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Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To Hardcover – International Edition, September 10, 2019
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In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine’s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer.
For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease – it is inevitable.
But what if everything you think you know about ageing is wrong?
What if ageing is a disease? And that disease is curable.
In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world’s foremost authorities on genetics and ageing, argues just that. He has dedicated his life’s work to chasing more than a longer lifespan – he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick – a circuit designed to halt reproduction in order to repair damage to the genome –has enabled earth’s early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.
But genes aren’t our destiny; we have more control over them than we’ve been taught to believe. We can’t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes – like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy – can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like – and what will need to change – when we are all living well to 120 or more.
Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.
- Print length320 pages
- LanguageEnglish
- PublisherThorsons
- Publication dateSeptember 10, 2019
- Dimensions6.26 x 1.54 x 9.45 inches
- ISBN-100008353743
- ISBN-13978-0008353742
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Here’s the important point: there are plenty of stressors that will activate longevity genes without damaging the cell, including certain types of exercise, intermittent fasting, low-protein diets, and exposure to hot and cold temperatures (I discuss this in chapter 4). That’s called hormesis.Highlighted by 5,931 Kindle readers
They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.Highlighted by 4,845 Kindle readers
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The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body.Highlighted by 3,909 Kindle readers
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Product details
- Publisher : Thorsons (September 10, 2019)
- Language : English
- Hardcover : 320 pages
- ISBN-10 : 0008353743
- ISBN-13 : 978-0008353742
- Item Weight : 2.31 pounds
- Dimensions : 6.26 x 1.54 x 9.45 inches
- Best Sellers Rank: #1,048,871 in Books (See Top 100 in Books)
- #828 in Genetics (Books)
- #940 in Longevity
- #18,501 in Alternative Medicine (Books)
- Customer Reviews:
About the authors

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David A. Sinclair, Ph.D., A.O. is one of the world’s most famous and influential scientists, known for his work on controlling the aging process. He is a tenured Professor at Harvard Medical School and TIME magazine named him “one of the 100 most influential people in the world” (2014) and among the “Top 50 People in Healthcare” (2018). His newsletter is at www.lifespanbook.com and you can follow him on Twitter @davidasinclair or IG at davidsinclairphd. He has a top healthcare podcast series called Lifespan.
David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.
After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you’d most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world’s top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.
In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab’s discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.
Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing—and what that means for humanity going forward.
David is committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. For an updated list of activities, see https://genetics.med.harvard.edu/sinclair/.
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Customers find the book informative and well-researched on cutting-edge science. They appreciate its optimistic view of the future and eye-opening look at the work being done on curing the disease of aging. The pacing is described as eye-opening, solid, and well-structured. However, some readers find the text hard to follow and the metaphors poor. Opinions are mixed on value for money, with some finding it great and an excellent investment for their life, while others consider it overpriced and self-indulgent.
AI-generated from the text of customer reviews
Customers find the book provides well-researched and insightful information on aging well. They find it compelling and engaging, with thought-provoking questions that guide readers through the real challenges and progress on their path to aging well. The author does a great job of explaining complicated ideas in a simple way, and goes into detail on supplements and activities that can assist aging well.
"True insight into what ages us and doesn't. The fasting resetting your aging clock is true I think...." Read more
"...more on extending their lives--this book, written by the world-leading authority on aging and what it will take to extend our lives, gives concrete..." Read more
"...The first half of this book covers the history and amazing scientific discoveries, but unfortunately the second half oozes with virtue signaling as..." Read more
"This, and another book Outlive, give insight into how we should look at aging as a disease to be attacked. They both are insightful...." Read more
Customers find the book helpful for improving longevity. They say it explains the author's research and perspective on longevity. The book outlines how sirtuins are active, which allows us to live longer when they are activated. It also explains that aging is a disease and can be stopped and reversed. Readers appreciate the wisdom about cancer, heart disease, and dementia.
"True insight into what ages us and doesn't. The fasting resetting your aging clock is true I think...." Read more
"...It shows the already known value of fasting, in that the act of skipping meals causes the body to switch to a life-extending mode...." Read more
"...What that means is simply we live longer when these sirtuins are active. How can we do that? Read on...." Read more
"...It gave me key information about aging, longevity and the mix opinions that we have in our life now." Read more
Customers find the book offers an optimistic view of the future. They say it shows promise and offers hope for everyone. The author exudes optimism, which matches their natural tendency.
