
Researchers found the extract to be effective in providing pain relief in the animal hot plate test and tail-flick test at a dosage of 200 mg/kg. It did not, however, provide pain relief in the acetic acid-induced writhing test.
To evaluate the extract’s ability to reduce inflammation, researchers relied on a serotonin-induced paw edema model and Freund’s complete adjuvant (FCA)-induced adjuvant arthritis model.
It was found that the extract inhibited the swelling inflammatory response within 12 minutes after the serotonin injection, at both 100 and 200 mg/kg doses. In the FCA-induced adjuvant arthritis model, 100 mg/kg resulted in significantly suppressed joint swelling within five days, while 200 mg/kg of the extract showed the similar result within three days (7).
These results are encouraging especially for rheumatoid arthritis sufferers who, among other symptoms, experience joint pain and swelling.
Japanese knotweed may help speed the healing time of wounds. Polygonum cuspidatum extract has long been used in Traditional Chinese Medicine as a treatment to induce wound healing. In 2012, researchers set out to investigate its wound healing activity in a clinical setting using a rat study.
Results showed that in comparison to the control group, wound healing rates in the group treated with topical Polygonum cuspidatum extract were significantly higher at three, seven, 14 and 21 days.
In addition, microscopic studies revealed more well-organized bands of collagen, more fibroblasts and hair follicles and less inflammatory cells in the extract group (8).
Japanese Knotweed is also being studied for its possible role as a skin lightening agent.
Japanese knotweed helps to prevent the growth of human cancer cells. Results from in vitro and animal studies show resveratrol’s potential role in preventing and treating certain types of cancer (9). Researchers have found that resveratrol has an antitumor effect on neuroblastomas in mice; dose dependently inhibits the growth of estrogen receptor(ER)-positive MCF-7 cells (a breast cancer cell line used for clinical study); and induces human promyelocytic leukemia (HL-60) cell death.
In addition, resveratrol or a combination of resveratrol and quercetin are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation (10,11,12).
Japanese knotweed may help prevent flu viruses. In 2015, researchers tested the effects of over 300 traditional Chinese medicines on the replication of various influenza virus strains in a lung cell line. Impressively, of all the tested medicines, Polygonum cuspidatum and its active components, resveratrol and emodin, were found to effectively inhibit influenza virus replication, specifically the influenza A virus, including such strains as H1N1 (13).
Japanese knotweed may help treat allergies. Researchers have found that emodin, an anthraquinone compound present in Japanese knotweed, has the potential to prevent and treat allergic reactions. Using an in vivo passive anaphylaxis animal model and in vitro mouse bone marrow-derived mast cells, researchers noted that emodin has the ability to suppress activation of mast cells and thereby the anaphylactic reaction (14).
By Kim on January 21, 2021
Severall months later: I am reordering as I am now off of anticoagulants. It is the absolute best counter inflammation extract I have used. Japanese Knotweek tincture with it hugely high concentration of resveratrol keeps the inflammation of my joints down to the point where I can walk, turn pages in books, reach to my back to pull clothes on, etc. It works better than any other product I have tried and I don't have to take pain killers when I take the tincture--my dose is 10-15 drops tid.
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