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Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues Hardcover – April 8, 2014
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“In Missing Microbes, Martin Blaser sounds [an] alarm. He patiently and thoroughly builds a compelling case that the threat of antibiotic overuse goes far beyond resistant infections.”―Nature
Renowned microbiologist Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the equilibrium and health of our bodies. Now this invisible Eden is under assault from our overreliance on medical advances including antibiotics and caesarian sections, threatening the extinction of our irreplaceable microbes and leading to severe health consequences.
Taking us into the lab to recount his groundbreaking studies, Blaser not only provides elegant support for his theory, he guides us to what we can do to avoid even more catastrophic health problems in the future.
“Missing Microbes is science writing at its very best―crisply argued and beautifully written, with stunning insights about the human microbiome and workable solutions to an urgent global crisis.”―David M. Oshinsky, author of the Pulitzer Prize-winning Polio: An American Story
- Print length288 pages
- LanguageEnglish
- PublisherHenry Holt and Co.
- Publication dateApril 8, 2014
- Dimensions6.3 x 1.05 x 9.39 inches
- ISBN-100805098100
- ISBN-13978-0805098105
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“The weight of evidence behind Dr. Blaser's cautions about antibiotics is overwhelming.” ―The New York Times
“Unlike some books on medicine and microbes, Dr. Blaser's doesn't stir up fears of exotic diseases or pandemic 'superbugs' resistant to all known drugs. He focuses on a simpler but more profound concern: the damage that modern life inflicts on the vast number of microbes that all of us, even healthy people, carry inside us at all times.” ―The Wall Street Journal
“Missing Microbes presents a surprisingly clear perspective on a complex problem.” ―Philadelphia Inquirer
“In Missing Microbes, Martin Blaser sounds [an] alarm. He patiently and thoroughly builds a compelling case that the threat of antibiotic overuse goes far beyond resistant infections.” ―Nature
“Readable and challenging, Missing Microbes provides a stimulus with which to probe existing dogma.” ―Science
“Blaser presents a sensible plan for reclaiming our microbial balance and avoiding calamity both as a society...and on an individual level.” ―Discover
“Missing Microbes blazes a new trail.” ―The Huffington Post
“An engrossing examination of the relatively unheralded yet dominant form of life on Earth.” ―Publishers Weekly (starred review)
“Blaser's Missing Microbes is a masterful work of preventative health and superb science writing.” ―Booklist (starred review)
“Credit Blaser for displaying the wonders and importance of a vast underworld we are jeopardizing but cannot live without.” ―Kirkus
“Missing Microbes adds a new frontier towards understanding vastly underappreciated key contributions of the human microbiome to health and human disease. As a world leader in defining the microbiome, Dr. Blaser explains how disturbing its natural balance is affecting common conditions such as obesity and diabetes, long thought of as primarily nutrition and lifestyle related problems. Blaser's carefully and convincingly written book outlines new dimensions that need to be considered in fighting a number of common diseases and in promoting health and well-being.” ―Richard Deckelbaum, Director, Institute of Human Nutrition, Columbia University
“In a world that turns to antibiotics for every infection of the ear, sinuses, or skin, Dr. Blaser makes even the most nervous parent think twice about giving her child these ubiquitous drugs. Dr. Blaser contends that the excessive use of antibiotics--especially in children--is at the root of our most serious emerging modern maladies, from asthma and food allergies to obesity and certain cancers. He walks us through the science behind his theories and examines the duality of microbes, both as essential agents of good health and perpetrators of sickness. At a time when the Centers for Disease Control and Prevention is campaigning for more judicious use of antibiotics, Dr. Blaser delivers a thoughtful, well-written and compelling case for why doctors need to be more cautious about prescribing these medications and why consumers should consider alternatives before taking them.” ―Nirav R. Shah, MD, MPH, Commissioner of Health, New York
“Dr. Blaser's credibility as a world class scientist and physician makes this exploration of our body's microbial world particularly provocative. Missing Microbes will make you rethink some fundamental ideas about infection. Blaser's gift is to write clearly and to take the reader on a fascinating journey through the paradoxes and insights about the teeming world within us.” ―Abraham Verghese MD, author of Cutting for Stone
