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The Messenger: Moderna, the Vaccine, and the Business Gamble That Changed the World Hardcover – July 26, 2022

4.2 4.2 out of 5 stars 56 ratings

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The inside story of an unprecedented feat of science and business.

At the start of 2020, Moderna was a biotech unicorn with dim prospects. Yes, there was the promise of its disruptive innovation that could transform medicine by using something called messenger RNA, one of the body's building blocks of life, to combat disease. But its stock was under water. There were reports of a toxic work culture. And despite ten years of work, the company was still years away from delivering its first product. Investors were getting antsy, or worse, skeptical.

Then the pandemic hit, and Moderna, at first reluctantly, became a central player in a global drama—a David to Big Pharma's Goliaths—turning its technology toward breaking the global grip of the terrible disease. By year's end, with the virus raging, Moderna delivered one of the world's first Covid-19 vaccines, with a stunningly high rate of protection. The achievement gave the world a way out of a crippling pandemic while validating Moderna's technology, transforming the company into a global industry power. Biotech, and the venture capital community that fuels it, will never be the same.

Wall Street Journal reporter Peter Loftus, veteran reporter covering the pharmaceutical and biotech industries and part of a Pulitzer Prize–finalist team, brings the inside story of Moderna, from its humble start at a casual lunch through its heady startup days, into the heart of the pandemic and beyond. With deep access to all of the major players, Loftus weaves a tale of science and business that brings to life Moderna's monumental feat of creating a vaccine that beat back a deadly virus and changed the business of medicine forever.

The Messenger spans a decade and is full of heroic efforts by ordinary people, lucky breaks, and life-and-death decisions. It's the story of a revolutionary idea, the evolution of a cutting-edge American industry, and one of the great achievements of this century.


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From the Publisher

reporter, journalist, journalism, vaccine, coronavirus, technology, mRNA, inside story, story

reporter, journalist, journalism, vaccine, coronavirus, technology, mRNA, inside story, story

reporter, journalist, journalism, vaccine, coronavirus, technology, mRNA, inside story, story

reporter, journalist, journalism, vaccine, coronavirus, technology, mRNA, inside story, story

reporter, journalist, journalism, vaccine, coronavirus, technology, mRNA, inside story, story

Editorial Reviews

Review

"This book offers a fascinating view inside the company behind the vaccine." — CHOICE, the publication of the American Library Association

"Mr. Loftus' book is an easy and great read for anyone interested in science and business." — Business Standard

"Wall Street Journal reporter Peter Loftus provides the inside track on the company in The Messenger, an engagingly pacy yet detailed narrative that traces the scientific origins of the Moderna story through the various dramas that led to the licensing of the vaccine in December 2020." — The Irish Times

"Offers readers an inside view of the company's ascent from secretive startup to one of the most valuable health care companies in the world." — Science magazine

"Based on nearly 300 interviews with more than 150 people, including Moderna employees, co-founders, members of the company's board and investors past and present, the book tells the story of the bet Moderna made on developing a vaccine for Covid-19." — Financial Times

"Wall Street Journal reporter Loftus charts in his captivating debut Moderna's spectacular rise from a small biotech company with "no products [and] no profits" in 2018 to a key player in the race for a Covid-19 vaccine." — Publisher's Weekly

"A satisfying look at how a smart business can both identify opportunity and do well by doing good." — Kirkus Reviews

Advance Praise for The Messenger:

"The Messenger delivers a riveting account of Moderna's unprecedented quest to develop a vaccine against Covid-19. With deep reporting and clear writing, Loftus compellingly chronicles the high-stakes drama behind one of the most important science-business stories of our time." — Ron Winslow, former Deputy Bureau Chief, Health and Science, and award-winning medical reporter, the Wall Street Journal

"Peter Loftus's new book is an in-depth look at how a controversial startup whose vaccine was one of the few miracles of the pandemic rose from nothing to a company that at its peak was valued at over $200 billion. The book is part business story, part science story, and entirely a story of people who wouldn't entertain the notion of failure." — Bethany McLean, contributing editor, Vanity Fair; columnist, Thomson Reuters; and coauthor, New York Times bestselling author, All the Devils Are Here

"The Messenger is a compelling, page-turning story of the development of the mRNA vaccine for Covid-19 by a collaboration between Moderna and scientists at the National Institutes of Health. Given the incredible importance of mRNA vaccines in combating both Covid-19 and other pathogens in the future, this well-written, accessible, and exciting narrative is a must-read." — Monica Gandhi, MD, MPH; Professor of Medicine and Associate Division Chief, HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco

About the Author

Peter Loftus writes about the pharmaceutical industry and health care for the Wall Street Journal. Based in Philadelphia, he covers large drugmakers, biotech firms, and the latest developments in drug research and innovation. He has followed Moderna and the wider chase for a Covid-19 vaccine from their start. He is part of a Journal reporting team that was a finalist for the Pulitzer Prize.

Follow Peter Loftus on Twitter @loftus.

