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Life Extension Optimized Folate (l-methylfolate), 1000 Mcg, Vegetarian Tablets, 100-Count
| Price: | $14.63 ($0.15 / Count) $13.90 ($0.14 / Count) |
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| Brand | Life Extension |
| Item Form | Tablet |
| Diet Type | Vegetarian |
| Age Range (Description) | Adult |
| Specific Uses For Product | Nervous system |
About this item
- folate benefits cardiovascular health and nervous system function
- This bioactive folate is up to seven times more bioavailable than folic acid
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From the manufacturer
Life Extension Optimized Folate (l-methylfolate)
Our Optimized Folate formula promotes both cardiovascular and cognitive health with 1,000 mcg of folate in the form of L-Methylfolate.
- Supports both cardiovascular & cognitive health
- Helps maintain already-healthy homocysteine levels
- Delivers 1,000 mcg of the B vitamin folate
Folate Promotes Heart and Brain Health
Folic acid is a common B-vitamin supplement. Folate helps maintain healthy homocysteine levels already within the normal range. Homocysteine levels are an important biomarker for both cardiovascular and cognitive health—so be proactive. This formula delvers 1,000 mcg of L-Methylfolate. If you’re looking for 5-MTHF folate, try our High Potency Optimized Folate formula.
Product Description
Optimized Folate (L-Methylfolate), 1000 mcg, 100 vegetarian TABLETS. Optimized Folate (L-Methylfolate)1000 mcg, 100 vegetarian TABLETS. Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function. Those who take ordinary folic acid supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF). Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine). A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise blood serum folate levels compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 4 x 4 x 4 inches; 1.6 Ounces
- Item model number : 1312
- Date First Available : May 30, 2004
- Manufacturer : Life Extension
- ASIN : B002R3G8BS
- Best Sellers Rank: #21,600 in Health & Household (See Top 100 in Health & Household)
- Customer Reviews:
Product guides and documents
Compare with similar items
This item Life Extension Optimized Folate (l-methylfolate), 1000 Mcg, Vegetarian Tablets, 100-Count | Life Extension Optimized Folate (L-Methylfolate) – Supports Heart & Brain Health – Non-GMO, Gluten-Free, Vegetarian –1700 mcg DFE — 100 Vegetarian Tablets | Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical Grade Methylcobalamin (B12), Niacin, B1, B2 & B6. Works Synergistically for Max Results-3 Month Supply | L Methyl Folate 15mg Plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules) | Life Extension High Potency Optimized Folate, 8500 mcg - L-Methylfolate For Brain & Heart Health - Active Form of 5-MTHF Supplement - Gluten-Free, Non-GMO, Vegetarian - 30 Count | EZ Melts Folate as L-5-Methylfolate, 1,667 mcg DFE, Sublingual Vitamins, Vegan, Zero Sugar, Natural Orange Flavor, 60 Fast Dissolve Tablets | |
|---|---|---|---|---|---|---|
| Customer Rating | 4.7 out of 5 stars (2666) | 4.7 out of 5 stars (1845) | 4.6 out of 5 stars (4129) | 4.6 out of 5 stars (1054) | 4.6 out of 5 stars (368) | 4.6 out of 5 stars (815) |
| Price | $14.63$14.63 | $9.99$9.99 | $21.99$21.99 | $19.97$19.97 | $13.50$13.50 | $19.99$19.99 |
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| Sold By | PHARMCO | Amazon.com | One Elevated | Triquetra Health | Laxkubera | Solara, Inc. |
| Age Range Description | Adult | Adult | Adult | Adult | Adult | Adult |
| Brand Name | Life Extension | Life Extension | One Elevated | Triquetra Health | Life Extension | EZ Melts |
| Diet Type | Vegetarian | Vegetarian, Gluten Free | Vegan | — | Vegetarian | Vegan |
| Item Form | Tablet | Tablet | Capsule | Capsule | Tablet | Tablet |
| Serving Size Description | 1 ( tablets) | — | — | — | 1 ( tablets) | — |
| Specific Uses For Product | Nervous system | Heart health | Methyl folate with 5-MTHF. Good for people with MTHFR mutation | Heart Health,Brain,Nerve,Energy | Heart Health, Brain Health | Nervous system |
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Important information
Safety Information
Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. f you have a bad reaction to product discontinue use immediately. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Ingredients
Folate (1000 mcg). Folate (as 5-Methyltetrahydrofolic acid (5-MTHF), and calculated based upon the biologically Active 6S isomer). microcrystalline cellulose, vegetarian capsule, magnesium stearate, silicon dioxide.
Directions
Take one capsule daily with meals, or as recommended by a healthcare practitioner.
Legal Disclaimer
WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov/food.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonReviewed in the United States on January 19, 2019
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If I asked you which of these vitamins was found naturally in food, folate or folic acid, would you know the answer? If not, you’re in good company.
Many health professionals would even argue that folate and folic acid are essentially the same nutrient. While folic acid is often considered to be a supplemental form of folate, there is an important distinction between these two different compounds.
What’s the difference between folate and folic acid?
Folate is a general term for a group of water soluble b-vitamins, and is also known as B9. Folic acid refers to the oxidized synthetic compound used in dietary supplements and food fortification, whereas folate refers to the various tetrahydrofolate derivatives naturally found in food.
The form of folate that can enter the main folate metabolic cycle is tetrahydrofolate (THF). Unlike natural folates, which are metabolized to THF in the mucosa of the small intestine, folic acid undergoes initial reduction and methylation in the liver, where conversion to the THF form requires dihydrofolate reductase. The low activity of this enzyme in the human liver, combined with a high intake of folic acid, may result in unnatural levels of unmetabolized folic acid entering the systemic circulation.
Risks associated with excessive folic acid intake.
One of the major risks associated with excessive intake of folic acid is the development of cancer. In patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods, treatment with folic acid plus vitamin B12 was associated with increased cancer outcomes and all-cause mortality. In the United States, Canada, and Chile, the institution of a folic acid supplementation program was associated with an increased prevalence of colon cancer. A randomized control trial found that that daily supplementation with 1 mg of folic acid was associated with an increased risk of prostate cancer.
A high intake of folic acid might mask detection of vitamin B12 deficiency and lead to a deterioration of central nervous system function in the elderly.
L-methylfolate or 6(S)-5-methyltetrahydrofolate [6(S)-5-MTHF], is the primary biologically active diastereoisomer of folate and the primary form of folate in circulation. It is also the form which is transported across membranes into peripheral tissues, particularly across the blood brain barrier.
Folic acid, the synthetic form of folate, must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active. Genetic mutations of MTHFR result in a cell’s inability to convert folic acid to 6(S)-5-MTHF.
I got rid of Folic Acid on sale in Pharmacy, and I'm using L-Methylfolate. Be sure you buy L-Methylfolate, don't use Folic Acid, Plain Methylfolate (mixture 50% L-Methylfolate and 50% D-Methylfolate) and don't buy D-Methylfolate.
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