“I have often wondered why kids today seem to have such a high incidence of asthma, ear infections, allergies, reflux esophagitis and so many other conditions that I rarely saw growing up. This mystery has been solved by the pioneering work of Dr. Marty Blaser and is communicated brilliantly in Missing Microbes. I cannot emphasize enough the importance of this book to your own health, the health of your children and grandchildren and to the health of our country. Missing Microbes is truly a must read.” ―Arthur Agatston, author of The South Beach Diet
“We live today in a world of modern plagues, defined by the alarming rise of asthma, diabetes, obesity, food allergies, and metabolic disorders. This is no accident, argues Dr. Blaser, the renowned medical researcher: the common link being the destruction of vital bacteria through the overuse of broad-spectrum antibiotics. Missing Microbes is science writing at its very best--crisply argued and beautifully written, with stunning insights about the human microbiome and workable solutions to an urgent global crisis.” ―David M. Oshinsky, author of the Pulitzer Prize-winning Polio: An American Story
“Why is it that you are fat, your son has asthma, and your 13-year-old daughter is six feet tall? Dr. Blaser says your bodies are missing vital, beneficial bacteria and I guarantee that after reading this book you will agree. Take a pass on the antibiotics and read Missing Microbes.” ―Laurie Garrett, Pulitzer Prize winning writer and Senior Fellow for Global Health at the Council on Foreign Relations
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Product details
- Publisher : Henry Holt and Co.; First edition (April 8, 2014)
- Language : English
- Hardcover : 288 pages
- ISBN-10 : 0805098100
- ISBN-13 : 978-0805098105
- Item Weight : 1.05 pounds
- Dimensions : 6.3 x 1.05 x 9.39 inches
- Best Sellers Rank: #439,980 in Books (See Top 100 in Books)
- #297 in Microbiology (Books)
- #360 in Sociological Study of Medicine
- #839 in Anatomy (Books)
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When Rachel Carson wrote Silent Spring in 1962, she meticulously documented that widespread and mounting pesticide use was impacting far more than the intended insect targets. She pointed out what many people could already sense, that bird and other wildlife populations were dropping precipitously in areas heavily sprayed with pesticides and that human health in and around those areas was probably being degraded. Her book galvanized citizenry and policy makers to consider the full impact of powerful chemicals on what we would today call the “ecosystem.”
Fifty plus years later, Dr. Martin Blaser, former chair of medicine at NYU and a past president of the Infectious Disease Society of America, has written a book which painstakingly lays out how antibiotics impact both the pathogenic as well as symbiotic bacteria which line our intestines. He begins his book with a rumination on the “modern plagues” of today which typically involve our metabolic or immune systems: obesity, childhood diabetes, asthma, food allergies, esophageal reflux and cancer, celiac disease, and IBD among others. Blaser wonders if there is some general change in our lives that could be fueling their collective rapid growth. His prime suspect(s) are the wonder drugs of the twentieth century: antibiotics. While these drugs have saved millions of lives (including Blaser’s own) they also destroy, and are likely cumulatively destroying, bacteria that are crucial for properly regulating metabolic and inflammatory processes within our bodies.
Blaser weaves basic scientific explication together with personal experiences from the practice of medicine and his work with the Centers for Disease Control. He compares analysis of massive US and Danish health databases with the results of mouse experiments in his own lab at NYU. He recounts episodes from his own family’s health history. From each of these varied perspectives, a remarkably consistent message emerges: repeated courses of antibiotics, especially those taken in early childhood, leave us increasingly susceptible to each of the modern plagues.
Fifty years ago Silent Spring helped create awareness that ecological balance was crucial to sustaining the habitats that support our lives. It is my fervent hope that Missing Microbes creates a similar awareness: that balance and diversity among the microbes that form our microbiome is crucial if we wish to have functional metabolic and immune systems to support our lives.