Product details

  • Publisher ‏ : ‎ Harvard Business Review Press (July 26, 2022)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 320 pages
  • ISBN-10 ‏ : ‎ 1647823196
  • ISBN-13 ‏ : ‎ 978-1647823191
  • Item Weight ‏ : ‎ 1.2 pounds
  • Dimensions ‏ : ‎ 6.25 x 1.25 x 9.5 inches
  • Customer Reviews:
    4.2 4.2 out of 5 stars 56 ratings

About the author

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Peter Loftus
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PETER LOFTUS is a reporter for the Wall Street Journal, covering the drug and medical-device industries and other health care topics. He was part of a Journal team that won second place in the business category of the 2020 Association of Health Care Journalists’ awards for coverage of the race for a Covid-19 vaccine. In 2016 he was part of a Journal team that was a finalist for the Pulitzer Prize in explanatory reporting for a series of articles about rising prescription drug prices. Before joining the Journal in 2013, he was a reporter for Dow Jones Newswires, covering the pharmaceutical and technology industries. Before that, he worked for community newspapers in suburban Philadelphia. He graduated from the University of Notre Dame with a bachelor’s degree in English and history. He lives outside Philadelphia with his wife and three children.

Customer reviews

4.2 out of 5 stars
56 global ratings

Top reviews from the United States

Reviewed in the United States on March 10, 2023
Let me just state from the start: I am not in the health care industry or the pharmaceutical business. Thus, I thought this might be a tough read. But, I was so wrong! Loftus does a great job bringing a niche idea into layman’s language and created a readable, interesting, and thorough book. The book is peppered with little antidotes and well-written stories, that make this a great read. This is a fascinating book — such an interesting peek into how pharmaceutical start ups are build, survive and ultimately thrive.

I enjoyed the way Loftus let’s the reader get to know the players involved in Moderna with enough detail and history to become familiar with Moderna’s culture and big goals. I was rooting for them from the start. He takes a lengthy sidebar to explain the science behind the messenger RNA vaccine. It bogged me down for a bit, but ultimately it was extremely helpful in understanding the science and how bits and pieces from various patents and research partners came together.

On a broader note, this is an important piece of history to have summarized and documented. The quest for a vaccine was such an important moment in our country’s history and this book summarizes how Moderna contributed to the mission. Moderna’s solid basis in messenger RNA science put the company in the right place at the right time. Loftus does a great job unfolding the story of Moderna within the story of the quest for a vaccine. Honestly, although the pandemic was just a few years ago, I had forgotten (maybe purposely?) what a dark, scary time it was and how desperately we were all waiting for a vaccine. Loftus creates that feeling again as he describes all the events involved in tests and manufacturing the first vaccine.
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Reviewed in the United States on March 27, 2023
This book tells the story of Moderna, a company using an as yet unproven platform of messenger RNA technology, and how it stepped up to meet the threat of the SARS-CoV2 virus. Quite remarkable to see the development of this vaccine occur in less than a year. The book is well written and kept me engaged. It's worth a read
Reviewed in the United States on August 1, 2022
An amazing book that reveals the fast paced true story of both the science and business behind the Moderna mRNA vaccine. Mr. Loftus accurately communicates huge risk taking, constant challenges, and hard work between Moderna and the US government to develop and bring to market the vaccine. A seminal case study in entrepreneurialism and innovation that could only happen in America!
Reviewed in the United States on December 30, 2022
Messenger is a very readable story of how brilliant medical discoveries led to a small startup business and then in turn to the medical marvel that is the Moderna mRNA Covid Vaccine and the stock market darling that is today’s Moderna pharma business. If you enjoy compelling narratives of driven corporate leaders and venture capitalists, accompanied by insights into the entangled worlds of government oversight of medical research, government strategic response to medical crises, e.g., Covid, and pharmaceutical company competition - and greed - then this book makes a good read. My main gripes are as follows. There is not enough of the science underlying the mRNA vaccine. It is easy to lose ones bearings as to the timelines involved. And there are so many people involved that it would have been nice to have some photographs to help keep them straight.
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Reviewed in the United States on March 3, 2023
What a great look into the life cycle of a biotech startup -- from formation and funding through to all the steps necessary to get a new product to market to help address a global pandemic. Loftus did a great job of explaining the technical scientific data in a way a non-scientist can understand and making this non-fiction book read like a corporate/science-y drama.
Reviewed in the United States on January 1, 2023
With inside access to the major players, and the skillful eye of a journalist, Peter Loftus explores how Moderna’s all-in bet on its own technology vaulted the company into the lead in the race to develop a COVID-19 vaccine. Written in an accessible style that keeps you turning the pages to see what happens next. A must read for anyone interested in knowing how Moderna went from promising but far-from-a-sure-bet biotech to household name in just a couple of pandemic years.
Reviewed in the United States on November 19, 2022
I thought this was a great book! So interesting how a small company like Moderna exploded into a worldwide phenomenon. They changed the vaccines manufacturing process forever I think. And saved millions of lives. And made a fortune.
Reviewed in the United States on July 26, 2022
The book weaves multiple difficult concepts together into a easy to understand story. If you want to understand how mRNA works, read this book. If you want to understand the startup culture and financing, read this book. If you want to understand the role the US government played (and did not play) in the various vaccine deployments, read this book.
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Top reviews from other countries

Donald F. Gillis
1.0 out of 5 stars An inside,step by step monologue on Moderna.
Reviewed in Canada on August 15, 2022
The most disappointing book
I ever purchased. Not recommended.
It reads like Bancel’s diary.
Explicates the Pharma push
to get maximum return on
minimum investment,