"...Sinclair exudes optimism, which matches my own natural tendency...." Read more
"Offers an optimistic view of what the future could hold for humans as they age. Learned a lot and was very interesting." Read more
"...A very thought-provoking book and one which offers a very optimistic view of the future, but one that I think ought to be expanded to integrate diet..." Read more
"...research on worms, rats, and other animals is fascinating and shows a ton of promise...." Read more
Customers find the book provides an eye-opening look at the work being done on curing aging. They appreciate the solid detail and clear explanations. The book is well-structured, easy to read, and well-documented.
"...The hard cover is gorgeous! With a grape colored cloth covering, I prefer it without the sleeve...." Read more
"...for those who aren’t looking to “live fast, die young, and leave a good-looking corpse” like a William Motley character...." Read more
"...A well documented book." Read more
"It was in excellent shape, even though I payed half price for it." Read more
Customers have different views on the book's readability. Some find it well-written and easy to follow, with a format that reads less like a scientific paper and more like a novel. They appreciate the many highlights and consider it legitimate. Others feel the text is hard to follow, with poor metaphors and technical language. The information can be weighty and difficult to understand, but some readers find it accessible.
"...It was scientifically convincing and legitimate-seeming all through. If you read one book this year--let it be this one...." Read more
"The book starts out written in doctorese and can be challenging to follow at times, but the content was so good, and so captivating, that I..." Read more
"...While the text is reasonably easy to follow, the information is still weighty and may be benefit from hearing a more high-level version first." Read more
"This is a well written and deeply researched book written by an expert in the field, with the help of a professional writer, that focuses on research..." Read more
Customers have different views on the book's value for money. Some find it valuable and a good investment, offering cutting-edge information about the subject matter. Others feel it's overpriced and self-centered.
"...at the elite level in which he does, you will still find great value in this book...." Read more
"...Prices start out high, which enables start-ups to raise capital. Then as volume goes up, unit costs are driven lower by competition...." Read more
"Bought it used ( thanks to who ever did the highlights!) at a big discount...." Read more
"...It is very expensive compared to regular niacin but may be worth it depending on your age...." Read more
Customers have mixed opinions about the humor. Some find it lighthearted and enjoyable to read, while others feel the tone is pretentious and self-congratulatory.
"...And the book is written in an extremely entertaining fashion...." Read more
"...much - seems a little snake oil salesman-y. He also has a very pretentious tone throughout...." Read more
"...Sinclair’s humor, on display in his Joe Rogan appearances, is also sprinkled in generously, such as wryly noting that 10,000-year intergalactic..." Read more
"...and still managed to make it lighthearted and enjoyable to read...." Read more
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- Reviewed in the United States on December 28, 2024True insight into what ages us and doesn't. The fasting resetting your aging clock is true I think. People always say I look at least 10 years younger than I am. I think maybe fasting from dinner to noon the next day must have been doing the trick for me without knowing it. I'll have to thank my evil grade school Math teacher who made me so upset, nervous and sick in class (cause I sucked at math and she would humiliate me) that for most of my life after her, I could not eat breakfast before I went to school or college and that continued into my work life though at that point I'd have coffee about 9 and eat about 10 so not quite until noon anymore.
- Reviewed in the United States on December 20, 2021Of the 34 books I have completed reading this year, this is the best.
Pay close attention to the subtitle. Though as we age, it's natural for humans to focus more and more on extending their lives--this book, written by the world-leading authority on aging and what it will take to extend our lives, gives concrete actionable guidance on what you personally can do to increase your life:
* It shows the already known value of fasting, in that the act of skipping meals causes the body to switch to a life-extending mode. That means you at the very least skip breakfast. Your goal is to go as long as possible every day without eating.
* It shows how the commercially available supplement NMN, a precursor to NAD, can have direct and noticeable effects on one's health and lifespan.
* It shows how lots of small effects, such as exposing yourself to extreme cold for brief periods of time also triggers your body's natural life-extending mechanisms. I am not attempting to reproduce a 310-page book. To fully understand, read this book or the many follow on talks given by the same author.