There is now new research in the world of gut bacteria which brings hope to us all. My message to anyone that reads this book. Take a leap and try probiotics for your self. I suffered from brain fog, sleep apnea, anxiety, trouble loosing weight, skin acne I can go on and on. But once I changed my diet, and started taking Pre and Probiotics it literally saved my life. I even found alternate ways to inject them and it was remarkable how I feel now. This field is so promising and god bless the men and women who dedicated their lives to bring all this information to light.
To accurately rate this book - I give this a 4.5 out of 10. The information presents in Blaser's book is founded upon medical research and research conducted by himself and other notable colleagues. He does have a tendency to repeat certain topics, however it is to ingrain into the reader how important these concepts are and how our "missing microbes" affect our current chronic disease climate.
I say that because it would be easy to decide that you never want to be near an antibiotic again after reading some sections of this book. Dr. Blaser does an excellent job of balancing the potential risks with the known benefits, but it still leaves the reader recounting every course of antibiotics ever taken and holding a quiet vigil for all of the valuable microbes likely lost.
While the information is valuable, the writing style was a bit uneven. The sections that tell the story of an individual are engaging. However, some of the sections that explain pure science can feel a bit too simplistic. This is obviously an attempt to make the book accessible for all kinds of readers, which it is, but it can be dry at times. Be prepared to push through those pages, because the book is definitely worth finishing.
If you'd like a better idea of what this is all about, check out Dr. Blaser's interview with Terry Gross in April. It's a great overview, and you'll probably be clicking Buy before they're done talking.
Top reviews from other countries
5 stelle all’autore e al libro
Libro affascinante, ricco di aneddoti e storie cliniche che rendono la lettura coinvolgente e appassionante.
L’autore, stimato ricercatore e direttore del Human Microbiome Project alla NYU, ha una ottima capacità di raccontare, informare, coinvolgere il lettore in osservazioni, scoperte e congetture che cambiano il nostro modo di vedere il mondo vivente.
Verso la conclusione diviene visionario e un po’ apocalittico; ma ciò è parte dello scopo del libro.
3 stelle alla versione Kindle (versione 5.1 per iPad)
Il 20% del libro (equivalente a circa 58 pagine a stampa) è costituito da note.
Note che non sono, come spesso capita, noiosi riferimenti accademici, ma sono ricche integrazioni al testo principale.
Nell'edizione Kindle le note non sono visibili durante la lettura del testo e, una volta scoperta la loro esistenza alla fine del documento, non è possibile risalire al testo al quale si riferiscono. In tal modo si perde quasi totalmente l’utilità delle note.
Chemistry, biology, evolution, and the practical health sciences of people and microbes.
This books offers some great insights on the importance of our microbiome and the incredible biodiversity of microbes in our body, emohasizing H pylori and the correlation and potential causalities resulting from the war on this age old microbe.
Found the chapter on child birth fascinating.
Great read!
Damit kommen als weiterer, nicht genannter Faktor Herbizide ins Spiel. Einige dieser Herbizide, allen voran RoundUp (Glyphosat), die in (mindestens) zehntausenden Tonnen weltweiit jährlich auf die Felder gespritzt werden, haben eine relativ potente Wirkung gegen Mikroorganismen und Glyphosate wurde ja sogar als Antibiotikum patentiert. Eine enonorme Schädigung nicht nur der Bodenbakterien sondern auch krebserzeugende Wirkungen auf verschiedene tierische und menschlichen Gewebe wurden in mehreren Studien der letzten Jahre publiziert.
Alle die in "Missing Microbes" beschriebenen gesundheitlichen Auswirkungen einer veränderten Darmflora wurden und werden auch für Glyphosate beschrieben bzw. dringend verdächtigt. Insofern kann das Buch nicht nur im Kontext der klassischen Antibiotika (therapeutische Anwendung bei Infektionen sowie Tiermast!) sondern genau von Roundup (Glyphosate), Glufosinate und einger anderer Herbizide/Pestizide gesehen werden. Trotz dieser bedauerlichen Lücke hat das Buch zweifellos fünf Sterne verdient!
Christian Lee, Schweiz








