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Jarrow Formulas 5-HTP 50mg, Brain and Memory Support, 90 Caps

3.8 out of 5 stars 281 customer reviews

About the product
  • 5-Hydroxytryptophan Capsules
  • May Be Useful In Promoting Mental Health (as a precursor to serotonin)
  • Melatonin Precursor: May Promote Sleep

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Product description

Style:50 mg  |  Size:90 Capsules

Product Profile

5-Hydroxytryptophan (5-HTP) is an amino acid naturally produced by the body from the essential amino acid L-tryptophan. 5-HTP is the immediate precursor to serotonin (5-hydroxytryptamine, 5-HT) and also a precursor to melatonin. In the brain, serotonin and melatonin help regulate sleep, mood, temperature, and appetite. As such, 5-HTP and L-tryptophan are often taken as supplements to support these roles.* Yet even though L-tryptophan can be transformed into 5-HTP in the body, the two should not be considered interchangeable for supplement use. The conversion of tryptophan to 5-HTP is the rate-limiting step in neurotransmitter production and, in addition, L-tryptophan is utilized for a variety of other purposes in the body leading to less serotonin support than may be assumed. In purified form, humans have been consuming 5-HTP for over forty years.


Distinguishing Features:

  • Sourced botanically from Griffonia simplicifolia
  • Serotonin & melatonin precursor
5-HTP vs. L-Tryptophan

The body uses L-tryptophan for other metabolic purposes besides serotonin and melatonin production. For example, L-tryptophan is incorporated into proteins and also acts as a precursor in niacin biosynthesis. L-tryptophan absorption in the intestines requires a shared amino acid transporter, meaning that competition with other amino acids from dietary sources can lead to poor L-tryptophan absorption. A similar specific, active transport mechanism is required for L-tryptophan entry into the brain. A number of other physiological and biochemical parameters, such as stress, insulin response, and vitamin B6 levels can conspire to prevent L-tryptophan from becoming serotonin.

In contrast, 5-HTP is not incorporated into proteins and cannot be used to produce niacin. 5-HTP does not require an intestinal transporter for absorption and is absorbed well even in the presence of other amino acids from food, with about 70 percent of that ingested ending up in the bloodstream. Also, since 5-HTP participates in fewer biosynthetic pathways it is inherently less susceptible to metabolic diversion. The only hindrance of importance for ingested 5-HTP is the activity of peripheral decarboxylase enzymes, which can convert 5-HTP to serotonin before crossing the blood-brain barrier. However, the results observed in 5-HTP research demonstrate that this is not a major concern.

Serotonin & The Second Brain

Some now use the phrase “our second brain” to refer to the impact our digestive tract can have on the entirety of the body. An example of this is the gut-brain axis, which involves extensive bidirectional signaling and feedback between gut and brain. For anyone who has attempted to diet in the past, this may already be understood experientially.

Serotonin plays a significant, yet not completely understood role in the human digestive tract and gut-brain axis. In fact, research demonstrates 5-HTP may even affect leptin, which helps to regulate energy intake and appetite.* Such a connection may help explain results in overweight individuals who were able to exert much better control over their diets when taking 5-HTP.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Product details

Style: 50 mg | Size: 90 Capsules
  • Product Dimensions: 6 x 5 x 4 inches ; 1 pounds
  • Shipping Weight: 0.6 ounces (View shipping rates and policies)
  • Domestic Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
  • International Shipping: This item can be shipped to select countries outside of the U.S. Learn More
  • ASIN: B0013OVSWG
  • UPC: 790011150442
  • Item model number: HTP50
  • Average Customer Review: 3.8 out of 5 stars 281 customer reviews
  • Amazon Best Sellers Rank: #12,052 in Health & Household (See Top 100 in Health & Household)
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Important information

Safety Warning
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications (especially SSRIs, MAOs, or sedatives), consult your health care practitioner before using this product.

Ingredients
5-HTP (5-Hydroxytryptophan), Cellulose, magnesium stearate (vegetable source) and silicon dioxide. Capsule consists of gelatin.

Directions
Take 1 capsule per day on an empty stomach or as directed by your qualified health careconsultant.

Legal Disclaimer
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. ** Always refer to the manufacturer's label on the product for description, recommended dose and precautions.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Directions Take 1 capsule per day on an empty stomach or as directed by your qualified health careconsultant. Follow usage directions on label. As a dietary supplement, take two (2) capsules once per day, preferably in the morning with the first meal along with 8 oz of water, or as directed by your healthcare professional. 1–6 capsules per day, in divided doses, before meals. This product is shipped with a desiccant. In order to maintain product freshness, customers are encouraged to leave the desiccant in the package until contents are consumed. Use under the guidance of a healthcare practitioner. Start with a low dose of one tablet (50 mg.) taken daily with a meal. Increase the dose slowly (every 3-5 days) up to a maximum of four tablets taken daily (200 mg.) Total daily intake should be divided into two or more doses, with no more than two tablets per dose. Take 1 capsule, with or without food, or as recommended by a nutritionally-informed physician.

Customer Questions & Answers

Customer Reviews

Top customer reviews

August 31, 2016
Style: 50 mg|Size: 90 Capsules|Verified Purchase
67 people found this helpful
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March 15, 2017
Style: 50 mg|Size: 90 Capsules|Verified Purchase
51 people found this helpful
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January 13, 2016
Style: 100 mg|Size: 60 Capsules|Verified Purchase
66 people found this helpful
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December 17, 2017
Style: 50 mg|Size: 90 Capsules|Verified Purchase
13 people found this helpful
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November 22, 2017
Style: 50 mg|Size: 90 Capsules|Verified Purchase
9 people found this helpful
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