Sinclair begins this book by describing the "information theory of aging". Until his theory, the generally accepted idea has been that aging comes when the "digital" information that is held on DNA using the 4 base pairs becomes corrupted through information loss. Sinclair posits that aging is not a result of the corruption of DNA (which the body can fix) but the corruption of the companion to DNA that controls gene expression, the epigenome--which is separate set of chemicals and proteins that GOVERN how the DNA map is used to build proteins. Sinclair shows that it's possible to correct these epigenomic errors. The mechanism for doing this is quite interesting. It has been used to cause a damaged mouse optic nerve to re-grow. Absolutely fascinating and plausible in terms of the science involved.
So, I will give you what you came here to see. The author near the end gives his own personal regime for extending his life:
* 1,000 MG NMN supplement every morning
* 1,000 MG resveratrol every morning
* Daily dose Vitamin D, Vitamin K, aspirin
* Keep sugar, bread and pasta intake as low as possible.
* Allow yourself to be hungry for part of every day. Delay your first meal of the day as late as possible.
* Skip one meal a day or at least make it really small. (Try to go as long as possible between eating.)
* Lift weights
* Expose yourself briefly to extreme cold, because that also triggers your body's survival mechanisms.
This was a great and interesting read that I tore through. In no cases did the author make logical fallacies. It was scientifically convincing and legitimate-seeming all through.
If you read one book this year--let it be this one. It will show you how to live a longer life.
- Reviewed in the United States on October 28, 2019Lifespan: Why We Age – And Why We Don’t Have To
This is one of the most important books that I’ve read in the past decade. I’ve been excited about scientific progress against aging for the past 40 years, and have been taking supplements of various kinds since I was in my 20’s. David Sinclair’s book details most of the real progress in the field, with the best examples coming rather recently – in the past few years. Sinclair exudes optimism, which matches my own natural tendency.
As a narrative, the book succeeds in bringing the reader to an understanding of David’s initial motivation in his field, using the story of his grandmother Vera’s lifelong vitality giving way to decline and, ultimately, death. The reader also gets an historical retracing of the road to knowledge of telomeres, CRSPR, Sirtuins, and cell reprogramming. Did you know that there were sharks that have had life spans measured to have exceeded 500 years?
Twice, while in bed reading the book late at night, I bolted upright when a new fact was revealed. The first wake-up was an anecdote in the book about one of Sinclair’s researchers coming to him for help on an issue with the young man’s mother. Seems she had started having menstrual periods again after starting to take a supplement (NMN, I think) that many on David’s research team were taking themselves. Another shock was hearing of the reprogramming of optic tissue cells, using 3 of the 4 activators known to enable an adult cell to become a pluripotent stem cell. The 3 activators were CRSPR’d into the DNA of the receiving tissue, along with an activation mechanism that depends on receiving a certain antibiotic. So, dosage modulated regeneration of Optic nerve tissue was achieved in rats. That fact opens up the possibility of not only slowing or stopping aging, but actually reversing it.
The first half of this book covers the history and amazing scientific discoveries, but unfortunately the second half oozes with virtue signaling as it reveals David to be an altruistic collectivist with all manner of political prescriptions he thinks are needed to save humanity from itself – from gun control to climate activism. I suppose it is inevitable that the progressive bubble of an academic environment blinds its inhabitants by disallowing any political disagreement. However, it made me come to question Sinclair’s own scientific rigor. If he hasn’t read of the hiding of temperature data, and suspiciously always lower “adjustments” to past temperature records which is central to the global warming hoax, what alternative aging hypotheses might he be ignoring as well?
I dug into this a bit, after remembering that GlaxoSmithKline spent nearly a billion dollars back in 2008 for one of David’s startups working on Sirtuins (Sirtris). Back then, I was hoping that we’d see new anti-aging pharmaceuticals within a decade. Glaxo shut down the unit in 2013. That sounds ominous, right? But, comments on Glaxo’s page say that core researchers were offered positions in other parts of the company, and that Glaxo still thought the Sirtuin drug candidates were valuable.
In the book’s “Cast of Characters”, it is stated that Elizabeth Blackburn was “controversially dismissed” from Bush’s Council on Bioethics “allegedly for her advocacy of stem cell research and politics-free scientific inquiry.” What’s missing from this statement is that said advocacy was for “embryonic stem cell research”.
Bush’s constituency believed that this meant using human lives (albeit very young lives) for research, and this constituency did not want their tax money to pay for what they considered an immoral act. Again, the book seems to be using the material to make political jabs. Perhaps Dr Sinclair doesn’t realize this, perhaps he does.
