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Merial Frontline Plus Flea and Tick Control for 45 to 88-Pound Dogs, 6 Applicators

4.2 out of 5 stars 1,571 customer reviews
| 20 answered questions

List Price: $100.00
Price: $71.98 & FREE Shipping. Details
You Save: $28.02 (28%)
In Stock.
Ships from and sold by Amazon.com. Gift-wrap available.
  • Fast-acting, long-lasting flea and tick control for your pet
  • Kills all life stages of 4 major tick species
  • For dogs 45 to 88 pounds, Waterproof
  • Offers continuous protection for 30 days
  • Item is non-returnable; packaging may vary
10 new from $67.99 3 used from $62.95
Special Shipping Information: This product may not be available for 1 or 2 day shipping due to federal regulations that require it to ship via ground ship methods only. This product can only be shipped within the 48 contiguous states.


$71.98 & FREE Shipping. Details In Stock. Ships from and sold by Amazon.com. Gift-wrap available.

Frequently Bought Together

  • Merial Frontline Plus Flea and Tick Control for  45 to 88-Pound Dogs, 6 Applicators
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  • Merial Frontline Plus Flea and Tick Control for Cats and Kittens, 6 Doses
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  • MERIAL T-PET206 Frontline Plus Flea and Tick Control for Dogs and Puppies (6 Pack), 23 to 44 lb
Total price: $202.95
Buy the selected items together

Special Offers and Product Promotions

  • Buy Used and Save: Buy a Used "Merial Frontline Plus Flea and Tick Control for 4..." and save 37% off the $100.00 list price. Buy with confidence as the condition of this item and its timely delivery are guaranteed under the "Amazon A-to-z Guarantee". See all Used offers.

Product Description

Frontline Plus provides fast, effective and convenient treatment and control of fleas, ticks, and chewing lice. Research has shown that within 12 hours after application Frontline Plus killed 100% of fleas as well as breaking the flea life cycle to prevent future infestations.

Product Details

  • Product Dimensions: 5.8 x 1 x 4.5 inches ; 0.2 ounces
  • Shipping Weight: 0.8 ounces (View shipping rates and policies)
  • ASIN: B0002J1FOO
  • Item model number: P004FLTSP6-45-88
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (1,571 customer reviews)
  • Amazon Best Sellers Rank: #451 in Pet Supplies (See Top 100 in Pet Supplies)
  • Manufacturer’s warranty can be requested from customer service. Click here to make a request to customer service.

Important Information

Safety Warning
Keep out of reach of children

Customer Questions & Answers

Customer Reviews

Top Customer Reviews

By Peter Suslock TOP 500 REVIEWER on August 18, 2012
Verified Purchase
Allow me to caveat this review by saying out of 500 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bull dogs are in every sense of the word family. That said if you're reading these reviews your dog or dogs are your heart and using these products is a difficult choice to make, but for most of us it's one we have to make.

On that note, it's nice to be among my own kind of folks and it's my hope the following information has some value for you.

Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. It has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog.

It's a slippery slope, but in evaluating what's best for your dog and offers the most protection at the least risk Frontline and FrontLine Plus are hands down, without question your best bet.

Most tick and flea products contain Premethrin (or related compounds) as the active ingredient. Premethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Although thousands of dogs die every year from Premethrin and the FDA has mandated a minimal use of it not to exceed 750PPM companies continue to use it because it's cheap and effective.

What makes Premethrin so dangerous is that it can't distinguish between insects and mammals including human beings. It's been known to be lethal to cats since the 1970's. Even a slight transfer from dog to cat can result in seizures, brain damage and death.
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Verified Purchase
This is the real deal. I was leery after reading other posts from people saying their's was not legitimate. I think they older ones, from different sellers might be fake, but I think some of them are looking for a fake more than they are looking for evidence that it is not. This is the first time I bought these off Amazon and this is what I found (photos to show)
I made sure
it said "Ships from and sold by Amazon.com" ✓
Frontline inserts were in box ✓
the applicators had spaces between them ✓
the lot # on the applicator matched the lot number on the box ✓
the applicators each said Merial ✓
each applicator had instructions on how to open✓
The box I got did not look like the box on Amazon site, which worried me as it was the first thing I noticed. But I looked on Frontline's website and the 45 - 88 lb box they show looks like mine. The one on Amazon is an older model box, apparently.
Here is the real proof and the reason for my 5 stars.I have two labs. They are outdoor dogs(except for thunderstorms, snow, cold, etc) and they have never really had a problem with fleas before. When I take them to the groomers and ask if they had fleas, they usually say "one or two" but this year they were suffering. We noticed it and I immediately went to my trusty Amazon to see if it was sold, and I found all the concerns. I trust Amazon, so I ordered. As I am a prime member I knew I would get 2 days shipping, The next day I felt like a horrible dog owner. They were both whining and I could see fleas. They were miserable. The next day the package came in and I immediately did my check offs to prove it was legit. When it passed, we applied to our dogs. That night it was thundering so the babies came in. They sleep on their own indoor blankets.
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Our beagle began scratching and we noticed a flea on his belly area. We treat our lawn for insects including flea and ticks and have never needed to use any flea type product and he is 7 years old. We visited the local Pet Supermarket and they recommended the Frontline product. We purchased it followed the directions and the dog continued to scratch and chew his tail and the back area of his legs. We went back to the store to inform them the product that claims to immediately kill fleas and larva within hours is not working after two weeks. The clerk told us to apply it again so we did. Another 2 to 3 weeks later no change and we actually saw a flea on the belly. Once again the store clerk said to apply the remaining amount o the dog. After another 3 to 4 weeks our poor beagle still was biting and chewing. We visited the store once again and explained to the clerk we have now applied a three month amount of Frontline within a 9 weeks period with no results. This clerk (a different from past visits) actually would not recommend Frontline because he has heard the same complaint numerous times. He told us expressed he personally uses Advantage II and recommends the Advantage II to customers. I purchased the Advantage II (The Advantage II product is less expensive) applied to our dog and no kidding within 48 hours our dog stopped scratching and biting and his fur is now growing back.

During this entire time we went to the Frontline website. We thought it was odd that the website contact us does not include email capability! We wrote Frontline a letter and did receive a call approximately two (2) weeks later.
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