Much is also made in the book’s second half about trying to guarantee that anti-aging therapies would be made available to all, regardless of cost. I would hope that the examples of pricing in the space, auto, and computer industries show how capitalist countries succeed in bringing costs down for everyone, without government mandates. Space Shuttles used to cost roughly $20,000/kg for orbital flights. SpaceX has brought that cost down to around $2,000/kg. It is still way too expensive for the average American tourist. However, cars were once only affordable to the wealthy. Henry Ford employed capital to force down prices, extending affordability to the middle class.
Prices start out high, which enables start-ups to raise capital. Then as volume goes up, unit costs are driven lower by competition. That’s how we got to 256GB USB sticks for $32. I once paid $10,000 for 0.004% of that much space. Drug prices would be driven down faster if the FDA only mandated safety testing, instead of both safety and efficacy. If drugs are guaranteed by the FDA to be safe, then we consumers should be allowed to try anything we want. Companies that want more market share would pay for efficacy trials, the results of which could be used in advertising. Drug development costs/prices might drop by 90% in that kind of market. Sure would cut the wait time for anti-aging therapies.
- Reviewed in the United States on December 14, 2024This, and another book Outlive, give insight into how we should look at aging as a disease to be attacked. They both are insightful. We have extended lifespan, but not so much heath span. As we all age, it is useful to get the insights from these two books.
- Reviewed in the United States on December 19, 2024The writing of this book gives hope to the possible future of aging with health, vitality, and living that healthy life to the fullest.
Top reviews from other countries
Judith SlaterReviewed in Canada on September 6, 20245.0 out of 5 stars Very interesting book...
Dr. David Sinclair is a total guru in his research. It's a good read, and simple enough to understand in the moment. I know the research has moved on since the book was written. I have read it twice to get a better understanding of what happens as we age. I've done a lot of what he suggests, and at 60, I feel absolutely fantastic! Great strength, agility, concentration, flexibiitly... knowing this lifestyle works according to the scientific research is a great motivator.
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JoelReviewed in Mexico on February 12, 20245.0 out of 5 stars Es pasta dura como la descripción
No lo he leído aún, pero el libro es muy bonito y es pasta dura.
Cliente AmazonReviewed in Brazil on March 21, 20235.0 out of 5 stars Excellent information and not difficult to read
Just informative reading
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José MacayaReviewed in Spain on January 6, 20225.0 out of 5 stars “EL” libro sobre el tema
Libro imprescindible para quién desea prolongar sus años de vida saludable. Me fue recomendado por un eminente oncólogo español, por lo que el contenido técnico viene respaldado por alguien que sabe mucho de esto. El libro consta de tres partes:
1. La primera parte explica una serie de conceptos técnicos que los legos tenemos dificultad en comprender en detalle, pero eso no impide entender de qué va la cosa. El capítulo 2 lo encontré especialmente arduo. Aviso esto para animar a quien se atasque en éste, a que siga adelante. No es necesario entender cada concepto.
2. La segunda parte es el meollo del libro. Explica no solo lo que hoy se sabe para mejorar la longevidad con salud, sino también todas las investigaciones que se están haciendo en este campo, que son muchísimas y promisorias. Esta parte no puede dejar de leerse.
3. La tercera es un repaso del mundo que se viene y de cómo va a estar impactado por el incremento de la longevidad y vida útil de las personas. El autor es una persona informada e inteligente, y tiene opiniones bien fundamentadas y válidas, pero sin duda donde ha volcado sus conocimientos especializados es en la segunda parte.
Mi amigo oncólogo me recomendó este libro sobre el envejecimiento. Le contesté que ya había leído otras cosas sobre el tema. A eso me insistió que este era “EL” libro sobre el tema. Tenía toda la razón. Supera en mucho cualquiera de mis otras lecturas sobre este tema. Además de ser útil para nuestras decisiones de vida, el libro deja unos conocimientos interesantes que permiten intuir en qué tipo de empresas se puede invertir para rentabilizar financieramente lo que se viene. Lo vamos a necesitar para vivir esos años extra…
MarkReviewed in the Netherlands on September 9, 20211.0 out of 5 stars Bad
Author talks about himself too much. Very little useful information.








